Literature DB >> 27471319

Clinical Chemistry of Patients With Ebola in Monrovia, Liberia.

Emmie de Wit1, Shelby Kramer1, Joseph Prescott1, Kyle Rosenke1, Darryl Falzarano1, Andrea Marzi1, Robert J Fischer1, David Safronetz1, Thomas Hoenen1, Allison Groseth1, Neeltje van Doremalen1, Trenton Bushmaker1, Kristin L McNally1, Friederike Feldmann1, Brandi N Williamson1, Sonja M Best1, Hideki Ebihara1, Igor A C Damiani2, Brett Adamson2, Kathryn C Zoon3, Tolbert G Nyenswah4, Fatorma K Bolay5, Moses Massaquoi4, Armand Sprecher2, Heinz Feldmann1, Vincent J Munster1.   

Abstract

The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eternal Love Winning Africa (ELWA) outbreak diagnostic laboratory, established in Monrovia, Liberia, to provide Ebola virus and Plasmodium spp. diagnostics during the Ebola epidemic, implemented clinical chemistry analyzers in December 2014. Clinical chemistry testing was performed for 68 patients in triage, including 12 patients infected with Ebola virus and 18 infected with Plasmodium spp. The main distinguishing feature in clinical chemistry of Ebola virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase levels and the decrease in calcium. The implementation of clinical chemistry is probably most helpful when the medical supportive care implemented at the Ebola treatment unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers can be used to monitor electrolyte balance. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Entities:  

Keywords:  Ebola virus; West Africa; clinical chemistry

Mesh：

Substances：

Year:  2016        PMID： 27471319      PMCID： PMC5050461          DOI： 10.1093/infdis/jiw187

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  9 in total

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2.  Ebola virus disease in West Africa--clinical manifestations and management.

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3.  Ebola care and research protocols.

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4.  Doing today's work superbly well--treating Ebola with current tools.

Authors:  François Lamontagne; Christophe Clément; Thomas Fletcher; Shevin T Jacob; William A Fischer; Robert A Fowler
Journal:  N Engl J Med       Date:  2014-09-24       Impact factor: 91.245

5.  Clinical illness and outcomes in patients with Ebola in Sierra Leone.

Authors:  John S Schieffelin; Jeffrey G Shaffer; Augustine Goba; Michael Gbakie; Stephen K Gire; Andres Colubri; Rachel S G Sealfon; Lansana Kanneh; Alex Moigboi; Mambu Momoh; Mohammed Fullah; Lina M Moses; Bethany L Brown; Kristian G Andersen; Sarah Winnicki; Stephen F Schaffner; Daniel J Park; Nathan L Yozwiak; Pan-Pan Jiang; David Kargbo; Simbirie Jalloh; Mbalu Fonnie; Vandi Sinnah; Issa French; Alice Kovoma; Fatima K Kamara; Veronica Tucker; Edwin Konuwa; Josephine Sellu; Ibrahim Mustapha; Momoh Foday; Mohamed Yillah; Franklyn Kanneh; Sidiki Saffa; James L B Massally; Matt L Boisen; Luis M Branco; Mohamed A Vandi; Donald S Grant; Christian Happi; Sahr M Gevao; Thomas E Fletcher; Robert A Fowler; Daniel G Bausch; Pardis C Sabeti; S Humarr Khan; Robert F Garry
Journal:  N Engl J Med       Date:  2014-10-29       Impact factor: 91.245

6.  Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus.

Authors:  Pierre E Rollin; Daniel G Bausch; Anthony Sanchez
Journal:  J Infect Dis       Date:  2007-11-15       Impact factor: 5.226

7.  Ebola Laboratory Response at the Eternal Love Winning Africa Campus, Monrovia, Liberia, 2014-2015.

Authors:  Emmie de Wit; Kyle Rosenke; Robert J Fischer; Andrea Marzi; Joseph Prescott; Trenton Bushmaker; Neeltje van Doremalen; Shannon L Emery; Darryl Falzarano; Friederike Feldmann; Allison Groseth; Thomas Hoenen; Bonventure Juma; Kristin L McNally; Melvin Ochieng; Victor Omballa; Clayton O Onyango; Collins Owuor; Thomas Rowe; David Safronetz; Joshua Self; Brandi N Williamson; Galina Zemtsova; Allen Grolla; Gary Kobinger; Mark Rayfield; Ute Ströher; James E Strong; Sonja M Best; Hideki Ebihara; Kathryn C Zoon; Stuart T Nichol; Tolbert G Nyenswah; Fatorma K Bolay; Moses Massaquoi; Heinz Feldmann; Barry Fields
Journal:  J Infect Dis       Date:  2016-06-21       Impact factor: 5.226

8.  Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.

