| Literature DB >> 22922875 |
Eranga N Vithana1,2, Chiea-Chuen Khor1,2,3,4,5,6, Chunyan Qiao7, Ningli Wang7, Tin Aung1,2, Monisha E Nongpiur1,2, Ronnie George8, Li-Jia Chen9, Tan Do10, Khaled Abu-Amero11,12, Chor Kai Huang13, Sancy Low14, Liza-Sharmini A Tajudin15, Shamira A Perera1, Ching-Yu Cheng1,2,6, Liang Xu16, Hongyan Jia7, Ching-Lin Ho1, Kar Seng Sim4, Ren-Yi Wu1,17, Clement C Y Tham9, Paul T K Chew2, Daniel H Su1, Francis T Oen1, Sripriya Sarangapani8, Nagaswamy Soumittra8, Essam A Osman11, Hon-Tym Wong18, Guangxian Tang19, Sujie Fan20, Hailin Meng21, Dao T L Huong10, Hua Wang7, Bo Feng7, Mani Baskaran1, Balekudaru Shantha8, Vedam L Ramprasad8, Govindasamy Kumaramanickavel8, Sudha K Iyengar22, Alicia C How1, Kelvin Y Lee1, Theru A Sivakumaran22, Victor H K Yong1, Serena M L Ting1, Yang Li15, Ya-Xing Wang16, Wan-Ting Tay1, Xueling Sim23, Raghavan Lavanya1, Belinda K Cornes1, Ying-Feng Zheng1,2, Tina T Wong1, Seng-Chee Loon2, Vernon K Y Yong18, Naushin Waseem14, Azhany Yaakub15, Kee-Seng Chia6, R Rand Allingham24, Michael A Hauser24, Dennis S C Lam9, Martin L Hibberd3,6, Shomi S Bhattacharya14, Mingzhi Zhang13, Yik Ying Teo4,6,23, Donald T Tan1,2, Jost B Jonas25, E-Shyong Tai6,26,27, Seang-Mei Saw1,6, Do Nhu Hon10, Saleh A Al-Obeidan11, Jianjun Liu4,6, Tran Nguyen Bich Chau28, Cameron P Simmons28,29, Jin-Xin Bei30,31, Yi-Xin Zeng30,31,32, Paul J Foster14, Lingam Vijaya8, Tien-Yin Wong1,2,6, Chi-Pui Pang9.
Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22922875 PMCID： PMC4333205 DOI： 10.1038/ng.2390
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330