Literature DB >> 23111503

PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells.

Peter N Brown1, Hang Yin.   

Abstract

Peptide nucleic acid (PNA) inhibitors of miR-221-3p (CU-PNA-221) and miR-466l-3p (CU-PNA-466) demonstrated changes in inflammatory responses. Suppression of inflammatory signalling was unexpected and further investigation led to the identification of calmodulin as a novel target of miRNA-466l-3p. These studies demonstrate that exogenous agents may suppress neuroinflammation mediated by microglial cells.

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Year:  2012        PMID： 23111503      PMCID： PMC3593954          DOI： 10.1039/c2cc36540e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

Review 1.  MicroRNAs: small RNAs with a big role in gene regulation.

Authors:  Lin He; Gregory J Hannon
Journal:  Nat Rev Genet       Date:  2004-07       Impact factor: 53.242

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Authors:  Benjamin P Lewis; Christopher B Burge; David P Bartel
Journal:  Cell       Date:  2005-01-14       Impact factor: 41.582

3.  Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.

Authors:  Martin Fenger-Grøn; Christy Fillman; Bodil Norrild; Jens Lykke-Andersen
Journal:  Mol Cell       Date:  2005-12-22       Impact factor: 17.970

4.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.

Authors:  Liya Qin; Xuefei Wu; Michelle L Block; Yuxin Liu; George R Breese; Jau-Shyong Hong; Darin J Knapp; Fulton T Crews
Journal:  Glia       Date:  2007-04-01       Impact factor: 7.452

5.  Prediction of both conserved and nonconserved microRNA targets in animals.

Authors:  Xiaowei Wang; Issam M El Naqa
Journal:  Bioinformatics       Date:  2007-11-29       Impact factor: 6.937

6.  A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides.

Authors:  Su Young Oh; YeongSoon Ju; Heekyung Park
Journal:  Mol Cells       Date:  2009-09-30       Impact factor: 5.034

Review 7.  MicroRNAs: the fine-tuners of Toll-like receptor signalling.

Authors:  Luke A O'Neill; Frederick J Sheedy; Claire E McCoy
Journal:  Nat Rev Immunol       Date:  2011-02-18       Impact factor: 53.106

8.  Peptide nucleic acid films and capsules: assembly and enzymatic degradation.

Authors:  Alisa L Becker; Angus P R Johnston; Frank Caruso
Journal:  Macromol Biosci       Date:  2010-05-14       Impact factor: 4.979

9.  A fluorometric assay for the measurement of nitrite in biological samples.

Authors:  T P Misko; R J Schilling; D Salvemini; W M Moore; M G Currie
Journal:  Anal Biochem       Date:  1993-10       Impact factor: 3.365

10.  Peptide nucleic acid synthesis by novel amide formation.

Authors:  Hyunil Lee; Jae Hoon Jeon; Jong Chan Lim; Hoon Choi; Yeohong Yoon; Sung Kee Kim
Journal:  Org Lett       Date:  2007-07-28       Impact factor: 6.005
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  14 in total

1.  Changes in microglial inflammation-related and brain-enriched MicroRNAs expressions in response to in vitro oxygen-glucose deprivation.

Authors:  Huimin Kong; Ahmed Omran; Muhammad Usman Ashhab; Na Gan; Jing Peng; Fang He; Liwen Wu; Xiaolu Deng; Fei Yin
Journal:  Neurochem Res       Date:  2013-12-12       Impact factor: 3.996

2.  Inhibition of MicroRNA-221 Alleviates Neuropathic Pain Through Targeting Suppressor of Cytokine Signaling 1.

Authors:  Li Xia; Yunlong Zhang; Tieli Dong
Journal:  J Mol Neurosci       Date:  2016-04-08       Impact factor: 3.444

Review 3.  MiRNA inhibition in tissue engineering and regenerative medicine.

Authors:  Kelsey R Beavers; Christopher E Nelson; Craig L Duvall
Journal:  Adv Drug Deliv Rev       Date:  2014-12-29       Impact factor: 15.470

4.  Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221.

Authors:  Eleonora Brognara; Enrica Fabbri; Elena Bazzoli; Giulia Montagner; Claudio Ghimenton; Albino Eccher; Cinzia Cantù; Alex Manicardi; Nicoletta Bianchi; Alessia Finotti; Giulia Breveglieri; Monica Borgatti; Roberto Corradini; Valentino Bezzerri; Giulio Cabrini; Roberto Gambari
Journal:  J Neurooncol       Date:  2014-03-05       Impact factor: 4.130

5.  Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Authors:  Kelsey R Beavers; Thomas A Werfel; Tianwei Shen; Taylor E Kavanaugh; Kameron V Kilchrist; Jeremy W Mares; Joshua S Fain; Carrie B Wiese; Kasey C Vickers; Sharon M Weiss; Craig L Duvall
Journal:  Adv Mater       Date:  2016-07-06       Impact factor: 30.849

Review 6.  Balancing the immune response in the brain: IL-10 and its regulation.

Authors:  Diogo Lobo-Silva; Guilhermina M Carriche; A Gil Castro; Susana Roque; Margarida Saraiva
Journal:  J Neuroinflammation       Date:  2016-11-24       Impact factor: 8.322

7.  Capturing intracellular oncogenic microRNAs with self-assembled DNA nanostructures for microRNA-based cancer therapy.

Authors:  Q Liu; D Wang; M Yuan; B F He; J Li; C Mao; G S Wang; H Qian
Journal:  Chem Sci       Date:  2018-08-08       Impact factor: 9.825

8.  A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells.

Authors:  Enrica Fabbri; Anna Tamanini; Tiziana Jakova; Jessica Gasparello; Alex Manicardi; Roberto Corradini; Giuseppe Sabbioni; Alessia Finotti; Monica Borgatti; Ilaria Lampronti; Silvia Munari; Maria Cristina Dechecchi; Giulio Cabrini; Roberto Gambari
Journal:  Molecules       Date:  2017-12-29       Impact factor: 4.411

9.  Exploitation of a very small peptide nucleic acid as a new inhibitor of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression.

Authors:  Felice Amato; Rossella Tomaiuolo; Fabrizia Nici; Nicola Borbone; Ausilia Elce; Bruno Catalanotti; Stefano D'Errico; Carmine Marco Morgillo; Giuseppe De Rosa; Laura Mayol; Gennaro Piccialli; Giorgia Oliviero; Giuseppe Castaldo
Journal:  Biomed Res Int       Date:  2014-04-15       Impact factor: 3.411

10.  Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti‑tubulin tetrahydrothieno[2,3‑c]pyridine derivative and a peptide nucleic acid targeting miR‑221‑3p.

Authors:  Matteo Zurlo; Romeo Romagnoli; Paola Oliva; Jessica Gasparello; Alessia Finotti; Roberto Gambari
Journal:  Int J Oncol       Date:  2021-07-19       Impact factor: 5.650
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