Michael A Hauser1,2,3,4, R Rand Allingham2,3,4, Tin Aung3,4,5,6, Carly J Van Der Heide7, Kent D Taylor8,9, Jerome I Rotter8, Shih-Hsiu J Wang10, Pieter W M Bonnemaijer11,12,13, Susan E Williams14, Sadiq M Abdullahi15, Khaled K Abu-Amero16, Michael G Anderson7, Stephen Akafo17, Mahmoud B Alhassan15, Ifeoma Asimadu18, Radha Ayyagari19, Saydou Bakayoko20,21, Prisca Biangoup Nyamsi22, Donald W Bowden23, William C Bromley24, Donald L Budenz25, Trevor R Carmichael14, Pratap Challa2, Yii-Der Ida Chen8,9, Chimdi M Chuka-Okosa26, Jessica N Cooke Bailey27,28, Vital Paulino Costa29, Dianne A Cruz30, Harvey DuBiner31, John F Ervin32, Robert M Feldman33, Miles Flamme-Wiese7, Douglas E Gaasterland34, Sarah J Garnai35, Christopher A Girkin36, Nouhoum Guirou20,21, Xiuqing Guo8, Jonathan L Haines27,28, Christopher J Hammond37, Leon Herndon2, Thomas J Hoffmann38,39, Christine M Hulette10, Abba Hydara40, Robert P Igo27, Eric Jorgenson41, Joyce Kabwe42, Ngoy Janvier Kilangalanga42, Nkiru Kizor-Akaraiwe18,43, Rachel W Kuchtey44, Hasnaa Lamari45, Zheng Li46, Jeffrey M Liebmann47, Yutao Liu48,49,50, Ruth J F Loos51,52, Monica B Melo53, Sayoko E Moroi35, Joseph M Msosa54, Robert F Mullins7, Girish Nadkarni51,55, Abdoulaye Napo20,21, Maggie C Y Ng23, Hugo Freire Nunes53, Ebenezer Obeng-Nyarkoh24, Anthony Okeke56, Suhanya Okeke18,43, Olusegun Olaniyi15, Olusola Olawoye57, Mariana Borges Oliveira53, Louise R Pasquale58,59, Rodolfo A Perez-Grossmann60, Margaret A Pericak-Vance61, Xue Qin62, Michele Ramsay63, Serge Resnikoff64,65, Julia E Richards35,66, Rui Barroso Schimiti67, Kar Seng Sim46, William E Sponsel68,69, Paulo Vinicius Svidnicki53, Alberta A H J Thiadens11,13, Nkechinyere J Uche26,43, Cornelia M van Duijn11,70, José Paulo Cabral de Vasconcellos29, Janey L Wiggs71,72, Linda M Zangwill19, Neil Risch38,39,41, Dan Milea3,4,5, Adeyinka Ashaye57, Caroline C W Klaver11,13,73, Robert N Weinreb19, Allison E Ashley Koch1, John H Fingert7, Chiea Chuen Khor3,46. 1. Department of Medicine, Duke University, Durham, North Carolina. 2. Department of Ophthalmology, Duke University, Durham, North Carolina. 3. Singapore Eye Research Institute, Singapore. 4. Duke-NUS Medical School, Signapore. 5. Singapore National Eye Center, Singapore. 6. Department of Ophthalmology, Young Loo Lin School of Medicine, Singapore. 7. Carver College of Medicine, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City. 8. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California. 9. Department of Pediatrics, Harbor-University of California, Los Angeles Medical Center, Torrance. 10. Department of Pathology, Duke University, Durham, North Carolina. 11. Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. 12. Rotterdam Eye Hospital, Rotterdam, the Netherlands. 13. Department of Ophthalmology, Erasmus MC, Rotterdam, the Netherlands. 14. Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa. 15. National Eye Centre, Kaduna, Nigeria. 16. Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 17. Unit of Ophthalmology, Department of Surgery, University of Ghana Medical School, Accra, Ghana. 18. Department of Ophthalmology, ESUT Teaching Hospital Parklane, Enugu, Nigeria. 19. Shiley Eye Institute, Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla. 20. Institut d'Ophtalmologie Tropicale de l'Afrique, Bamako, Mali. 21. Université des Sciences des Techniques et des Technologies de Bamako, Bamako, Mali. 22. Service Spécialisé d'ophtalmologie, Hôpital Militaire de Région No1 de Yaoundé, Yaoundé, Cameroun. 