Literature DB >> 27312728

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets.

Anton Bespalov1, Thomas Steckler2, Bruce Altevogt3, Elena Koustova4, Phil Skolnick4, Daniel Deaver5, Mark J Millan6, Jesper F Bastlund7, Dario Doller8, Jeffrey Witkin9, Paul Moser10, Patricio O'Donnell11, Ulrich Ebert12, Mark A Geyer13, Eric Prinssen14, Theresa Ballard14, Malcolm Macleod15.   

Abstract

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Year:  2016        PMID： 27312728     DOI： 10.1038/nrd.2016.88

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  10 in total

1.  Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Authors:  Paul Morgan; Piet H Van Der Graaf; John Arrowsmith; Doug E Feltner; Kira S Drummond; Craig D Wegner; Steve D A Street
Journal:  Drug Discov Today       Date:  2011-12-29       Impact factor: 7.851

2.  Systematic variation improves reproducibility of animal experiments.

Authors:  S Helene Richter; Joseph P Garner; Corinna Auer; Joachim Kunert; Hanno Würbel
Journal:  Nat Methods       Date:  2010-03       Impact factor: 28.547

3.  The preclinical data forum network: A new ECNP initiative to improve data quality and robustness for (preclinical) neuroscience.

Authors:  Thomas Steckler; Katja Brose; Magali Haas; Martien J Kas; Elena Koustova; Anton Bespalov
Journal:  Eur Neuropsychopharmacol       Date:  2015-06-04       Impact factor: 4.600

4.  Demystifying brain penetration in central nervous system drug discovery. Miniperspective.

Authors:  Li Di; Haojing Rong; Bo Feng
Journal:  J Med Chem       Date:  2012-11-06       Impact factor: 7.446

5.  Don't stop the quest to measure Big G.

Authors:  Terry Quinn
Journal:  Nature       Date:  2014-01-23       Impact factor: 49.962

Review 6.  Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.

Authors:  David Cook; Dearg Brown; Robert Alexander; Ruth March; Paul Morgan; Gemma Satterthwaite; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2014-05-16       Impact factor: 84.694

Review 7.  Drug Tolerance: A Known Unknown in Translational Neuroscience.

Authors:  Anton Bespalov; Reinhold Müller; Ana-Lucia Relo; Thomas Hudzik
Journal:  Trends Pharmacol Sci       Date:  2016-02-28       Impact factor: 14.819

8.  Can animal models of disease reliably inform human studies?

Authors:  H Bart van der Worp; David W Howells; Emily S Sena; Michelle J Porritt; Sarah Rewell; Victoria O'Collins; Malcolm R Macleod
Journal:  PLoS Med       Date:  2010-03-30       Impact factor: 11.069

9.  Design, power, and interpretation of studies in the standard murine model of ALS.

Authors:  Sean Scott; Janice E Kranz; Jeff Cole; John M Lincecum; Kenneth Thompson; Nancy Kelly; Alan Bostrom; Jill Theodoss; Bashar M Al-Nakhala; Fernando G Vieira; Jeyanthi Ramasubbu; James A Heywood
Journal:  Amyotroph Lateral Scler       Date:  2008

10.  Why most published research findings are false.

Authors:  John P A Ioannidis
Journal:  PLoS Med       Date:  2005-08-30       Impact factor: 11.613
  10 in total
  13 in total

Review 1.  Sex differences in the hypothalamic-pituitary-adrenal axis: An obstacle to antidepressant drug development?

Authors:  Nikolaos Kokras; Georgia E Hodes; Debra A Bangasser; Christina Dalla
Journal:  Br J Pharmacol       Date:  2019-06-26       Impact factor: 8.739

Review 2.  Psychoactive drug exposure during breastfeeding: a critical need for preclinical behavioral testing.

Authors:  Irving Zucker
Journal:  Psychopharmacology (Berl)       Date:  2018-03-16       Impact factor: 4.530

3.  Chemogenetics: drug-controlled gene therapies for neural circuit disorders.

Authors:  Scott M Sternson; David Bleakman
Journal:  Cell Gene Ther Insights       Date:  2020-08

4.  Transfer of incentive salience from a first-order alcohol cue to a novel second-order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence.

Authors:  Kimberly A Fleming; Roberto U Cofresí; Bruce D Bartholow
Journal:  Addiction       Date:  2021-01-21       Impact factor: 7.256

5.  A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine.

Authors:  Ulrich Dirnagl; Ingo Przesdzing; Claudia Kurreck; Sebastian Major
Journal:  PLoS Biol       Date:  2016-12-01       Impact factor: 8.029

Review 6.  Animal models of addiction.

Authors:  Rainer Spanagel
Journal:  Dialogues Clin Neurosci       Date:  2017-09       Impact factor: 5.986

7.  Kinoscope: An Open-Source Computer Program for Behavioral Pharmacologists.

Authors:  Nikolaos Kokras; Dimitrios Baltas; Foivos Theocharis; Christina Dalla
Journal:  Front Behav Neurosci       Date:  2017-05-12       Impact factor: 3.558

8.  Stroke: The past, present and future.

Authors:  I Mhairi Macrae; Stuart M Allan
Journal:  Brain Neurosci Adv       Date:  2018

9.  Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform.

Authors:  Anup D Sharma; Laurie McCoy; Elizabeth Jacobs; Hannah Willey; Jordan Q Behn; Hieu Nguyen; Brad Bolon; J Lowry Curley; Michael J Moore
Journal:  Sci Rep       Date:  2019-06-20       Impact factor: 4.379

Review 10.  Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis.

Authors:  Susan F Sonnenschein; A Grace
Journal:  Expert Opin Ther Targets       Date:  2020-11-26       Impact factor: 6.902
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