Literature DB >> 27351695

m(6)A: Signaling for mRNA splicing.

Samir Adhikari1, Wen Xiao1, Yong-Liang Zhao2, Yun-Gui Yang1.   

Abstract

Among myriads of distinct chemical modifications in RNAs, dynamic N6-methyladenosine (m(6)A) is one of the most prevalent modifications in eukaryotic mRNAs and non-coding RNAs. Similar to the critical role of chemical modifications in regulation of DNA and protein activities, RNA m(6)A modification is also observed to be involved in the regulation of diverse functions of RNAs including meiosis, fertility, development, cell reprogramming and circadian period. The RNA m(6)A modification is recognized by YTH domain containing family proteins comprising of YTHDC1-2 and YTHDF1-3. Here we focus on the nuclear m(6)A reader YTHDC1 and its regulatory role in alternative splicing and other RNA metabolic processes.

Entities:  

Keywords:  Alternative splicing; SRSF10; SRSF3; YTHDC1; m6A

Mesh：

Substances：

Year:  2016        PMID： 27351695      PMCID： PMC5013988          DOI： 10.1080/15476286.2016.1201628

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  28 in total

1.  N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Authors:  Xiao Wang; Boxuan Simen Zhao; Ian A Roundtree; Zhike Lu; Dali Han; Honghui Ma; Xiaocheng Weng; Kai Chen; Hailing Shi; Chuan He
Journal:  Cell       Date:  2015-06-04       Impact factor: 41.582

Review 2.  RNA nucleotide methylation.

Authors:  Yuri Motorin; Mark Helm
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-03-23       Impact factor: 9.957

3.  Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.

Authors:  Tingting Zhu; Ian A Roundtree; Ping Wang; Xiao Wang; Li Wang; Chang Sun; Yuan Tian; Jie Li; Chuan He; Yanhui Xu
Journal:  Cell Res       Date:  2014-11-21       Impact factor: 25.617

4.  Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Authors:  Kate D Meyer; Yogesh Saletore; Paul Zumbo; Olivier Elemento; Christopher E Mason; Samie R Jaffrey
Journal:  Cell       Date:  2012-05-17       Impact factor: 41.582

5.  5' UTR m(6)A Promotes Cap-Independent Translation.

Authors:  Kate D Meyer; Deepak P Patil; Jun Zhou; Alexandra Zinoviev; Maxim A Skabkin; Olivier Elemento; Tatyana V Pestova; Shu-Bing Qian; Samie R Jaffrey
Journal:  Cell       Date:  2015-10-22       Impact factor: 41.582

6.  ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

Authors:  Guanqun Zheng; John Arne Dahl; Yamei Niu; Peter Fedorcsak; Chun-Min Huang; Charles J Li; Cathrine B Vågbø; Yue Shi; Wen-Ling Wang; Shu-Hui Song; Zhike Lu; Ralph P G Bosmans; Qing Dai; Ya-Juan Hao; Xin Yang; Wen-Ming Zhao; Wei-Min Tong; Xiu-Jie Wang; Florian Bogdan; Kari Furu; Ye Fu; Guifang Jia; Xu Zhao; Jun Liu; Hans E Krokan; Arne Klungland; Yun-Gui Yang; Chuan He
Journal:  Mol Cell       Date:  2012-11-21       Impact factor: 17.970

7.  N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Authors:  Guifang Jia; Ye Fu; Xu Zhao; Qing Dai; Guanqun Zheng; Ying Yang; Chengqi Yi; Tomas Lindahl; Tao Pan; Yun-Gui Yang; Chuan He
Journal:  Nat Chem Biol       Date:  2011-10-16       Impact factor: 15.040

8.  The ER repeat protein YT521-B localizes to a novel subnuclear compartment.

Authors:  O Nayler; A M Hartmann; S Stamm
Journal:  J Cell Biol       Date:  2000-09-04       Impact factor: 10.539

