Literature DB >> 27333914

Ebola Laboratory Response at the Eternal Love Winning Africa Campus, Monrovia, Liberia, 2014-2015.

Emmie de Wit1, Kyle Rosenke1, Robert J Fischer1, Andrea Marzi1, Joseph Prescott1, Trenton Bushmaker1, Neeltje van Doremalen1, Shannon L Emery2, Darryl Falzarano1, Friederike Feldmann3, Allison Groseth1, Thomas Hoenen1, Bonventure Juma4, Kristin L McNally1, Melvin Ochieng5, Victor Omballa5, Clayton O Onyango4, Collins Owuor5, Thomas Rowe2, David Safronetz1, Joshua Self2, Brandi N Williamson1, Galina Zemtsova2, Allen Grolla6, Gary Kobinger6, Mark Rayfield2, Ute Ströher2, James E Strong6, Sonja M Best1, Hideki Ebihara1, Kathryn C Zoon7, Stuart T Nichol2, Tolbert G Nyenswah8, Fatorma K Bolay9, Moses Massaquoi8, Heinz Feldmann1, Barry Fields4.   

Abstract

West Africa experienced the first epidemic of Ebola virus infection, with by far the greatest number of cases in Guinea, Sierra Leone, and Liberia. The unprecedented epidemic triggered an unparalleled response, including the deployment of multiple Ebola treatment units and mobile/field diagnostic laboratories. The National Institute of Allergy and Infectious Diseases and the Centers for Disease Control and Prevention deployed a joint laboratory to Monrovia, Liberia, in August 2014 to support the newly founded Ebola treatment unit at the Eternal Love Winning Africa (ELWA) campus. The laboratory operated initially out of a tent structure but quickly moved into a fixed-wall building owing to severe weather conditions, the need for increased security, and the high sample volume. Until May 2015, when the laboratory closed, the site handled close to 6000 clinical specimens for Ebola virus diagnosis and supported the medical staff in case patient management. Laboratory operation and safety, as well as Ebola virus diagnostic assays, are described and discussed; in addition, lessons learned for future deployments are reviewed. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Entities:  

Keywords:  Ebola virus; West Africa; diagnostics; epidemic; mobile laboratory

Mesh:

Year:  2016        PMID: 27333914      PMCID: PMC5050467          DOI: 10.1093/infdis/jiw216

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  24 in total

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Journal:  N Engl J Med       Date:  2015-10-14       Impact factor: 91.245

Review 5.  Ebola haemorrhagic fever.

Authors:  Heinz Feldmann; Thomas W Geisbert
Journal:  Lancet       Date:  2011-03-05       Impact factor: 79.321

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Journal:  Emerg Infect Dis       Date:  2016-02       Impact factor: 6.883

8.  The Merits of Malaria Diagnostics during an Ebola Virus Disease Outbreak.

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Journal:  Emerg Infect Dis       Date:  2016-02       Impact factor: 6.883

9.  Ebola and Its Control in Liberia, 2014-2015.

Authors:  Tolbert G Nyenswah; Francis Kateh; Luke Bawo; Moses Massaquoi; Miatta Gbanyan; Mosoka Fallah; Thomas K Nagbe; Kollie K Karsor; C Sanford Wesseh; Sonpon Sieh; Alex Gasasira; Peter Graaff; Lisa Hensley; Hans Rosling; Terrence Lo; Satish K Pillai; Neil Gupta; Joel M Montgomery; Ray L Ransom; Desmond Williams; A Scott Laney; Kim A Lindblade; Laurence Slutsker; Jana L Telfer; Athalia Christie; Frank Mahoney; Kevin M De Cock
Journal:  Emerg Infect Dis       Date:  2016-02       Impact factor: 6.883

10.  Ebola virus is unlikely to become endemic in West Africa.

Authors:  Armand Sprecher; Heinz Feldmann; Lisa E Hensley; Gary Kobinger; Stuart T Nichol; Jim Strong; Michel Van Herp
Journal:  Nat Microbiol       Date:  2016-02-24       Impact factor: 17.745

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  18 in total

1.  Clinical Chemistry of Patients With Ebola in Monrovia, Liberia.

Authors:  Emmie de Wit; Shelby Kramer; Joseph Prescott; Kyle Rosenke; Darryl Falzarano; Andrea Marzi; Robert J Fischer; David Safronetz; Thomas Hoenen; Allison Groseth; Neeltje van Doremalen; Trenton Bushmaker; Kristin L McNally; Friederike Feldmann; Brandi N Williamson; Sonja M Best; Hideki Ebihara; Igor A C Damiani; Brett Adamson; Kathryn C Zoon; Tolbert G Nyenswah; Fatorma K Bolay; Moses Massaquoi; Armand Sprecher; Heinz Feldmann; Vincent J Munster
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2.  The Crux of Ebola Diagnostics.

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5.  Plasmodium Parasitemia Associated With Increased Survival in Ebola Virus-Infected Patients.

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6.  The Effect of Plasmodium on the Outcome of Ebola Virus Infection in a Mouse Model.

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7.  Diagnostic Laboratories' Capacities and Preparedness for Emerging Viral Diseases in Guinea and Mali.

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10.  Establishing Ebola Virus Disease (EVD) diagnostics using GeneXpert technology at a mobile laboratory in Liberia: Impact on outbreak response, case management and laboratory systems strengthening.

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