23. Center for Diabetes Research, Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina. 24. Center for Human Genetics, Bar Harbor, Maine. 25. Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 26. University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria. 27. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio. 28. Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio. 29. Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil. 30. Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina. 31. Clayton Eye Care Center Management Inc, Marrow, Georgia. 32. Kathleen Price Bryan Brain Bank and Biorepository, Department of Neurology, Duke University, Durham, North Carolina. 33. McGovern Medical School, Ruiz Department of Ophthalmology & Visual Science, The University of Texas Health Science Center at Houston, Houston. 34. The Emmes Corporation, Rockville, Maryland. 35. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor. 36. Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham. 37. Section of Academic Ophthalmology, School of Life Course Sciences, FoLSM, King's College London, London, United Kingdom. 38. Department of Epidemiology and Biostatistics, University of California at San Francisco. 39. Institute for Human Genetics, University of California at San Francisco. 40. Sheikh Zayed Regional Eye Care Centre, Kanifing, The Gambia. 41. Division of Research, Kaiser Permanente Northern California, Oakland. 42. Department of Ophthalmology, St Joseph Hospital, Kinshasa, Limete, Democratic Republic of the Congo. 43. The Eye Specialists Hospital, Enugu, Nigeria. 44. Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. 45. Clinique Spécialisée en Ophtalmologie Mohammedia, Mohammedia, Morocco. 46. Genome Institute of Singapore, Singapore. 47. Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center, New York, New York. 48. Cellular Biology and Anatomy, Augusta University, Augusta, Georgia. 49. James & Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia. 50. Center for Biotechnology & Genomic Medicine, Augusta University, Augusta, Georgia. 51. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. 52. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York. 53. Center for Molecular Biology and Genetic Engineering, University of Campinas, Campinas, Brazil. 54. Lions Sight-First Eye Hospital, Kamuzu Central Hospital, Lilongwe, Malawi. 55. Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. 56. Nigerian Navy Reference Hospital, Ojo, Lagos, Nigeria. 57. Department of Ophthalmology, University of Ibadan, Ibadan, Nigeria. 58. Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York. 59. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 60. Instituto de Glaucoma y Catarata, Lima, Peru. 61. John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida. 62. Duke Molecular Physiology Institute, Duke University, Durham, North Carolina. 63. Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. 64. Brien Holden Vision Institute, Sydney, Australia. 65. School of Optometry and Vision Science, University of New South Wales, Sydney, Australia. 66. Department of Epidemiology, University of Michigan, Ann Arbor. 67. Hoftalon Hospital, Londrina, Brazil. 68. San Antonio Eye Health, San Antonio, Texas. 69. Eyes of Africa, Child Legacy International (CLI) Hospital, Msundwe, Malawi. 70. Nuffield Department of Public Health, University of Oxford, Oxford, United Kingdom. 71. Harvard University Medical School, Boston, Massachusetts. 72. Massachusetts Eye and Ear Hospital, Boston. 73. Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands.
