Literature DB >> 27010932

Chemical structures of constituents from the whole plant of Bacopa monniera.

Tomoe Ohta1, Seikou Nakamura1, Souichi Nakashima1,2, Yoshimi Oda1,2, Takahiro Matsumoto1, Masashi Fukaya1, Mamiko Yano1, Masayuki Yoshikawa1, Hisashi Matsuda3.   

Abstract

Two new dammarane-type triterpene oligoglycosides, bacomosaponins A and B, and three new phenylethanoid glycosides, bacomosides A, B1, and B2, were isolated from the whole plant of Bacopa monniera Wettst. The chemical structures of the new constituents were characterized on the basis of chemical and physicochemical evidence. In the present study, bacomosaponins A and B with acyl groups were obtained from the whole plant of B. monniera. This is the first report of acylated dammarane-type triterpene oligoglycosides isolated from B. monniera. In addition, dammarane-type triterpene saponins significantly inhibited the aggregation of 42-mer amyloid β-protein.

Entities:  

Keywords:  Ayurvedic traditional medicine; Aβ42 aggregation; Bacomosaponin; Bacomoside; Bacopa monniera

Mesh：

Substances：

Year:  2016        PMID： 27010932     DOI： 10.1007/s11418-016-0986-0

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  20 in total

1.  Bacopasaponins E and F: two jujubogenin bisdesmosides from Bacopa monniera.

Authors:  S B Mahato; S Garai; A K Chakravarty
Journal:  Phytochemistry       Date:  2000-03       Impact factor: 4.072

2.  Bacopa monniera extract reduces amyloid levels in PSAPP mice.

Authors:  Leigh A Holcomb; Muralikrishnan Dhanasekaran; Angie R Hitt; Keith A Young; Mark Riggs; Bala V Manyam
Journal:  J Alzheimers Dis       Date:  2006-08       Impact factor: 4.472

3.  Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models.

Authors:  Yun Zhou; Yun-Heng Shen; Chuan Zhang; Juan Su; Run-Hui Liu; Wei-Dong Zhang
Journal:  J Nat Prod       Date:  2007-03-08       Impact factor: 4.050

4.  Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture.

Authors:  Nanteetip Limpeanchob; Somkiet Jaipan; Saisunee Rattanakaruna; Watoo Phrompittayarat; Kornkanok Ingkaninan
Journal:  J Ethnopharmacol       Date:  2008-08-05       Impact factor: 4.360

5.  Clinical trial on Brahmi. I.

Authors:  G D Mukherjee; C D Dey
Journal:  J Exp Med Sci       Date:  1966 Jun-Sep

6.  Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.

Authors:  Masayuki Yoshikawa; Toshio Morikawa; Hisanori Kobayashi; Akihiko Nakamura; Koudai Matsuhira; Seikou Nakamura; Hisashi Matsuda
Journal:  Chem Pharm Bull (Tokyo)       Date:  2007-03       Impact factor: 1.645

7.  Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.

Authors:  Seikou Nakamura; Souichi Nakashima; Yoshimi Oda; Nami Yokota; Katsuyoshi Fujimoto; Takahiro Matsumoto; Tomoe Ohta; Keiko Ogawa; Sayuri Maeda; Shino Nishida; Hisashi Matsuda; Masayuki Yoshikawa
Journal:  Bioorg Med Chem       Date:  2013-01-16       Impact factor: 3.641

8.  Bacoside A3--a triterpenoid saponin from Bacopa monniera.

Authors:  S Rastogi; R Pal
Journal:  Phytochemistry       Date:  1994-05       Impact factor: 4.072

9.  Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

Authors:  Yusaku Miyamae; Manami Kurisu; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori
Journal:  Bioorg Med Chem       Date:  2012-08-12       Impact factor: 3.641

10.  A rare glutamine derivative from the flower buds of daylily.

Authors:  Takahiro Matsumoto; Seikou Nakamura; Tomoe Ohta; Katsuyoshi Fujimoto; Masayuki Yoshikawa; Keiko Ogawa; Hisashi Matsuda
Journal:  Org Lett       Date:  2014-05-16       Impact factor: 6.005
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  3 in total

1.  BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells.

Authors:  Mamiko Yano; Souichi Nakashima; Yoshimi Oda; Seikou Nakamura; Hisashi Matsuda
Journal:  J Nat Med       Date:  2019-11-09       Impact factor: 2.343

Review 2.  Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance.

Authors:  Tanya Biswas; Upendra N Dwivedi
Journal:  Protoplasma       Date:  2019-07-11       Impact factor: 3.356

3.  Discovery of Lipid Peroxidation Inhibitors from Bacopa Species Prioritized through Multivariate Data Analysis and Multi-Informative Molecular Networking.

Authors:  Tongchai Saesong; Pierre-Marie Allard; Emerson Ferreira Queiroz; Laurence Marcourt; Nitra Nuengchamnong; Prapapan Temkitthawon; Nantaka Khorana; Jean-Luc Wolfender; Kornkanok Ingkaninan
Journal:  Molecules       Date:  2019-08-17       Impact factor: 4.411
  3 in total

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