Authors:  Daouda Sissoko; Cedric Laouenan; Elin Folkesson; Abdoul-Bing M'Lebing; Abdoul-Habib Beavogui; Sylvain Baize; Alseny-Modet Camara; Piet Maes; Susan Shepherd; Christine Danel; Sara Carazo; Mamoudou N Conde; Jean-Luc Gala; Géraldine Colin; Hélène Savini; Joseph Akoi Bore; Frederic Le Marcis; Fara Raymond Koundouno; Frédéric Petitjean; Marie-Claire Lamah; Sandra Diederich; Alexis Tounkara; Geertrui Poelart; Emmanuel Berbain; Jean-Michel Dindart; Sophie Duraffour; Annabelle Lefevre; Tamba Leno; Olivier Peyrouset; Léonid Irenge; N'Famara Bangoura; Romain Palich; Julia Hinzmann; Annette Kraus; Thierno Sadou Barry; Sakoba Berette; André Bongono; Mohamed Seto Camara; Valérie Chanfreau Munoz; Lanciné Doumbouya; Patient Mumbere Kighoma; Fara Roger Koundouno; Cécé Moriba Loua; Vincent Massala; Kinda Moumouni; Célia Provost; Nenefing Samake; Conde Sekou; Abdoulaye Soumah; Isabelle Arnould; Michel Saa Komano; Lina Gustin; Carlotta Berutto; Diarra Camara; Fodé Saydou Camara; Joliene Colpaert; Léontine Delamou; Lena Jansson; Etienne Kourouma; Maurice Loua; Kristian Malme; Emma Manfrin; André Maomou; Adele Milinouno; Sien Ombelet; Aboubacar Youla Sidiboun; Isabelle Verreckt; Pauline Yombouno; Anne Bocquin; Caroline Carbonnelle; Thierry Carmoi; Pierre Frange; Stéphane Mely; Vinh-Kim Nguyen; Delphine Pannetier; Anne-Marie Taburet; Jean-Marc Treluyer; Jacques Kolie; Raoul Moh; Minerva Cervantes Gonzalez; Eeva Kuisma; Britta Liedigk; Didier Ngabo; Martin Rudolf; Ruth Thom; Romy Kerber; Martin Gabriel; Antonino Di Caro; Roman Wölfel; Jamal Badir; Mostafa Bentahir; Yann Deccache; Catherine Dumont; Jean-François Durant; Karim El Bakkouri; Marie Gasasira Uwamahoro; Benjamin Smits; Nora Toufik; Stéphane Van Cauwenberghe; Khaled Ezzedine; Eric D'Ortenzio; Eric Dortenzio; Louis Pizarro; Aurélie Etienne; Jérémie Guedj; Alexandra Fizet; Eric Barte de Sainte Fare; Bernadette Murgue; Tuan Tran-Minh; Christophe Rapp; Pascal Piguet; Marc Poncin; Bertrand Draguez; Thierry Allaford Duverger; Solenne Barbe; Guillaume Baret; Isabelle Defourny; Miles Carroll; Hervé Raoul; Augustin Augier; Serge P Eholie; Yazdan Yazdanpanah; Claire Levy-Marchal; Annick Antierrens; Michel Van Herp; Stephan Günther; Xavier de Lamballerie; Sakoba Keïta; France Mentre; Xavier Anglaret; Denis Malvy
Journal:  PLoS Med       Date:  2016-03-01       Impact factor: 11.069

9.  The Merits of Malaria Diagnostics during an Ebola Virus Disease Outbreak.

Authors:  Emmie de Wit; Darryl Falzarano; Clayton Onyango; Kyle Rosenke; Andrea Marzi; Melvin Ochieng; Bonventure Juma; Robert J Fischer; Joseph B Prescott; David Safronetz; Victor Omballa; Collins Owuor; Thomas Hoenen; Allison Groseth; Neeltje van Doremalen; Galina Zemtsova; Joshua Self; Trenton Bushmaker; Kristin McNally; Thomas Rowe; Shannon L Emery; Friederike Feldmann; Brandi Williamson; Tolbert G Nyenswah; Allen Grolla; James E Strong; Gary Kobinger; Ute Stroeher; Mark Rayfield; Fatorma K Bolay; Kathryn C Zoon; Jorgen Stassijns; Livia Tampellini; Martin de Smet; Stuart T Nichol; Barry Fields; Armand Sprecher; Heinz Feldmann; Moses Massaquoi; Vincent J Munster
Journal:  Emerg Infect Dis       Date:  2016-02       Impact factor: 6.883
  9 in total
  5 in total

Review 1.  Insights from clinical research completed during the west Africa Ebola virus disease epidemic.