Abstract
Importance: Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders. Objectives: To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma. Design, Settings, and Participants: A 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 unaffected individuals using multicenter clinic- and population-based participant recruitment approaches. Study participants were recruited from Ghana, Nigeria, South Africa, the United States, Tanzania, Britain, Cameroon, Saudi Arabia, Brazil, the Democratic Republic of the Congo, Morocco, Peru, and Mali from 2003 to 2018. Individuals with primary open-angle glaucoma had open iridocorneal angles and displayed glaucomatous optic neuropathy with visual field defects. Elevated intraocular pressure was not included in the case definition. Control individuals had no elevated intraocular pressure and no signs of glaucoma. Exposures: Genetic variants associated with primary open-angle glaucoma. Main Outcomes and Measures: Presence of primary open-angle glaucoma. Genome-wide significance was defined as P < 5 × 10-8 in the discovery stage and in the meta-analysis of combined discovery and validation data. Results: A total of 2320 individuals with primary open-angle glaucoma (mean [interquartile range] age, 64.6 [56-74] years; 1055 [45.5%] women) and 2121 individuals without primary open-angle glaucoma (mean [interquartile range] age, 63.4 [55-71] years; 1025 [48.3%] women) were included in the discovery GWAS. The GWAS discovery meta-analysis demonstrated association of variants at amyloid-β A4 precursor protein-binding family B member 2 (APBB2; chromosome 4, rs59892895T>C) with primary open-angle glaucoma (odds ratio [OR], 1.32 [95% CI, 1.20-1.46]; P = 2 × 10-8). The association was validated in an analysis of an additional 6937 affected individuals and 14 917 unaffected individuals (OR, 1.15 [95% CI, 1.09-1.21]; P < .001). Each copy of the rs59892895*C risk allele was associated with increased risk of primary open-angle glaucoma when all data were included in a meta-analysis (OR, 1.19 [95% CI, 1.14-1.25]; P = 4 × 10-13). The rs59892895*C risk allele was present at appreciable frequency only in African ancestry populations. In contrast, the rs59892895*C risk allele had a frequency of less than 0.1% in individuals of European or Asian ancestry. Conclusions and Relevance: In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry. If validated in additional populations this finding may have implications for risk assessment and therapeutic strategies.
Importance: Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders. Objectives: To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma. Design, Settings, and Participants: A 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 unaffected individuals using multicenter clinic- and population-based participant recruitment approaches. Study participants were recruited from Ghana, Nigeria, South Africa, the United States, Tanzania, Britain, Cameroon, Saudi Arabia, Brazil, the Democratic Republic of the Congo, Morocco, Peru, and Mali from 2003 to 2018. Individuals with primary open-angle glaucoma had open iridocorneal angles and displayed glaucomatous optic neuropathy with visual field defects. Elevated intraocular pressure was not included in the case definition. Control individuals had no elevated intraocular pressure and no signs of glaucoma. Exposures: Genetic variants associated with primary open-angle glaucoma. Main Outcomes and Measures: Presence of primary open-angle glaucoma. Genome-wide significance was defined as P < 5 × 10-8 in the discovery stage and in the meta-analysis of combined discovery and validation data. Results: A total of 2320 individuals with primary open-angle glaucoma (mean [interquartile range] age, 64.6 [56-74] years; 1055 [45.5%] women) and 2121 individuals without primary open-angle glaucoma (mean [interquartile range] age, 63.4 [55-71] years; 1025 [48.3%] women) were included in the discovery GWAS. The GWAS discovery meta-analysis demonstrated association of variants at amyloid-β A4 precursor protein-binding family B member 2 (APBB2; chromosome 4, rs59892895T>C) with primary open-angle glaucoma (odds ratio [OR], 1.32 [95% CI, 1.20-1.46]; P = 2 × 10-8). The association was validated in an analysis of an additional 6937 affected individuals and 14 917 unaffected individuals (OR, 1.15 [95% CI, 1.09-1.21]; P < .001). Each copy of the rs59892895*C risk allele was associated with increased risk of primary open-angle glaucoma when all data were included in a meta-analysis (OR, 1.19 [95% CI, 1.14-1.25]; P = 4 × 10-13). The rs59892895*C risk allele was present at appreciable frequency only in African ancestry populations. In contrast, the rs59892895*C risk allele had a frequency of less than 0.1% in individuals of European or Asian ancestry. Conclusions and Relevance: In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry. If validated in additional populations this finding may have implications for risk assessment and therapeutic strategies.