9.  FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

Authors:  Xu Zhao; Ying Yang; Bao-Fa Sun; Yue Shi; Xin Yang; Wen Xiao; Ya-Juan Hao; Xiao-Li Ping; Yu-Sheng Chen; Wen-Jia Wang; Kang-Xuan Jin; Xing Wang; Chun-Min Huang; Yu Fu; Xiao-Meng Ge; Shu-Hui Song; Hyun Seok Jeong; Hiroyuki Yanagisawa; Yamei Niu; Gui-Fang Jia; Wei Wu; Wei-Min Tong; Akimitsu Okamoto; Chuan He; Jannie M Rendtlew Danielsen; Xiu-Jie Wang; Yun-Gui Yang
Journal:  Cell Res       Date:  2014-11-21       Impact factor: 25.617

10.  N6-methyladenosine-dependent regulation of messenger RNA stability.

Authors:  Xiao Wang; Zhike Lu; Adrian Gomez; Gary C Hon; Yanan Yue; Dali Han; Ye Fu; Marc Parisien; Qing Dai; Guifang Jia; Bing Ren; Tao Pan; Chuan He
Journal:  Nature       Date:  2013-11-27       Impact factor: 49.962
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  48 in total

Review 1.  Alternative splicing of lncRNAs in human diseases.

Authors:  Jiaxi Chen; Yawen Liu; Jingyu Min; Huizhi Wang; Feifan Li; Chunhui Xu; Aihua Gong; Min Xu
Journal:  Am J Cancer Res       Date:  2021-03-01       Impact factor: 6.166

2.  Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication.

Authors:  Fengchun Ye; E Ricky Chen; Timothy W Nilsen
Journal:  J Virol       Date:  2017-07-27       Impact factor: 5.103

Review 3.  Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family.

Authors:  Baofang Xu; Dongyang Liu; Zerong Wang; Ruixia Tian; Yongchun Zuo
Journal:  Cell Mol Life Sci       Date:  2020-07-08       Impact factor: 9.261

4.  m6A-dependent biogenesis of circular RNAs in male germ cells.

Authors:  Chong Tang; Yeming Xie; Tian Yu; Na Liu; Zhuqing Wang; Rebekah J Woolsey; Yunge Tang; Xinzong Zhang; Weibing Qin; Ying Zhang; Ge Song; Weiwei Zheng; Juan Wang; Weitian Chen; Xiongyi Wei; Zhe Xie; Rachel Klukovich; Huili Zheng; David R Quilici; Wei Yan
Journal:  Cell Res       Date:  2020-02-11       Impact factor: 25.617

Review 5.  Human m6A writers: Two subunits, 2 roles.

Authors:  Xiang Wang; Jinbo Huang; Tingting Zou; Ping Yin
Journal:  RNA Biol       Date:  2017-01-25       Impact factor: 4.652

Review 6.  Functions of RNA N6-methyladenosine modification in cancer progression.

Authors:  Bing Chen; Ya Li; Ruifeng Song; Chen Xue; Feng Xu
Journal:  Mol Biol Rep       Date:  2019-02-20       Impact factor: 2.316

Review 7.  Functions of RNA N6-methyladenosine modification in cancer progression.

Authors:  Bing Chen; Ya Li; Ruifeng Song; Chen Xue; Feng Xu
Journal:  Mol Biol Rep       Date:  2019-03-25       Impact factor: 2.316

8.  Unraveling the RNA modification code with mass spectrometry.

Authors:  Richard Lauman; Benjamin A Garcia
Journal:  Mol Omics       Date:  2020-04-14

9.  Genome-wide identification and expression analysis of YTH domain-containing RNA-binding protein family in cucumber (Cucumis sativus).

Authors:  Yong Zhou; Lifang Hu; Lunwei Jiang; Shiqiang Liu
Journal:  Genes Genomics       Date:  2018-02-03       Impact factor: 1.839

10.  Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics.

Authors:  Qing-Rong Liu; Nicholas S Huang; Hong Qu; Jennifer F O'Connell; Isabel Gonzalez-Mariscal; Sara Santa-Cruz-Calvo; Maire E Doyle; Zheng-Xiong Xi; Yun Wang; Emmanuel S Onaivi; Josephine M Egan
Journal:  Acta Pharmacol Sin       Date:  2018-09-10       Impact factor: 6.150
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