Literature DB >> 27273629

NMR as a tool to investigate the structure, dynamics and function of membrane proteins.

Binyong Liang1,2, Lukas K Tamm1,2.   

Abstract

Membrane-protein NMR occupies a unique niche for determining structures, assessing dynamics, examining folding, and studying the binding of lipids, ligands and drugs to membrane proteins. However, NMR analyses of membrane proteins also face special challenges that are not encountered with soluble proteins, including sample preparation, size limitation, spectral crowding and sparse data accumulation. This Perspective provides a snapshot of current achievements, future opportunities and possible limitations in this rapidly developing field.

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Year:  2016        PMID： 27273629      PMCID： PMC5444674          DOI： 10.1038/nsmb.3226

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  82 in total

1.  The Protein Data Bank.

Authors:  H M Berman; J Westbrook; Z Feng; G Gilliland; T N Bhat; H Weissig; I N Shindyalov; P E Bourne
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

2.  Structure of outer membrane protein A transmembrane domain by NMR spectroscopy.

Authors:  A Arora; F Abildgaard; J H Bushweller; L K Tamm
Journal:  Nat Struct Biol       Date:  2001-04

3.  NMR-based conformational ensembles explain pH-gated opening and closing of OmpG channel.

Authors:  Tiandi Zhuang; Christina Chisholm; Min Chen; Lukas K Tamm
Journal:  J Am Chem Soc       Date:  2013-10-01       Impact factor: 15.419

4.  β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy.

Authors:  Reto Horst; Jeffrey J Liu; Raymond C Stevens; Kurt Wüthrich
Journal:  Angew Chem Int Ed Engl       Date:  2013-08-16       Impact factor: 15.336

5.  High-resolution conformation of gramicidin A in a lipid bilayer by solid-state NMR.

Authors:  R R Ketchem; W Hu; T A Cross
Journal:  Science       Date:  1993-09-10       Impact factor: 47.728

6.  Structural basis for the interaction of lipopolysaccharide with outer membrane protein H (OprH) from Pseudomonas aeruginosa.

Authors:  Thomas C Edrington; Erica Kintz; Joanna B Goldberg; Lukas K Tamm
Journal:  J Biol Chem       Date:  2011-08-24       Impact factor: 5.157

7.  Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate.

Authors:  Lukas K Tamm; Jinwoo Lee; Binyong Liang
Journal:  Structure       Date:  2014-09-02       Impact factor: 5.006

8.  OprG Harnesses the Dynamics of its Extracellular Loops to Transport Small Amino Acids across the Outer Membrane of Pseudomonas aeruginosa.

Authors:  Iga Kucharska; Patrick Seelheim; Thomas Edrington; Binyong Liang; Lukas K Tamm
Journal:  Structure       Date:  2015-11-19       Impact factor: 5.006

9.  Intrinsic conformational plasticity of native EmrE provides a pathway for multidrug resistance.

Authors:  Min-Kyu Cho; Anindita Gayen; James R Banigan; Maureen Leninger; Nathaniel J Traaseth
Journal:  J Am Chem Soc       Date:  2014-05-23       Impact factor: 15.419

10.  Protonation of a glutamate residue modulates the dynamics of the drug transporter EmrE.

Authors:  Anindita Gayen; Maureen Leninger; Nathaniel J Traaseth
Journal:  Nat Chem Biol       Date:  2016-01-11       Impact factor: 15.040
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  29 in total

1.  Single Particle Analysis for High-Resolution 2D Electron Crystallography.

Authors:  Ricardo Righetto; Henning Stahlberg
Journal:  Methods Mol Biol       Date:  2021

Review 2.  New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors.

Authors:  Reinhard Grisshammer
Journal:  Protein Sci       Date:  2017-06-07       Impact factor: 6.725

Review 3.  Polyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins.

Authors:  Joshua G Pemberton; Tamas Balla
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

Review 4.  Recent excitements in protein NMR: Large proteins and biologically relevant dynamics.

Authors:  Sai Chaitanya Chiliveri; Mandar V Deshmukh
Journal:  J Biosci       Date:  2016-12       Impact factor: 1.826

5.  Integrating hydrogen-deuterium exchange mass spectrometry with molecular dynamics simulations to probe lipid-modulated conformational changes in membrane proteins.

Authors:  Chloe Martens; Mrinal Shekhar; Andy M Lau; Emad Tajkhorshid; Argyris Politis
Journal:  Nat Protoc       Date:  2019-10-11       Impact factor: 13.491

6.  Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.

Authors:  Igor Dikiy; Lindsay D Clark; Kevin H Gardner; Daniel M Rosenbaum
Journal:  Methods Enzymol       Date:  2018-12-18       Impact factor: 1.600

Review 7.  A comparative look at structural variation among RC-LH1 'Core' complexes present in anoxygenic phototrophic bacteria.

Authors:  Alastair T Gardiner; Tu C Nguyen-Phan; Richard J Cogdell
Journal:  Photosynth Res       Date:  2020-05-19       Impact factor: 3.573

8.  Solution NMR Provides New Insight into Lipid-Protein Interaction.

Authors:  Iga Kucharska; Lukas K Tamm
Journal:  Biochemistry       Date:  2017-06-01       Impact factor: 3.162

Review 9.  Solution NMR of SNAREs, complexin and α-synuclein in association with membrane-mimetics.

Authors:  Binyong Liang; Lukas K Tamm
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2018-02-08       Impact factor: 9.795

10.  Detergent-free extraction, reconstitution and characterization of membrane-anchored cytochrome-b5 in native lipids.

Authors:  Bankala Krishnarjuna; Thirupathi Ravula; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2020-05-28       Impact factor: 6.222
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