Authors: Luis Fernández-Vega Cueto; Tin Aung; Mineo Ozaki; Mei Chin Lee; Ursula Schlötzer-Schrehardt; Gudmar Thorleifsson; Takanori Mizoguchi; Robert P Igo; Aravind Haripriya; Susan E Williams; Yury S Astakhov; Andrew C Orr; Kathryn P Burdon; Satoko Nakano; Kazuhiko Mori; Khaled Abu-Amero; Michael Hauser; Zheng Li; Gopalakrishnan Prakadeeswari; Jessica N Cooke Bailey; Alina Popa Cherecheanu; Jae H Kang; Sarah Nelson; Ken Hayashi; Shin-Ichi Manabe; Shigeyasu Kazama; Tomasz Zarnowski; Kenji Inoue; Murat Irkec; Miguel Coca-Prados; Kazuhisa Sugiyama; Irma Järvelä; Patricio Schlottmann; S Fabian Lerner; Hasnaa Lamari; Yildirim Nilgün; Mukharram Bikbov; Ki Ho Park; Soon Cheol Cha; Kenji Yamashiro; Juan C Zenteno; Jost B Jonas; Rajesh S Kumar; Shamira A Perera; Anita S Y Chan; Nino Kobakhidze; Ronnie George; Lingam Vijaya; Tan Do; Deepak P Edward; Lourdes de Juan Marcos; Mohammad Pakravan; Sasan Moghimi; Ryuichi Ideta; Daniella Bach-Holm; Per Kappelgaard; Barbara Wirostko; Samuel Thomas; Daniel Gaston; Karen Bedard; Wenda L Greer; Zhenglin Yang; Xueyi Chen; Lulin Huang; Jinghong Sang; Hongyan Jia; Liyun Jia; Chunyan Qiao; Hui Zhang; Xuyang Liu; Bowen Zhao; Ya-Xing Wang; Liang Xu; Stéphanie Leruez; Pascal Reynier; George Chichua; Sergo Tabagari; Steffen Uebe; Matthias Zenkel; Daniel Berner; Georg Mossböck; Nicole Weisschuh; Ursula Hoja; Ulrich-Christoph Welge-Luessen; Christian Mardin; Panayiota Founti; Anthi Chatzikyriakidou; Theofanis Pappas; Eleftherios Anastasopoulos; Alexandros Lambropoulos; Arkasubhra Ghosh; Rohit Shetty; Natalia Porporato; Vijayan Saravanan; Rengaraj Venkatesh; Chandrashekaran Shivkumar; Narendran Kalpana; Sripriya Sarangapani; Mozhgan R Kanavi; Afsaneh Naderi Beni; Shahin Yazdani; Alireza Lashay; Homa Naderifar; Nassim Khatibi; Antonio Fea; Carlo Lavia; Laura Dallorto; Teresa Rolle; Paolo Frezzotti; Daniela Paoli; Erika Salvi; Paolo Manunta; Yosai Mori; Kazunori Miyata; Tomomi Higashide; Etsuo Chihara; Satoshi Ishiko; Akitoshi Yoshida; Masahide Yanagi; Yoshiaki Kiuchi; Tsutomu Ohashi; Toshiya Sakurai; Takako Sugimoto; Hideki Chuman; Makoto Aihara; Masaru Inatani; Masahiro Miyake; Norimoto Gotoh; Fumihiko Matsuda; Nagahisa Yoshimura; Yoko Ikeda; Morio Ueno; Chie Sotozono; Jin Wook Jeoung; Min Sagong; Kyu Hyung Park; Jeeyun Ahn; Marisa Cruz-Aguilar; Sidi M Ezzouhairi; Abderrahman Rafei; Yaan Fun Chong; Xiao Yu Ng; Shuang Ru Goh; Yueming Chen; Victor H K Yong; Muhammad Imran Khan; Olusola O Olawoye; Adeyinka O Ashaye; Idakwo Ugbede; Adeola Onakoya; Nkiru Kizor-Akaraiwe; Chaiwat Teekhasaenee; Yanin Suwan; Wasu Supakontanasan; Suhanya Okeke; Nkechi J Uche; Ifeoma Asimadu; Humaira Ayub; Farah Akhtar; Ewa Kosior-Jarecka; Urszula Lukasik; Ignacio Lischinsky; Vania Castro; Rodolfo Perez Grossmann; Gordana Sunaric