Carlo Fabbri1, Lorenzo Fuccio2, Adele Fornelli3, Filippo Antonini4, Rosa Liotta5, Leonardo Frazzoni2, Alberto Larghi6, Antonella Maimone7, Silvia Paggi8, Paolo Gusella9, Luca Barresi10, Anna Maria Polifemo7, Elio Iovine11, Giampiero Macarri4, Vincenzo Cennamo7, Ilaria Tarantino10. 1. Unit of Gastroenterology and Digestive Endoscopy, AUSL Bologna, Bellaria-Maggiore Hospital, 40133, Bologna, Italy. carlo.fabbri@ausl.bologna.it. 2. Division of Gastroenterology, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. 3. Pathology Service, AUSL Bologna, Bellaria-Maggiore Hospital, Bologna, Italy. 4. Department of Gastroenterology, A. Murri Hospital, Fermo, Italy. 5. Pathology Service, Department of Diagnostic and Therapeutic Services, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy. 6. Digestive Endoscopy Unit, Catholic University, Rome, Italy. 7. Unit of Gastroenterology and Digestive Endoscopy, AUSL Bologna, Bellaria-Maggiore Hospital, 40133, Bologna, Italy. 8. Gastroenterology Unit, Valduce Hospital, Como, Italy. 9. Pathology Service, A. Murri Hospital, Polytechnic University of Marche, Fermo, Italy. 10. Endoscopy Service, Department of Diagnostic and Therapeutic Services, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy. 11. Emergency and General Surgery Department, AUSL Bologna, Bellaria-Maggiore Hospital, Bologna, Italy.
Abstract
BACKGROUND: Rapid on-site evaluation (ROSE) improves the adequacy and accuracy of EUS-guided tissue acquisition, although it is not routinely widely available. Evidence suggested that core needles might overcome the absence of ROSE. The aim of this study was to evaluate the influence of ROSE on the adequacy and accuracy of EUS-guided tissue acquisition with core needles in patients with pancreatic solid lesions. METHODS: Patients who underwent EUS-guided tissue acquisition of pancreatic mass lesions were retrospectively identified at three tertiary referral centers and those performed with the core needle were included. Adequacy, defined as the rate of cases in which a tissue specimen for proper examination was achieved, with and without ROSE was the primary outcome measure. The diagnostic accuracy and tissue core acquisition were the secondary outcome measures. RESULTS: A total of 333 patients with pancreatic solid mass lesions were included in the study; 140 cases sampled with ROSE and 193 cases without ROSE. The adequacy was 92.1 % in the group sampled with ROSE and 88.1 % in the group without ROSE (p = 0.227). In the ROSE group sensitivity, specificity, and accuracy were 90.7, 100 and 92.1 %, respectively. In the group without ROSE, sensitivity, specificity, and accuracy were 87.2, 100, and 88.1 %, respectively. No difference for all these figures was observed between the two groups. The tissue core was available in 61.4 and 53.4 % of cases with and without ROSE, respectively (p = 0.143). CONCLUSION: In the absence of ROSE, EUS-based tissue acquisition with Core needle should be considered since it achieves comparable tissue sampling adequacy and accuracy.
BACKGROUND: Rapid on-site evaluation (ROSE) improves the adequacy and accuracy of EUS-guided tissue acquisition, although it is not routinely widely available. Evidence suggested that core needles might overcome the absence of ROSE. The aim of this study was to evaluate the influence of ROSE on the adequacy and accuracy of EUS-guided tissue acquisition with core needles in patients with pancreatic solid lesions. METHODS:Patients who underwent EUS-guided tissue acquisition of pancreatic mass lesions were retrospectively identified at three tertiary referral centers and those performed with the core needle were included. Adequacy, defined as the rate of cases in which a tissue specimen for proper examination was achieved, with and without ROSE was the primary outcome measure. The diagnostic accuracy and tissue core acquisition were the secondary outcome measures. RESULTS: A total of 333 patients with pancreatic solid mass lesions were included in the study; 140 cases sampled with ROSE and 193 cases without ROSE. The adequacy was 92.1 % in the group sampled with ROSE and 88.1 % in the group without ROSE (p = 0.227). In the ROSE group sensitivity, specificity, and accuracy were 90.7, 100 and 92.1 %, respectively. In the group without ROSE, sensitivity, specificity, and accuracy were 87.2, 100, and 88.1 %, respectively. No difference for all these figures was observed between the two groups. The tissue core was available in 61.4 and 53.4 % of cases with and without ROSE, respectively (p = 0.143). CONCLUSION: In the absence of ROSE, EUS-based tissue acquisition with Core needle should be considered since it achieves comparable tissue sampling adequacy and accuracy.
Authors: Priscilla A van Riet; Djuna L Cahen; Katharina Biermann; Bettina Hansen; Alberto Larghi; Guido Rindi; Giovanni Fellegara; Paolo Arcidiacono; Claudio Doglioni; Nicola Liberta Decarli; Julio Iglesias-Garcia; Ihab Abdulkader; Hector Lazare Iglesias; Masayuki Kitano; Takaaki Chikugo; Satoru Yasukawa; Hans van der Valk; Nam Quoc Nguyen; Andrew Ruszkiewicz; Marc Giovannini; Flora Poizat; Schalk van der Merwe; Tania Roskams; Erwin Santo; Silvia Marmor; Kenneth Chang; Fritz Lin; James Farrell; Marie Robert; Juan Carlos Bucobo; Alan Heimann; Francisco Baldaque-Silva; Carlos Fernández Moro; Marco J Bruno Journal: Dig Endosc Date: 2019-07-10 Impact factor: 7.559
Authors: Jintao Guo; Anand V Sahai; Anthony Teoh; Paolo Giorgio Arcidiacono; Alberto Larghi; Adrian Saftoiu; Ali A Siddiqui; Brenda Lucia Arturo Arias; Christian Jenssen; Douglas G Adler; Sundeep Lakhtakia; Dong-Wan Seo; Fumihide Itokawa; Marc Giovannini; Girish Mishra; Luis Sabbagh; Atsushi Irisawa; Julio Iglesias-Garcia; Jan Werner Poley; Juan J Vila; Lachter Jesse; Kensuke Kubota; Evangelos Kalaitzakis; Mitsuhiro Kida; Mohamed El-Nady; Sh Untaro Mukai; Takeshi Ogura; Pietro Fusaroli; Peter Vilmann; Praveer Rai; Nam Q Nguyen; Ryan Ponnudurai; Chalapathi Rao Achanta; Todd H Baron; Ichiro Yasuda; Hsiu-Po Wang; Jinlong Hu; Bowen Duan; Manoop S Bhutani; Siyu Sun Journal: Endosc Ultrasound Date: 2020 Sep-Oct Impact factor: 5.628
Authors: Benedetto Mangiavillano; Leonardo Frazzoni; Thomas Togliani; Carlo Fabbri; Ilaria Tarantino; Luca De Luca; Teresa Staiano; Cecilia Binda; Marianna Signoretti; Leonardo H Eusebi; Francesco Auriemma; Laura Lamonaca; Danilo Paduano; Milena Di Leo; Silvia Carrara; Lorenzo Fuccio; Alessandro Repici Journal: Endosc Int Open Date: 2021-05-27