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Literature DB >> 25185826

Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate.

Lukas K Tamm¹, Jinwoo Lee², Binyong Liang².

Abstract

Nuclear magnetic resonance (NMR) studies on an HIV gp41 construct reported by Lakomek and colleagues in this issue of Structure have revealed the conformational dynamics of a possible trimeric prehairpin fusion intermediate and its interactions with lipids. Two alternative fusion pathways are compared based on this work and a previous NMR structure of a monomeric lipid-bound gp41 ectodomain construct.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 25185826 PMCID： PMC4199205 DOI： 10.1016/j.str.2014.08.010

Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006

12 in total

1. Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate.

Authors: Binyong Liang; Volker Kiessling; Lukas K Tamm
Journal: Proc Natl Acad Sci U S A Date: 2013-11-11 Impact factor: 11.205

2. Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation.

Authors: Jeffrey F Ellena; Binyong Liang; Maciej Wiktor; Alexander Stein; David S Cafiso; Reinhard Jahn; Lukas K Tamm
Journal: Proc Natl Acad Sci U S A Date: 2009-11-16 Impact factor: 11.205

3. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.

Authors: Dmitry Lyumkis; Jean-Philippe Julien; Natalia de Val; Albert Cupo; Clinton S Potter; Per-Johan Klasse; Dennis R Burton; Rogier W Sanders; John P Moore; Bridget Carragher; Ian A Wilson; Andrew B Ward
Journal: Science Date: 2013-10-31 Impact factor: 47.728

4. Crystal structure of a soluble cleaved HIV-1 envelope trimer.

Authors: Jean-Philippe Julien; Albert Cupo; Devin Sok; Robyn L Stanfield; Dmitry Lyumkis; Marc C Deller; Per-Johan Klasse; Dennis R Burton; Rogier W Sanders; John P Moore; Andrew B Ward; Ian A Wilson
Journal: Science Date: 2013-10-31 Impact factor: 47.728

5. Atomic structure of a thermostable subdomain of HIV-1 gp41.

Authors: K Tan; J Liu; J Wang; S Shen; M Lu
Journal: Proc Natl Acad Sci U S A Date: 1997-11-11 Impact factor: 11.205

6. Atomic structure of the ectodomain from HIV-1 gp41.

Authors: W Weissenhorn; A Dessen; S C Harrison; J J Skehel; D C Wiley
Journal: Nature Date: 1997-05-22 Impact factor: 49.962

7. Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.

Authors: Julien Roche; John M Louis; Alexander Grishaev; Jinfa Ying; Adriaan Bax
Journal: Proc Natl Acad Sci U S A Date: 2014-02-18 Impact factor: 11.205

8. Core structure of gp41 from the HIV envelope glycoprotein.

Authors: D C Chan; D Fass; J M Berger; P S Kim
Journal: Cell Date: 1997-04-18 Impact factor: 41.582

9. Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales.

Authors: Nils-Alexander Lakomek; Joshua D Kaufman; Stephen J Stahl; John M Louis; Alexander Grishaev; Paul T Wingfield; Ad Bax
Journal: Angew Chem Int Ed Engl Date: 2013-02-28 Impact factor: 15.336

10. Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy.

Authors: Alberto Bartesaghi; Alan Merk; Mario J Borgnia; Jacqueline L S Milne; Sriram Subramaniam
Journal: Nat Struct Mol Biol Date: 2013-10-23 Impact factor: 15.369

11 in total

1. NMR as a tool to investigate the structure, dynamics and function of membrane proteins.

Authors: Binyong Liang; Lukas K Tamm
Journal: Nat Struct Mol Biol Date: 2016-06-07 Impact factor: 15.369

2. Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding.

Authors: Julien Roche; John M Louis; Annie Aniana; Rodolfo Ghirlando; Ad Bax
Journal: J Biomol NMR Date: 2015-01-29 Impact factor: 2.835

3. Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.

Authors: Jinwoo Lee; David A Nyenhuis; Elizabeth A Nelson; David S Cafiso; Judith M White; Lukas K Tamm
Journal: Proc Natl Acad Sci U S A Date: 2017-09-05 Impact factor: 11.205

10. Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles.

Authors: John M Louis; James L Baber; Rodolfo Ghirlando; Annie Aniana; Ad Bax; Julien Roche
Journal: PLoS One Date: 2016-08-11 Impact factor: 3.240