Megevand; Sylvain Roy; Edward Dervan; Eoin Silke; Aparna Rao; Priti Sahay; Pablo Fornero; Osvaldo Cuello; Delia Sivori; Tamara Zompa; Richard A Mills; Emmanuelle Souzeau; Paul Mitchell; Jie Jin Wang; Alex W Hewitt; Michael Coote; Jonathan G Crowston; Sergei Y Astakhov; Eugeny L Akopov; Anton Emelyanov; Vera Vysochinskaya; Gyulli Kazakbaeva; Rinat Fayzrakhmanov; Saleh A Al-Obeidan; Ohoud Owaidhah; Leyla Ali Aljasim; Balram Chowbay; Jia Nee Foo; Raphael Q Soh; Kar Seng Sim; Zhicheng Xie; Augustine W O Cheong; Shi Qi Mok; Hui Meng Soo; Xiao Yin Chen; Su Qin Peh; Khai Koon Heng; Rahat Husain; Su-Ling Ho; Axel M Hillmer; Ching-Yu Cheng; Francisco A Escudero-Domínguez; Rogelio González-Sarmiento; Frederico Martinon-Torres; Antonio Salas; Kessara Pathanapitoon; Linda Hansapinyo; Boonsong Wanichwecharugruang; Naris Kitnarong; Anavaj Sakuntabhai; Hip X Nguyn; Giang T T Nguyn; Trình V Nguyn; Werner Zenz; Alexander Binder; Daniela S Klobassa; Martin L Hibberd; Sonia Davila; Stefan Herms; Markus M Nöthen; Susanne Moebus; Robyn M Rautenbach; Ari Ziskind; Trevor R Carmichael; Michele Ramsay; Lydia Álvarez; Montserrat García; Héctor González-Iglesias; Pedro P Rodríguez-Calvo; Çilingir Oguz; Nevbahar Tamcelik; Eray Atalay; Bilge Batu; Dilek Aktas; Burcu Kasım; M Roy Wilson; Anne L Coleman; Yutao Liu; Pratap Challa; Leon Herndon; Rachel W Kuchtey; John Kuchtey; Karen Curtin; Craig J Chaya; Alan Crandall; Linda M Zangwill; Tien Yin Wong; Masakazu Nakano; Shigeru Kinoshita; Anneke I den Hollander; Eija Vesti; John H Fingert; Richard K Lee; Arthur J Sit; Bradford J Shingleton; Ningli Wang; Daniele Cusi; Raheel Qamar; Peter Kraft; Margaret A Pericak-Vance; Soumya Raychaudhuri; Steffen Heegaard; Tero Kivelä; André Reis; Friedrich E Kruse; Robert N Weinreb; Louis R Pasquale; Jonathan L Haines; Unnur Thorsteinsdottir; Fridbert Jonasson; R Rand Allingham; Dan Milea; Robert Ritch; Toshiaki Kubota; Kei Tashiro; Eranga N Vithana; Shazia Micheal; Fotis Topouzis; Jamie E Craig; Michael Dubina; Periasamy Sundaresan; Kari Stefansson; Janey L Wiggs; Francesca Pasutto; Chiea Chuen Khor Journal: Nat Genet Date: 2017-05-29 Impact factor: 38.330
Authors: Yang Chang; Giuseppina Tesco; William J Jeong; Loren Lindsley; Elizabeth A Eckman; Christopher B Eckman; Rudolph E Tanzi; Suzanne Y Guénette Journal: J Biol Chem Date: 2003-10-03 Impact factor: 5.157
Authors: Bryan Howie; Christian Fuchsberger; Matthew Stephens; Jonathan Marchini; Gonçalo R Abecasis Journal: Nat Genet Date: 2012-07-22 Impact factor: 38.330
