| Literature DB >> 27333914 |
Emmie de Wit1, Kyle Rosenke1, Robert J Fischer1, Andrea Marzi1, Joseph Prescott1, Trenton Bushmaker1, Neeltje van Doremalen1, Shannon L Emery2, Darryl Falzarano1, Friederike Feldmann3, Allison Groseth1, Thomas Hoenen1, Bonventure Juma4, Kristin L McNally1, Melvin Ochieng5, Victor Omballa5, Clayton O Onyango4, Collins Owuor5, Thomas Rowe2, David Safronetz1, Joshua Self2, Brandi N Williamson1, Galina Zemtsova2, Allen Grolla6, Gary Kobinger6, Mark Rayfield2, Ute Ströher2, James E Strong6, Sonja M Best1, Hideki Ebihara1, Kathryn C Zoon7, Stuart T Nichol2, Tolbert G Nyenswah8, Fatorma K Bolay9, Moses Massaquoi8, Heinz Feldmann1, Barry Fields4.
Abstract
West Africa experienced the first epidemic of Ebola virus infection, with by far the greatest number of cases in Guinea, Sierra Leone, and Liberia. The unprecedented epidemic triggered an unparalleled response, including the deployment of multiple Ebola treatment units and mobile/field diagnostic laboratories. The National Institute of Allergy and Infectious Diseases and the Centers for Disease Control and Prevention deployed a joint laboratory to Monrovia, Liberia, in August 2014 to support the newly founded Ebola treatment unit at the Eternal Love Winning Africa (ELWA) campus. The laboratory operated initially out of a tent structure but quickly moved into a fixed-wall building owing to severe weather conditions, the need for increased security, and the high sample volume. Until May 2015, when the laboratory closed, the site handled close to 6000 clinical specimens for Ebola virus diagnosis and supported the medical staff in case patient management. Laboratory operation and safety, as well as Ebola virus diagnostic assays, are described and discussed; in addition, lessons learned for future deployments are reviewed. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.Entities:
Keywords: Ebola virus; West Africa; diagnostics; epidemic; mobile laboratory
Mesh:
Year: 2016 PMID: 27333914 PMCID: PMC5050467 DOI: 10.1093/infdis/jiw216
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226