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Literature DB >> 23956158

β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy.

Reto Horst¹, Jeffrey J Liu, Raymond C Stevens, Kurt Wüthrich.

Abstract

Entities: Chemical Disease Gene Mutation Species

Keywords: 19F NMR spectroscopy; G-protein-coupled receptors; protein structures; β2-adrenergic receptor

Mesh：

Substances：

Year: 2013 PMID： 23956158 PMCID： PMC3925757 DOI： 10.1002/anie.201305286

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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26 in total

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3. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

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4. Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.

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Review 5. Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions.

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Journal: Chem Biol Date: 1995-11

6. Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility.

Authors: U Gether; J A Ballesteros; R Seifert; E Sanders-Bush; H Weinstein; B K Kobilka
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7. 19F NMR relaxation studies on 5-fluorotryptophan- and tetradeutero-5-fluorotryptophan-labeled E. coli glucose/galactose receptor.

Authors: L A Luck; J E Vance; T M O'Connell; R E London
Journal: J Biomol NMR Date: 1996-06 Impact factor: 2.835

8. Fluorine-19 NMR studies on the acid state of the intestinal fatty acid binding protein.

Authors: Hua Li; Carl Frieden
Journal: Biochemistry Date: 2006-05-23 Impact factor: 3.162

9. Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.

Authors: Gayathri Swaminath; Yang Xiang; Tae Weon Lee; Jacqueline Steenhuis; Charles Parnot; Brian K Kobilka
Journal: J Biol Chem Date: 2003-10-14 Impact factor: 5.157

10. Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies.

Authors: Sébastien Granier; Samuel Kim; Aaron M Shafer; Venkata R P Ratnala; Juan José Fung; Richard N Zare; Brian Kobilka
Journal: J Biol Chem Date: 2007-03-08 Impact factor: 5.157

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2. (19)F Paramagnetic Relaxation Enhancement: A Valuable Tool for Distance Measurements in Proteins.

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3. Ring current shifts in (19)F-NMR of membrane proteins.

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Review 4. Mechanistic insights into GPCR-G protein interactions.

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Journal: Curr Opin Struct Biol Date: 2016-11-18 Impact factor: 6.809

Review 5. GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.

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6. Allosteric Coupling of Drug Binding and Intracellular Signaling in the A_2A Adenosine Receptor.

Authors: Matthew T Eddy; Ming-Yue Lee; Zhan-Guo Gao; Kate L White; Tatiana Didenko; Reto Horst; Martin Audet; Pawel Stanczak; Kyle M McClary; Gye Won Han; Kenneth A Jacobson; Raymond C Stevens; Kurt Wüthrich
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7. A_2A adenosine receptor functional states characterized by ¹⁹F-NMR.

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8. Deuteration and selective labeling of alanine methyl groups of β₂-adrenergic receptor expressed in a baculovirus-insect cell expression system.

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Journal: J Biomol NMR Date: 2018-03-08 Impact factor: 2.835

9. Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

Authors: Rajan Lamichhane; Jeffrey J Liu; Goran Pljevaljcic; Kate L White; Edwin van der Schans; Vsevolod Katritch; Raymond C Stevens; Kurt Wüthrich; David P Millar
Journal: Proc Natl Acad Sci U S A Date: 2015-11-02 Impact factor: 11.205

Review 10. Structural biology of human GPCR drugs and endogenous ligands - insights from NMR spectroscopy.

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