PURPOSE: We aimed to explore the potential value of the whole tumor apparent diffusion coefficient (ADC) for discriminating between benign and malignant intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. METHODS: Forty-two patients underwent 1.5 T magnetic resonance imaging that included diffusion-weighted imaging (DWI, b=0.500 s/mm2). The mean, minimum, and maximum ADC values were measured for the whole tumor. The differences between benign and malignant IPMNs were calculated for the mean ADC, ADC-min, and ADC-max values. Receiver operating characteristics (ROC) analysis was conducted to evaluate their potential diagnostic performance. RESULTS: Fifteen of 25 benign IPMNs demonstrated low or iso-signal intensity on DWI with a b value of 500 s/mm2 compared with normal pancreatic parenchyma, whereas all malignant IPMNs demonstrated high signal intensity. The mean value of ADC was significantly higher in benign IPMNs compared with malignant IPMNs (3.39×10-3 mm2/s vs. 2.39×10-3 mm2/s, P < 0.001), with an area under the ROC curve (AUC) of 0.92 (95% confidence interval [CI], 0.79-0.98). The ADC-min value of malignant IPMNs was also significantly lower than that of benign IPMNs (1.24×10-3 mm2/s vs. 2.58×10-3 mm2/s, P < 0.001), with an AUC of 0.94 (95% CI, 0.82-0.99). No marked difference was found between benign and malignant IPMNs for the ADC-max value (3.89×10-3 mm2/s vs. 3.78×10-3 mm2/s, P = 0.299). CONCLUSION: Lower mean and minimum ADC values of the whole tumor might be potential predictors of malignant IPMNs of the pancreas.
PURPOSE: We aimed to explore the potential value of the whole tumor apparent diffusion coefficient (ADC) for discriminating between benign and malignant intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. METHODS: Forty-two patients underwent 1.5 T magnetic resonance imaging that included diffusion-weighted imaging (DWI, b=0.500 s/mm2). The mean, minimum, and maximum ADC values were measured for the whole tumor. The differences between benign and malignant IPMNs were calculated for the mean ADC, ADC-min, and ADC-max values. Receiver operating characteristics (ROC) analysis was conducted to evaluate their potential diagnostic performance. RESULTS: Fifteen of 25 benign IPMNs demonstrated low or iso-signal intensity on DWI with a b value of 500 s/mm2 compared with normal pancreatic parenchyma, whereas all malignant IPMNs demonstrated high signal intensity. The mean value of ADC was significantly higher in benign IPMNs compared with malignant IPMNs (3.39×10-3 mm2/s vs. 2.39×10-3 mm2/s, P < 0.001), with an area under the ROC curve (AUC) of 0.92 (95% confidence interval [CI], 0.79-0.98). The ADC-min value of malignant IPMNs was also significantly lower than that of benign IPMNs (1.24×10-3 mm2/s vs. 2.58×10-3 mm2/s, P < 0.001), with an AUC of 0.94 (95% CI, 0.82-0.99). No marked difference was found between benign and malignant IPMNs for the ADC-max value (3.89×10-3 mm2/s vs. 3.78×10-3 mm2/s, P = 0.299). CONCLUSION: Lower mean and minimum ADC values of the whole tumor might be potential predictors of malignant IPMNs of the pancreas.
Authors: Nieun Seo; Jae Ho Byun; Jin Hee Kim; Hyoung Jung Kim; Seung Soo Lee; Ki Byung Song; Song-Cheol Kim; Duck Jong Han; Seung-Mo Hong; Moon-Gyu Lee Journal: Ann Surg Date: 2016-03 Impact factor: 12.969
Authors: K Sandrasegaran; F M Akisik; A A Patel; M Rydberg; H M Cramer; N P Agaram; C M Schmidt Journal: Clin Radiol Date: 2011-05-20 Impact factor: 2.350
Authors: Alexandra M Roch; Morgan R Barron; Mark Tann; Kumar Sandrasegar; Katheryn N Hannaford; Eugene P Ceppa; Michael G House; Nicholas J Zyromski; Attila Nakeeb; C Maximillian Schmidt Journal: J Am Coll Surg Date: 2015-04-28 Impact factor: 6.113
Authors: Ajay V Maker; Linda S Lee; Chandrajit P Raut; Thomas E Clancy; Richard S Swanson Journal: Ann Surg Oncol Date: 2008-09-03 Impact factor: 5.344
Authors: Kwang Hyuck Lee; Se-Joon Lee; Jong Kyun Lee; Ji Kon Ryu; Eun Young Kim; Tae Hyeon Kim; Jong Ho Moon; Woo Jin Lee; Yu Kyung Cho; Jae J Kim Journal: Pancreas Date: 2014-11 Impact factor: 3.327
Authors: J Lafemina; N Katabi; D Klimstra; C Correa-Gallego; S Gaujoux; T P Kingham; R P Dematteo; Y Fong; M I D'Angelica; W R Jarnagin; R K Do; M F Brennan; Peter J Allen Journal: Ann Surg Oncol Date: 2012-10-31 Impact factor: 5.344