| Literature DB >> 28991256 |
Zhiqiang Li1,2,3,4, Jianhua Chen2,5, Hao Yu6,7,8, Lin He2,4, Yifeng Xu5, Dai Zhang6,7,9, Qizhong Yi10, Changgui Li11, Xingwang Li2, Jiawei Shen2, Zhijian Song2, Weidong Ji4,12, Meng Wang2, Juan Zhou2, Boyu Chen2, Yahui Liu2, Jiqiang Wang2, Peng Wang13, Ping Yang13, Qingzhong Wang2, Guoyin Feng5, Benxiu Liu14, Wensheng Sun14, Baojie Li2, Guang He2, Weidong Li2, Chunling Wan2, Qi Xu15, Wenjin Li2, Zujia Wen2, Ke Liu2, Fang Huang2, Jue Ji2, Stephan Ripke16,17,18, Weihua Yue6,7, Patrick F Sullivan19,20, Michael C O'Donovan21, Yongyong Shi1,2,3,4,10,12.
Abstract
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.Entities:
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Year: 2017 PMID： 28991256 DOI： 10.1038/ng.3973
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330