Literature DB >> 23376010

Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.

Seikou Nakamura1, Souichi Nakashima, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Tomoe Ohta, Keiko Ogawa, Sayuri Maeda, Shino Nishida, Hisashi Matsuda, Masayuki Yoshikawa.   

Abstract

A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known carbazole alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23376010     DOI： 10.1016/j.bmc.2013.01.012

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  Chemical structures of constituents from the whole plant of Bacopa monniera.

Authors:  Tomoe Ohta; Seikou Nakamura; Souichi Nakashima; Yoshimi Oda; Takahiro Matsumoto; Masashi Fukaya; Mamiko Yano; Masayuki Yoshikawa; Hisashi Matsuda
Journal:  J Nat Med       Date:  2016-03-24       Impact factor: 2.343

2.  Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study.

Authors:  Fatemeh Ahmadipour; Mohamed Ibrahim Noordin; Syam Mohan; Aditya Arya; Mohammadjavad Paydar; Chung Yeng Looi; Yeap Swee Keong; Ebrahimi Nigjeh Siyamak; Somayeh Fani; Maryam Firoozi; Chung Lip Yong; Mohamed Aspollah Sukari; Behnam Kamalidehghan
Journal:  Drug Des Devel Ther       Date:  2015-02-24       Impact factor: 4.162

3.  The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism.

Authors:  Nushrat Sharmin Ani; Sudip Chakraborty; Md Moniruzzaman
Journal:  Adv Pharmacol Sci       Date:  2016-10-12

4.  Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds.

Authors:  Weicheng Wang; Yi Zhang; Souichi Nakashima; Seikou Nakamura; Tao Wang; Masayuki Yoshikawa; Hisashi Matsuda
Journal:  J Nat Med       Date:  2019-03-07       Impact factor: 2.343

5.  Inhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from Murraya koenigii (L) Spreng.

Authors:  Behnam Kamalidehghan; Soudeh Ghafouri-Fard; Elahe Motevaseli; Fatemeh Ahmadipour
Journal:  Drug Des Devel Ther       Date:  2018-05-04       Impact factor: 4.162
  5 in total

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