Literature DB >> 20044260

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

Robert W Huigens1, Samuel Reyes, Catherine S Reed, Cynthia Bunders, Steven A Rogers, Andrew T Steinhauer, Christian Melander.   

Abstract

Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. Copyright 2009. Published by Elsevier Ltd.

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Year:  2009        PMID： 20044260     DOI： 10.1016/j.bmc.2009.12.003

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold.

Authors:  T Vu Nguyen; Bradley M Minrovic; Roberta J Melander; Christian Melander
Journal:  ChemMedChem       Date:  2019-03-21       Impact factor: 3.466

2.  A Whole-Cell Screen Identifies Small Bioactives That Synergize with Polymyxin and Exhibit Antimicrobial Activities against Multidrug-Resistant Bacteria.

Authors:  Shawn M Zimmerman; Audrey-Ann J Lafontaine; Carmen M Herrera; Amanda B Mclean; M Stephen Trent
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

3.  Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives.

Authors:  Mike A Richardson; Robert E Furlani; Brendan K Podell; David F Ackart; Jessica D Haugen; Roberta J Melander; Christian Melander; Randall J Basaraba
Journal:  Tetrahedron Lett       Date:  2015       Impact factor: 2.415

4.  Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Authors:  Matthew D Stephens; Veroncia B Hubble; Robert K Ernst; Monique L van Hoek; Roberta J Melander; John Cavanagh; Christian Melander
Journal:  Medchemcomm       Date:  2015-09-30       Impact factor: 3.597

5.  The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

Authors:  Erick A Lindsey; Christopher M Brackett; Trey Mullikin; Cristina Alcaraz; Christian Melander
Journal:  Medchemcomm       Date:  2012-09-18       Impact factor: 3.597

6.  Synthesis and investigation of novel benzimidazole derivatives as antifungal agents.

Authors:  Nishad Thamban Chandrika; Sanjib K Shrestha; Huy X Ngo; Sylvie Garneau-Tsodikova
Journal:  Bioorg Med Chem       Date:  2016-06-04       Impact factor: 3.641

7.  5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms.

Authors:  Bram H Frohock; Jessica M Gilbertie; Jennifer C Daiker; Lauren V Schnabel; Joshua G Pierce
Journal:  Chembiochem       Date:  2019-12-30       Impact factor: 3.164

Review 8.  Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids.

Authors:  Ali Al-Mourabit; Manuel A Zancanella; Supriya Tilvi; Daniel Romo
Journal:  Nat Prod Rep       Date:  2011-05-09       Impact factor: 13.423

9.  Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides.

Authors:  Maja Cindrić; Mihaela Perić; Marijeta Kralj; Irena Martin-Kleiner; Marie-Hélène David-Cordonnier; Hana Čipčić Paljetak; Mario Matijašić; Donatella Verbanac; Grace Karminski-Zamola; Marijana Hranjec
Journal:  Mol Divers       Date:  2018-03-20       Impact factor: 2.943

10.  Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae.

Authors:  Roberta J Worthington; Cynthia A Bunders; Catherine S Reed; Christian Melander
Journal:  ACS Med Chem Lett       Date:  2012-02-04       Impact factor: 4.345
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