BACKGROUND: Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional susceptibility loci shared by psoriasis and SLE in the Chinese Han population. METHODS: In total, 20 single nucleotide polymorphisms (SNPs) in 17 previously reported psoriasis susceptibility loci and 34 SNPs from 24 previously reported SLE susceptibility loci were investigated in our initial psoriasis and SLE GWAS dataset. Among these SNPs, we selected two SNPs (rs8016947 and rs4649203) with association values of p<5×10(-2) for both diseases in the GWAS data for further investigation in psoriasis (7260 cases and 9842 controls) and SLE (2207 cases and 9842 controls) using a Sequenom MassARRAY system. RESULTS: We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)). CONCLUSIONS: These results showed that two common susceptibility loci (NFKBIA and IL28RA) are shared by psoriasis and SLE in the Chinese Han population.
BACKGROUND: Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional susceptibility loci shared by psoriasis and SLE in the Chinese Han population. METHODS: In total, 20 single nucleotide polymorphisms (SNPs) in 17 previously reported psoriasis susceptibility loci and 34 SNPs from 24 previously reported SLE susceptibility loci were investigated in our initial psoriasis and SLE GWAS dataset. Among these SNPs, we selected two SNPs (rs8016947 and rs4649203) with association values of p<5×10(-2) for both diseases in the GWAS data for further investigation in psoriasis (7260 cases and 9842 controls) and SLE (2207 cases and 9842 controls) using a Sequenom MassARRAY system. RESULTS: We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)). CONCLUSIONS: These results showed that two common susceptibility loci (NFKBIA and IL28RA) are shared by psoriasis and SLE in the Chinese Han population.
Authors: David L Morris; Yujun Sheng; Yan Zhang; Timothy J Vyse; Yong-Fei Wang; Zhengwei Zhu; Philip Tombleson; Lingyan Chen; Deborah S Cunninghame Graham; James Bentham; Amy L Roberts; Ruoyan Chen; Xianbo Zuo; Tingyou Wang; Leilei Wen; Chao Yang; Lu Liu; Lulu Yang; Feng Li; Yuanbo Huang; Xianyong Yin; Sen Yang; Lars Rönnblom; Barbara G Fürnrohr; Reinhard E Voll; Georg Schett; Nathalie Costedoat-Chalumeau; Patrick M Gaffney; Yu Lung Lau; Xuejun Zhang; Wanling Yang; Yong Cui Journal: Nat Genet Date: 2016-07-11 Impact factor: 38.330
Authors: Lam C Tsoi; Sarah L Spain; Eva Ellinghaus; Philip E Stuart; Francesca Capon; Jo Knight; Trilokraj Tejasvi; Hyun M Kang; Michael H Allen; Sylviane Lambert; Stefan W Stoll; Stephan Weidinger; Johann E Gudjonsson; Sulev Koks; Külli Kingo; Tonu Esko; Sayantan Das; Andres Metspalu; Michael Weichenthal; Charlotta Enerback; Gerald G Krueger; John J Voorhees; Vinod Chandran; Cheryl F Rosen; Proton Rahman; Dafna D Gladman; Andre Reis; Rajan P Nair; Andre Franke; Jonathan N W N Barker; Goncalo R Abecasis; Richard C Trembath; James T Elder Journal: Nat Commun Date: 2015-05-05 Impact factor: 14.919