Literature DB >> 26958879

K-Ras at Anionic Membranes: Orientation, Orientation…Orientation. Recent Simulations and Experiments.

ZhenLu Li1, Shufen Cao1, Matthias Buck2.   

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Year:  2016        PMID： 26958879      PMCID： PMC4788742          DOI： 10.1016/j.bpj.2016.01.020

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


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  10 in total

1.  Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.

Authors:  S Bouguet-Bonnet; M Buck
Journal:  J Mol Biol       Date:  2008-02-04       Impact factor: 5.469

2.  VMD: visual molecular dynamics.

Authors:  W Humphrey; A Dalke; K Schulten
Journal:  J Mol Graph       Date:  1996-02

3.  Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD.

Authors:  Susan K Fetics; Hugo Guterres; Bradley M Kearney; Greg Buhrman; Buyong Ma; Ruth Nussinov; Carla Mattos
Journal:  Structure       Date:  2015-02-12       Impact factor: 5.006

4.  Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Authors:  Mohammad T Mazhab-Jafari; Christopher B Marshall; Matthew J Smith; Geneviève M C Gasmi-Seabrook; Peter B Stathopulos; Fuyuhiko Inagaki; Lewis E Kay; Benjamin G Neel; Mitsuhiko Ikura
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

5.  GTP-Dependent K-Ras Dimerization.

Authors:  Serena Muratcioglu; Tanmay S Chavan; Benjamin C Freed; Hyunbum Jang; Lyuba Khavrutskii; R Natasha Freed; Marzena A Dyba; Karen Stefanisko; Sergey G Tarasov; Attila Gursoy; Ozlem Keskin; Nadya I Tarasova; Vadim Gaponenko; Ruth Nussinov
Journal:  Structure       Date:  2015-06-04       Impact factor: 5.006

6.  Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer.

Authors:  Alemayehu A Gorfe; Michael Hanzal-Bayer; Daniel Abankwa; John F Hancock; J Andrew McCammon
Journal:  J Med Chem       Date:  2007-01-31       Impact factor: 7.446

7.  Ras membrane orientation and nanodomain localization generate isoform diversity.

Authors:  Daniel Abankwa; Alemayehu A Gorfe; Kerry Inder; John F Hancock
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-04       Impact factor: 11.205

8.  Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.

Authors:  Priyanka Prakash; Yong Zhou; Hong Liang; John F Hancock; Alemayehu A Gorfe
Journal:  Biophys J       Date:  2016-03-08       Impact factor: 4.033

9.  H-Ras forms dimers on membrane surfaces via a protein-protein interface.

Authors:  Wan-Chen Lin; Lars Iversen; Hsiung-Lin Tu; Christopher Rhodes; Sune M Christensen; Jeffrey S Iwig; Scott D Hansen; William Y C Huang; Jay T Groves
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-10       Impact factor: 11.205

10.  GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.

Authors:  Shaoyong Lu; Avik Banerjee; Hyunbum Jang; Jian Zhang; Vadim Gaponenko; Ruth Nussinov
Journal:  J Biol Chem       Date:  2015-10-09       Impact factor: 5.157
  10 in total
  10 in total

Review 1.  Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Authors:  Shaoyong Lu; Hyunbum Jang; Shuo Gu; Jian Zhang; Ruth Nussinov
Journal:  Chem Soc Rev       Date:  2016-07-11       Impact factor: 54.564

2.  Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.

Authors:  Abdallah Sayyed-Ahmad; Priyanka Prakash; Alemayehu A Gorfe
Journal:  Proteins       Date:  2017-05-31

3.  Computational Modeling Reveals that Signaling Lipids Modulate the Orientation of K-Ras4A at the Membrane Reflecting Protein Topology.

Authors:  Zhen-Lu Li; Matthias Buck
Journal:  Structure       Date:  2017-03-09       Impact factor: 5.006

4.  Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1.

Authors:  Liqun Zhang; Matthias Buck
Journal:  J Phys Chem B       Date:  2017-02-08       Impact factor: 2.991

5.  K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function.

Authors:  Shufen Cao; Stacey Chung; SoonJeung Kim; Zhenlu Li; Danny Manor; Matthias Buck
Journal:  J Biol Chem       Date:  2019-02-21       Impact factor: 5.157

6.  The Relationship between APOL1 Structure and Function: Clinical Implications.

Authors:  Sethu M Madhavan; Matthias Buck
Journal:  Kidney360       Date:  2020-11-04

7.  Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes.

Authors:  Suparna Sarkar-Banerjee; Abdallah Sayyed-Ahmad; Priyanka Prakash; Kwang-Jin Cho; M Neal Waxham; John F Hancock; Alemayehu A Gorfe
Journal:  J Am Chem Soc       Date:  2017-09-18       Impact factor: 15.419

8.  The protonation states of GTP and GppNHp in Ras proteins.

Authors:  Daniel Mann; Jörn Güldenhaupt; Jonas Schartner; Klaus Gerwert; Carsten Kötting
Journal:  J Biol Chem       Date:  2018-01-30       Impact factor: 5.157

Review 9.  Membrane orientation dynamics of lipid-modified small GTPases.

Authors:  Priyanka Prakash; Alemayehu A Gorfe
Journal:  Small GTPases       Date:  2016-08-11

10.  Three distinct regions of cRaf kinase domain interact with membrane.

Authors:  Priyanka Prakash; John F Hancock; Alemayehu A Gorfe
Journal:  Sci Rep       Date:  2019-02-14       Impact factor: 4.379
  10 in total

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