Authors: Zheng Li; R Rand Allingham; Masakazu Nakano; Liyun Jia; Yuhong Chen; Yoko Ikeda; Baskaran Mani; Li-Jia Chen; Changwon Kee; David F Garway-Heath; Sarangapani Sripriya; Nobuo Fuse; Khaled K Abu-Amero; Chukai Huang; Prasanthi Namburi; Kathryn Burdon; Shamira A Perera; Puya Gharahkhani; Ying Lin; Morio Ueno; Mineo Ozaki; Takanori Mizoguchi; Subbiah Ramasamy Krishnadas; Essam A Osman; Mei Chin Lee; Anita S Y Chan; Liza-Sharmini A Tajudin; Tan Do; Aurelien Goncalves; Pascal Reynier; Hong Zhang; Rupert Bourne; David Goh; David Broadway; Rahat Husain; Anil K Negi; Daniel H Su; Ching-Lin Ho; Augusto Azuara Blanco; Christopher K S Leung; Tina T Wong; Azhany Yakub; Yutao Liu; Monisha E Nongpiur; Jong Chul Han; Do Nhu Hon; Balekudaru Shantha; Bowen Zhao; Jinghong Sang; NiHong Zhang; Ryuichi Sato; Kengo Yoshii; Songhomita Panda-Jonas; Allison E Ashley Koch; Leon W Herndon; Sayoko E Moroi; Pratap Challa; Jia Nee Foo; Jin-Xin Bei; Yi-Xin Zeng; Cameron P Simmons; Tran Nguyen Bich Chau; Philomenadin Ferdinamarie Sharmila; Merwyn Chew; Blanche Lim; Pansy O S Tam; Elaine Chua; Xiao Yu Ng; Victor H K Yong; Yaan Fun Chong; Wee Yang Meah; Saravanan Vijayan; Sohn Seongsoo; Wang Xu; Yik Ying Teo; Jessica N Cooke Bailey; Jae H Kang; Jonathan L Haines; Ching Yu Cheng; Seang-Mei Saw; E-Shyong Tai; Julia E Richards; Robert Ritch; Douglas E Gaasterland; Louis R Pasquale; Jianjun Liu; Jost B Jonas; Dan Milea; Ronnie George; Saleh A Al-Obeidan; Kazuhiko Mori; Stuart Macgregor; Alex W Hewitt; Christopher A Girkin; Mingzhi Zhang; Periasamy Sundaresan; Lingam Vijaya; David A Mackey; Tien Yin Wong; Jamie E Craig; Xinghuai Sun; Shigeru Kinoshita; Janey L Wiggs; Chiea-Chuen Khor; Zhenglin Yang; Chi Pui Pang; Ningli Wang; Michael A Hauser; Kei Tashiro; Tin Aung; Eranga N Vithana Journal: Hum Mol Genet Date: 2015-04-10 Impact factor: 6.150
Authors: Jessica N Cooke Bailey; Stephanie J Loomis; Jae H Kang; R Rand Allingham; Puya Gharahkhani; Chiea Chuen Khor; Kathryn P Burdon; Hugues Aschard; Daniel I Chasman; Robert P Igo; Pirro G Hysi; Craig A Glastonbury; Allison Ashley-Koch; Murray Brilliant; Andrew A Brown; Donald L Budenz; Alfonso Buil; Ching-Yu Cheng; Hyon Choi; William G Christen; Gary Curhan; Immaculata De Vivo; John H Fingert; Paul J Foster; Charles Fuchs; Douglas Gaasterland; Terry Gaasterland; Alex W Hewitt; Frank Hu; David J Hunter; Anthony P Khawaja; Richard K Lee; Zheng Li; Paul R Lichter; David A Mackey; Peter McGuffin; Paul Mitchell; Sayoko E Moroi; Shamira A Perera; Keating W Pepper; Qibin Qi; Tony Realini; Julia E Richards; Paul M Ridker; Eric Rimm; Robert Ritch; Marylyn Ritchie; Joel S Schuman; William K Scott; Kuldev Singh; Arthur J Sit; Yeunjoo E Song; Rulla M Tamimi; Fotis Topouzis; Ananth C Viswanathan; Shefali Setia Verma; Douglas Vollrath; Jie Jin Wang; Nicole Weisschuh; Bernd Wissinger; Gadi Wollstein; Tien Y Wong; Brian L Yaspan; Donald J Zack; Kang Zhang; Epic-Norfolk Eye Study; Robert N Weinreb; Margaret A Pericak-Vance; Kerrin Small; Christopher J Hammond; Tin Aung; Yutao Liu; Eranga N Vithana; Stuart MacGregor; Jamie E Craig; Peter Kraft; Gareth Howell; Michael A Hauser; Louis R Pasquale; Jonathan L Haines; Janey L Wiggs Journal: Nat Genet Date: 2016-01-11 Impact factor: 38.330
