| Literature DB >> 27064256 |
Chiea Chuen Khor1,2,3, Tan Do4, Hongyan Jia5, Masakazu Nakano6, Ronnie George7, Khaled Abu-Amero8,9, Roopam Duvesh10, Li Jia Chen11, Zheng Li1, Monisha E Nongpiur2, Shamira A Perera2, Chunyan Qiao5, Hon-Tym Wong12, Hiroshi Sakai13, Mônica Barbosa de Melo14, Mei-Chin Lee2, Anita S Chan2, Yaakub Azhany15, Thi Lam Huong Dao4, Yoko Ikeda16, Rodolfo A Perez-Grossmann17, Tomasz Zarnowski18, Alexander C Day19,20,21, Jost B Jonas22, Pancy O S Tam11, Tuan Anh Tran23, Humaira Ayub24, Farah Akhtar25, Shazia Micheal26, Paul T K Chew27, Leyla A Aljasim28, Tanuj Dada29, Tam Thi Luu30, Mona S Awadalla31, Naris Kitnarong32, Boonsong Wanichwecharungruang33,34, Yee Yee Aung35, Jelinar Mohamed-Noor36, Saravanan Vijayan10, Sripriya Sarangapani37, Rahat Husain2,38, Aliza Jap2,38, Mani Baskaran2, David Goh2, Daniel H Su2, Huaizhou Wang5, Vernon K Yong12, Leonard W Yip12, Tuyet Bach Trinh23, Manchima Makornwattana39, Thanh Thu Nguyen40, Edgar U Leuenberger41,42, Ki-Ho Park43, Widya Artini Wiyogo44,45, Rajesh S Kumar46, Celso Tello47, Yasuo Kurimoto48, Suman S Thapa49, Kessara Pathanapitoon50, John F Salmon51, Yong Ho Sohn52, Antonio Fea53, Mineo Ozaki54,55, Jimmy S M Lai56, Visanee Tantisevi57, Chaw Chaw Khaing58, Takanori Mizoguchi59, Satoko Nakano60, Chan-Yun Kim61, Guangxian Tang62, Sujie Fan63, Renyi Wu64, Hailin Meng65, Thi Thuy Giang Nguyen4, Tien Dat Tran4, Morio Ueno16, Jose Maria Martinez66, Norlina Ramli67,68, Yin Mon Aung69,70, Rigo Daniel Reyes71,72, Stephen A Vernon73,74, Seng Kheong Fang75, Zhicheng Xie1, Xiao Yin Chen1, Jia Nee Foo1, Kar Seng Sim1, Tina T Wong2, Desmond T Quek2, Rengaraj Venkatesh76, Srinivasan Kavitha76, Subbiah R Krishnadas77, Nagaswamy Soumittra37, Balekudaru Shantha7, Boon-Ang Lim12, Jeanne Ogle12, José P C de Vasconcellos78, Vital P Costa77, Ricardo Y Abe77, Bruno B de Souza14, Chelvin C Sng27, Maria C Aquino27, Ewa Kosior-Jarecka18, Guillermo Barreto Fong79, Vania Castro Tamanaja80, Ricardo Fujita81, Yuzhen Jiang19,20,21, Naushin Waseem19,21, Sancy Low19,20,21, Huan Nguyen Pham23, Sami Al-Shahwan28, E Randy Craven28,82, Muhammad Imran Khan83, Rrima Dada29, Kuldeep Mohanty29, Muneeb A Faiq29, Alex W Hewitt84,85, Kathryn P Burdon31,84, Eng Hui Gan36, Anuwat Prutthipongsit39, Thipnapa Patthanathamrongkasem39, Mary Ann T Catacutan41, Irene R Felarca41, Chona S Liao41, Emma Rusmayani44, Vira Wardhana Istiantoro44, Giulia Consolandi53, Giulia Pignata53, Carlo Lavia53, Prin Rojanapongpun57, Lerprat Mangkornkanokpong86, Sunee Chansangpetch86, Jonathan C H Chan87, Bonnie N K Choy56, Jennifer W H Shum56, Hlaing May Than88, Khin Thida Oo69,70, Aye Thi Han69,70, Victor H Yong2, Xiao-Yu Ng2, Shuang Ru Goh2, Yaan Fun Chong2, Martin L Hibberd1, Mark Seielstad89, Eileen Png1, Sarah J Dunstan90,91, Nguyen Van Vinh Chau92, Jinxin Bei93,94, Yi Xin Zeng93,94,95, Abhilasha Karkey96, Buddha Basnyat96, Francesca Pasutto97, Daniela Paoli98, Paolo Frezzotti99, Jie Jin Wang100, Paul Mitchell100, John H Fingert101,102, R Rand Allingham2,103, Michael A Hauser2,103,104, Soon Thye Lim105, Soo Hong Chew106, Richard P Ebstein107, Anavaj Sakuntabhai108,109, Kyu Hyung Park110, Jeeyun Ahn111, Greet Boland112, Harm Snippe112, Richard Stead73, Raquel Quino71, Su Nyunt Zaw69,70, Urszula Lukasik18, Rohit Shetty46, Mimiwati Zahari67,68, Hyoung Won Bae61, Nay Lin Oo58, Toshiaki Kubota60, Anita Manassakorn57, Wing Lau Ho86, Laura Dallorto53, Young Hoon Hwang52, Christine A Kiire51, Masako Kuroda48, Zeiras Eka Djamal44, Jovell Ian M Peregrino41, Arkasubhra Ghosh46,113, Jin Wook Jeoung43, Tung S Hoan40, Nuttamon Srisamran39, Thayanithi Sandragasu36, Saw Htoo Set35, Vi Huyen Doan30, Shomi S Bhattacharya21, Ching-Lin Ho2, Donald T Tan2, Ramanjit Sihota29, Seng-Chee Loon27, Kazuhiko Mori16, Shigeru Kinoshita16, Anneke I den Hollander26,83, Raheel Qamar24,114, Ya-Xing Wang115, Yik Y Teo1,116,115,116,117,118,119, E-Shyong Tai116,120, Curt Hartleben-Matkin121, David Lozano-Giral122, Seang Mei Saw2,116, Ching-Yu Cheng2,27, Juan C Zenteno122,123, Chi Pui Pang11, Huong T T Bui23, Owen Hee12, Jamie E Craig31, Deepak P Edward28,82, Michiko Yonahara13, Jamil Miguel Neto78, Maria L Guevara-Fujita81, Liang Xu115, Robert Ritch47, Ahmad Tajudin Liza-Sharmini15, Tien Y Wong2, Saleh Al-Obeidan8, Nhu Hon Do4, Periasamy Sundaresan10, Clement C Tham11, Paul J Foster19,20,21, Lingam Vijaya2,7, Kei Tashiro6, Eranga N Vithana2, Ningli Wang5,115, Tin Aung2,27.
Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.Entities:
Mesh：
Year: 2016 PMID： 27064256 DOI： 10.1038/ng.3540
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330