| Literature DB >> 31637450 |
Sanda Boca1,2, Diana Gulei3, Alina-Andreea Zimta3, Anca Onaciu3, Lorand Magdo2, Adrian Bogdan Tigu3, Calin Ionescu4,5, Alexandru Irimie6,7, Rares Buiga8, Ioana Berindan-Neagoe9,10,11.
Abstract
Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer therapies have been raised. The answer to this problem may come from the world of nanoparticles such as liposomes, exosomes, polymers, dendrimers, mesoporous silica nanoparticles, quantum dots and metal-based nanoparticles which have been proved as versatile and valuable vehicles for many biomolecules including miRNAs. In another train of thoughts, the general scheme of miRNA modulation consists in inhibition of oncomiRNA expression and restoration of tumor suppressor ones. The codelivery of two miRNAs or miRNAs in combination with chemotherapeutics or small molecules was also proposed. The present review presents the latest advancements in miRNA delivery based on nanoparticle-related strategies.Entities:
Keywords: Cancer; Nanodelivery; Nanoparticles; miRNA therapy
Mesh：
Substances：
Year: 2019 PMID： 31637450 DOI： 10.1007/s00018-019-03317-9
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261