Authors:  Amanda Rojek; Peter Horby; Jake Dunning
Journal:  Lancet Infect Dis       Date:  2017-04-28       Impact factor: 25.071

2.  Ebola Laboratory Response at the Eternal Love Winning Africa Campus, Monrovia, Liberia, 2014-2015.

Authors:  Emmie de Wit; Kyle Rosenke; Robert J Fischer; Andrea Marzi; Joseph Prescott; Trenton Bushmaker; Neeltje van Doremalen; Shannon L Emery; Darryl Falzarano; Friederike Feldmann; Allison Groseth; Thomas Hoenen; Bonventure Juma; Kristin L McNally; Melvin Ochieng; Victor Omballa; Clayton O Onyango; Collins Owuor; Thomas Rowe; David Safronetz; Joshua Self; Brandi N Williamson; Galina Zemtsova; Allen Grolla; Gary Kobinger; Mark Rayfield; Ute Ströher; James E Strong; Sonja M Best; Hideki Ebihara; Kathryn C Zoon; Stuart T Nichol; Tolbert G Nyenswah; Fatorma K Bolay; Moses Massaquoi; Heinz Feldmann; Barry Fields
Journal:  J Infect Dis       Date:  2016-06-21       Impact factor: 5.226

3.  Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response.

Authors:  Jessica R Spengler; Stephen R Welch; Sarah C Genzer; JoAnn Coleman-McCray; Jessica R Harmon; Stuart T Nichol; Christina F Spiropoulou
Journal:  Emerg Infect Dis       Date:  2019-06-17       Impact factor: 6.883

4.  Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study.

Authors:  Romy Kerber; Eva Lorenz; Sophie Duraffour; Daouda Sissoko; Martin Rudolf; Anna Jaeger; Sekou Ditinn Cisse; Alseny-Modet Camara; Osvaldo Miranda; Carlos M Castro; Joseph Akoi Bore; Fara Raymond Koundouno; Johanna Repits; Babak Afrough; Beate Becker-Ziaja; Julia Hinzmann; Marc Mertens; Ines Vitoriano; Christopher Hugh Logue; Jan-Peter Böttcher; Elisa Pallasch; Andreas Sachse; Amadou Bah; Mar Cabeza-Cabrerizo; Katja Nitzsche; Eeva Kuisma; Janine Michel; Tobias Holm; Elsa Gayle Zekeng; Lauren A Cowley; Isabel Garcia-Dorival; Nicole Hetzelt; Jonathan Hans Josef Baum; Jasmine Portmann; Lisa Carter; Rahel Lemma Yenamaberhan; Alvaro Camino; Theresa Enkirch; Katrin Singethan; Sarah Meisel; Antonio Mazzarelli; Abigail Kosgei; Liana Kafetzopoulou; Natasha Y Rickett; Livia Victoria Patrono; Luam Ghebreghiorghis; Ulrike Arnold; Géraldine Colin; Sylvain Juchet; Claire Levy Marchal; Jacques Seraphin Kolie; Abdoul Habib Beavogui; Stephanie Wurr; Sabrina Bockholt; Ralf Krumkamp; Jürgen May; Kilian Stoecker; Erna Fleischmann; Giuseppe Ippolito; Miles W Carroll; Lamine Koivogui; N'Faly Magassouba; Sakoba Keita; Céline Gurry; Patrick Drury; Boubacar Diallo; Pierre Formenty; Roman Wölfel; Antonino Di Caro; Martin Gabriel; Xavier Anglaret; Denis Malvy; Stephan Günther
Journal:  J Infect Dis       Date:  2019-06-19       Impact factor: 5.226

5.  Association between oral antimalarial medication administration and mortality among patients with Ebola virus disease: a multisite cohort study.

Authors:  Logan Abel; Shiromi M Perera; Derrick Yam; Stephanie Garbern; Stephen B Kennedy; Moses Massaquoi; Foday Sahr; Dayan Woldemichael; Tao Liu; Adam C Levine; Adam R Aluisio
Journal:  BMC Infect Dis       Date:  2022-01-20       Impact factor: 3.090
  5 in total

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