Literature DB >> 27383910

Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Kelsey R Beavers1, Thomas A Werfel2, Tianwei Shen2, Taylor E Kavanaugh2, Kameron V Kilchrist2, Jeremy W Mares3, Joshua S Fain3, Carrie B Wiese4, Kasey C Vickers5, Sharon M Weiss3, Craig L Duvall6.   

Abstract

Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  PNA; anti-miRNA; nanocomposite; peptide nucleic acids; porous silicon

Mesh：

Substances：

Year:  2016        PMID： 27383910      PMCID： PMC5152671          DOI： 10.1002/adma.201601646

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  30 in total

Review 1.  MicroRNA gets down to business.

Authors:  George S Mack
Journal:  Nat Biotechnol       Date:  2007-06       Impact factor: 54.908

2.  The association of silicon microparticles with endothelial cells in drug delivery to the vasculature.

Authors:  Rita E Serda; Jianhua Gu; Rohan C Bhavane; XueWu Liu; Ciro Chiappini; Paolo Decuzzi; Mauro Ferrari
Journal:  Biomaterials       Date:  2009-02-12       Impact factor: 12.479

3.  A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides.

Authors:  Su Young Oh; YeongSoon Ju; Heekyung Park
Journal:  Mol Cells       Date:  2009-09-30       Impact factor: 5.034

4.  The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH.

Authors:  Rikke V Benjaminsen; Maria A Mattebjerg; Jonas R Henriksen; S Moein Moghimi; Thomas L Andresen
Journal:  Mol Ther       Date:  2012-10-02       Impact factor: 11.454

5.  Enhanced Performance of Plasmid DNA Polyplexes Stabilized by a Combination of Core Hydrophobicity and Surface PEGylation.

Authors:  Elizabeth J Adolph; Christopher E Nelson; Thomas A Werfel; Ruijing Guo; Jeffrey M Davidson; Scott A Guelcher; Craig L Duvall
Journal:  J Mater Chem B       Date:  2014-12-14       Impact factor: 6.331

Review 6.  The Whereabouts of microRNA Actions: Cytoplasm and Beyond.

Authors:  Anthony K L Leung
Journal:  Trends Cell Biol       Date:  2015-10       Impact factor: 20.808

7.  PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells.

Authors:  Peter N Brown; Hang Yin
Journal:  Chem Commun (Camb)       Date:  2012-10-31       Impact factor: 6.222

8.  Principles of nanoparticle design for overcoming biological barriers to drug delivery.

Authors:  Elvin Blanco; Haifa Shen; Mauro Ferrari
Journal:  Nat Biotechnol       Date:  2015-09       Impact factor: 54.908

Review 9.  Porous silicon advances in drug delivery and immunotherapy.

Authors:  David J Savage; Xuewu Liu; Steven A Curley; Mauro Ferrari; Rita E Serda
Journal:  Curr Opin Pharmacol       Date:  2013-07-08       Impact factor: 5.547

10.  Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix.

Authors:  Hongbo Zhang; Dongfei Liu; Mohammad-Ali Shahbazi; Ermei Mäkilä; Bárbara Herranz-Blanco; Jarno Salonen; Jouni Hirvonen; Hélder A Santos
Journal:  Adv Mater       Date:  2014-04-16       Impact factor: 30.849
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  17 in total

1.  Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability.

Authors:  Kameron V Kilchrist; Somtochukwu C Dimobi; Meredith A Jackson; Brian C Evans; Thomas A Werfel; Eric A Dailing; Sean K Bedingfield; Isom B Kelly; Craig L Duvall
Journal:  ACS Nano       Date:  2019-01-18       Impact factor: 15.881

2.  Delivery of Peptide Nucleic Acids Using an Argininocalix[4]arene as Vector.

Authors:  Alessia Finotti; Jessica Gasparello; Alessandro Casnati; Roberto Corradini; Roberto Gambari; Francesco Sansone
Journal:  Methods Mol Biol       Date:  2021

3.  Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging.

Authors:  Makan Khoshnejad; Colin F Greineder; Katherine W Pulsipher; Carlos H Villa; Burcin Altun; Daniel C Pan; Andrew Tsourkas; Ivan J Dmochowski; Vladimir R Muzykantov
Journal:  Bioconjug Chem       Date:  2018-02-19       Impact factor: 4.774

4.  The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome.

Authors:  Jessalyn J Baljon; Aamina Dandy; Lihong Wang-Bishop; Mohamed Wehbe; Max E Jacobson; John T Wilson
Journal:  Biomater Sci       Date:  2019-04-23       Impact factor: 6.843

Review 5.  Nanoscale delivery systems for microRNAs in cancer therapy.

Authors:  Sanda Boca; Diana Gulei; Alina-Andreea Zimta; Anca Onaciu; Lorand Magdo; Adrian Bogdan Tigu; Calin Ionescu; Alexandru Irimie; Rares Buiga; Ioana Berindan-Neagoe
Journal:  Cell Mol Life Sci       Date:  2019-10-21       Impact factor: 9.261

Review 6.  Applications of PNA-laden nanoparticles for hematological disorders.

Authors:  Shipra Malik; Stanley Oyaghire; Raman Bahal
Journal:  Cell Mol Life Sci       Date:  2018-11-29       Impact factor: 9.261

7.  Porous Silicon Nanoparticles Embedded in Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth.

Authors:  Jonathan M Zuidema; Courtney M Dumont; Joanna Wang; Wyndham M Batchelor; Yi-Sheng Lu; Jinyoung Kang; Alessandro Bertucci; Noel M Ziebarth; Lonnie D Shea; Michael J Sailor
Journal:  Adv Funct Mater       Date:  2020-05-11       Impact factor: 18.808

Review 8.  An Analysis of Mechanisms for Cellular Uptake of miRNAs to Enhance Drug Delivery and Efficacy in Cancer Chemoresistance.

Authors:  Justine M Grixti; Duncan Ayers; Philip J R Day
Journal:  Noncoding RNA       Date:  2021-04-16

9.  A Dominant Negative Antisense Approach Targeting β-Catenin.

Authors:  Matthias Vonbrüll; Elisabeth Riegel; Christian Halter; Michaela Aigner; Holger Bock; Birgit Werner; Thomas Lindhorst; Thomas Czerny
Journal:  Mol Biotechnol       Date:  2018-05       Impact factor: 2.695

Review 10.  Applications of RNA Indexes for Precision Oncology in Breast Cancer.

Authors:  Liming Ma; Zirui Liang; Hui Zhou; Lianghu Qu
Journal:  Genomics Proteomics Bioinformatics       Date:  2018-05-09       Impact factor: 7.691
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