Literature DB >> 24737409

Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix.

Hongbo Zhang1, Dongfei Liu, Mohammad-Ali Shahbazi, Ermei Mäkilä, Bárbara Herranz-Blanco, Jarno Salonen, Jouni Hirvonen, Hélder A Santos.   

Abstract

A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  colon targeted drug delivery; microfluidics; mucoadhesion; pH-responsive microcomposite; porous silicon

Mesh：

Substances：

Year:  2014        PMID： 24737409     DOI： 10.1002/adma.201400953

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  21 in total

1.  Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy.

Authors:  Sazid Hussain; Jinmyoung Joo; Jinyoung Kang; Byungji Kim; Gary B Braun; Zhi-Gang She; Dokyoung Kim; Aman P Mann; Tarmo Mölder; Tambet Teesalu; Santina Carnazza; Salvatore Guglielmino; Michael J Sailor; Erkki Ruoslahti
Journal:  Nat Biomed Eng       Date:  2018-01-22       Impact factor: 25.671

2.  Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression.

Authors:  Hongbo Zhang; Wenguo Cui; Xiangmeng Qu; Huayin Wu; Liangliang Qu; Xu Zhang; Ermei Mäkilä; Jarno Salonen; Yueqi Zhu; Zhou Yang; Dong Chen; Hélder A Santos; Mingtan Hai; David A Weitz
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-29       Impact factor: 11.205

3.  Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites.

Authors:  Myat Noe Hsu; Rongcong Luo; Kerwin Zeming Kwek; Yong Chen Por; Yong Zhang; Chia-Hung Chen
Journal:  Biomicrofluidics       Date:  2015-03-24       Impact factor: 2.800

4.  Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization.

Authors:  Jonathan M Zuidema; Tushar Kumeria; Dokyoung Kim; Jinyoung Kang; Joanna Wang; Geoffrey Hollett; Xuan Zhang; David S Roberts; Nicole Chan; Cari Dowling; Elena Blanco-Suarez; Nicola J Allen; Mark H Tuszynski; Michael J Sailor
Journal:  Adv Mater       Date:  2018-01-24       Impact factor: 30.849

5.  Acoustofluidic coating of particles and cells.

Authors:  Bugra Ayan; Adem Ozcelik; Hunter Bachman; Shi-Yang Tang; Yuliang Xie; Mengxi Wu; Peng Li; Tony Jun Huang
Journal:  Lab Chip       Date:  2016-11-01       Impact factor: 6.799

Review 6.  Nanoparticle-hydrogel superstructures for biomedical applications.

Authors:  Yao Jiang; Nishta Krishnan; Jiyoung Heo; Ronnie H Fang; Liangfang Zhang
Journal:  J Control Release       Date:  2020-05-26       Impact factor: 9.776

Review 7.  Microfluidic fabrication of microparticles for biomedical applications.

Authors:  Wen Li; Liyuan Zhang; Xuehui Ge; Biyi Xu; Weixia Zhang; Liangliang Qu; Chang-Hyung Choi; Jianhong Xu; Afang Zhang; Hyomin Lee; David A Weitz
Journal:  Chem Soc Rev       Date:  2018-07-30       Impact factor: 54.564

8.  Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Authors:  Kelsey R Beavers; Thomas A Werfel; Tianwei Shen; Taylor E Kavanaugh; Kameron V Kilchrist; Jeremy W Mares; Joshua S Fain; Carrie B Wiese; Kasey C Vickers; Sharon M Weiss; Craig L Duvall
Journal:  Adv Mater       Date:  2016-07-06       Impact factor: 30.849

Review 9.  Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools.

Authors:  Leila Pourtalebi Jahromi; Mohammad-Ali Shahbazi; Aziz Maleki; Amir Azadi; Hélder A Santos
Journal:  Adv Sci (Weinh)       Date:  2021-03-01       Impact factor: 16.806

10.  Boston Ivy-Inspired Disc-Like Adhesive Microparticles for Drug Delivery.

Authors:  Lijun Cai; Guopu Chen; Yuetong Wang; Cheng Zhao; Luoran Shang; Yuanjin Zhao
Journal:  Research (Wash D C)       Date:  2021-05-17
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