| Literature DB >> 26465384 |
Suzanne E Mate1, Jeffrey R Kugelman, Tolbert G Nyenswah, Jason T Ladner, Michael R Wiley, Thierry Cordier-Lassalle, Athalia Christie, Gary P Schroth, Stephen M Gross, Gloria J Davies-Wayne, Shivam A Shinde, Ratnesh Murugan, Sonpon B Sieh, Moses Badio, Lawrence Fakoli, Fahn Taweh, Emmie de Wit, Neeltje van Doremalen, Vincent J Munster, James Pettitt, Karla Prieto, Ben W Humrighouse, Ute Ströher, Joseph W DiClaro, Lisa E Hensley, Randal J Schoepp, David Safronetz, Joseph Fair, Jens H Kuhn, David J Blackley, A Scott Laney, Desmond E Williams, Terrence Lo, Alex Gasasira, Stuart T Nichol, Pierre Formenty, Francis N Kateh, Kevin M De Cock, Fatorma Bolay, Mariano Sanchez-Lockhart, Gustavo Palacios.
Abstract
A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. (Funded by the Defense Threat Reduction Agency and others.).Entities:
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Year: 2015 PMID： 26465384 PMCID： PMC4711355 DOI： 10.1056/NEJMoa1509773
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245