Authors: Henriët Springelkamp; René Höhn; Aniket Mishra; Pirro G Hysi; Chiea-Chuen Khor; Stephanie J Loomis; Jessica N Cooke Bailey; Jane Gibson; Gudmar Thorleifsson; Sarah F Janssen; Xiaoyan Luo; Wishal D Ramdas; Eranga Vithana; Monisha E Nongpiur; Grant W Montgomery; Liang Xu; Jenny E Mountain; Puya Gharahkhani; Yi Lu; Najaf Amin; Lennart C Karssen; Kar-Seng Sim; Elisabeth M van Leeuwen; Adriana I Iglesias; Virginie J M Verhoeven; Michael A Hauser; Seng-Chee Loon; Dominiek D G Despriet; Abhishek Nag; Cristina Venturini; Paul G Sanfilippo; Arne Schillert; Jae H Kang; John Landers; Fridbert Jonasson; Angela J Cree; Leonieke M E van Koolwijk; Fernando Rivadeneira; Emmanuelle Souzeau; Vesteinn Jonsson; Geeta Menon; Robert N Weinreb; Paulus T V M de Jong; Ben A Oostra; André G Uitterlinden; Albert Hofman; Sarah Ennis; Unnur Thorsteinsdottir; Kathryn P Burdon; Timothy D Spector; Alireza Mirshahi; Seang-Mei Saw; Johannes R Vingerling; Yik-Ying Teo; Jonathan L Haines; Roger C W Wolfs; Hans G Lemij; E-Shyong Tai; Nomdo M Jansonius; Jost B Jonas; Ching-Yu Cheng; Tin Aung; Ananth C Viswanathan; Caroline C W Klaver; Jamie E Craig; Stuart Macgregor; David A Mackey; Andrew J Lotery; Kari Stefansson; Arthur A B Bergen; Terri L Young; Janey L Wiggs; Norbert Pfeiffer; Tien-Yin Wong; Louis R Pasquale; Alex W Hewitt; Cornelia M van Duijn; Christopher J Hammond Journal: Nat Commun Date: 2014-09-22 Impact factor: 14.919
Authors: Cari L Nealon; Christopher W Halladay; Tyler G Kinzy; Piana Simpson; Rachael L Canania; Scott A Anthony; David P Roncone; Lea R Sawicki Rogers; Jenna N Leber; Jacquelyn M Dougherty; Jack M Sullivan; Wen-Chih Wu; Paul B Greenberg; Sudha K Iyengar; Dana C Crawford; Neal S Peachey; Jessica N Cooke Bailey Journal: Ophthalmic Epidemiol Date: 2021-11-25
Authors: Nicholas G Tolman; Revathi Balasubramanian; Danilo G Macalinao; Alison L Kearney; Katharine H MacNicoll; Christa L Montgomery; Wilhelmine N de Vries; Ian J Jackson; Sally H Cross; Krishnakumar Kizhatil; K Saidas Nair; Simon W M John Journal: Dis Model Mech Date: 2021-02-19 Impact factor: 5.758
Authors: Kimberly P Hreha; Steve R Fisher; Timothy A Reistetter; Kenneth Ottenbacher; Allen Haas; Chih-Ying Li; Joshua R Ehrlich; Diane B Whitaker; Heather E Whitson Journal: BMC Health Serv Res Date: 2020-07-08 Impact factor: 2.655
Authors: Sally L Baxter; William T Keenan; Argus J Athanas; James A Proudfoot; Linda M Zangwill; Radha Ayyagari; Jeffrey M Liebmann; Christopher A Girkin; Ardem Patapoutian; Robert N Weinreb Journal: Sci Rep Date: 2020-11-04 Impact factor: 4.379