Literature DB >> 31707550

BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells.

Mamiko Yano1, Souichi Nakashima1, Yoshimi Oda1,2, Seikou Nakamura1, Hisashi Matsuda3.   

Abstract

Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine, N-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and N-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and N-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer's disease, because of their activity and BBB permeability.

Entities:  

Keywords:  Alkaloid; BBB; Nelumbo nucifera; Neurite outgrowth; PC-12

Mesh：

Substances：

Year:  2019        PMID： 31707550     DOI： 10.1007/s11418-019-01368-7

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  15 in total

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Journal:  J Nat Med       Date:  2016-03-24       Impact factor: 2.343

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5.  New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition.

Authors:  Yoshimi Oda; Souichi Nakashima; Seikou Nakamura; Mamiko Yano; Masanori Akiyama; Kayo Imai; Tomohito Kimura; Akiko Nakata; Miyuki Tani; Hisashi Matsuda
Journal:  J Nat Med       Date:  2016-03-02       Impact factor: 2.343

6.  γ-Lactam alkaloids from the flower buds of daylily.

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Journal:  J Nat Med       Date:  2016-02-05       Impact factor: 2.343

7.  Antioxidant and anticancer aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena.

Authors:  Chi-Ming Liu; Chiu-Li Kao; Hui-Ming Wu; Wei-Jen Li; Cheng-Tsung Huang; Hsing-Tan Li; Chung-Yi Chen
Journal:  Molecules       Date:  2014-11-03       Impact factor: 4.411

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Journal:  Molecules       Date:  2017-07-28       Impact factor: 4.411

9.  Purification and characterization of aporphine alkaloids from leaves of Nelumbo nucifera Gaertn and their effects on glucose consumption in 3T3-L1 adipocytes.

Authors:  Chengjun Ma; Jinjun Wang; Hongmei Chu; Xiaoxiao Zhang; Zhenhua Wang; Honglun Wang; Gang Li
Journal:  Int J Mol Sci       Date:  2014-02-26       Impact factor: 5.923

10.  Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity.

Authors:  Toshio Morikawa; Niichiro Kitagawa; Genzoh Tanabe; Kiyofumi Ninomiya; Shuhei Okugawa; Chiaki Motai; Iyori Kamei; Masayuki Yoshikawa; I-Jung Lee; Osamu Muraoka
Journal:  Molecules       Date:  2016-07-19       Impact factor: 4.411
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  4 in total

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Journal:  PLoS One       Date:  2020-11-02       Impact factor: 3.240

Review 2.  Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases.

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Journal:  Molecules       Date:  2021-01-30       Impact factor: 4.411

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4.  Analysis of Active Compounds Using Target Protein Cofilin-Cucurbitacins in Cytotoxic Plant Bryonia cretica.

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Journal:  Toxins (Basel)       Date:  2022-03-16       Impact factor: 4.546
  4 in total

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