Literature DB >> 20428587

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity.

Zhaoming Su1, Steven A Rogers, W Steve McCall, Alicia C Smith, Sindhu Ravishankar, Trey Mullikin, Christian Melander.   

Abstract

A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20428587     DOI： 10.1039/c001479f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  2-Aminopyrimidine as a novel scaffold for biofilm modulation.

Authors:  Erick A Lindsey; Roberta J Worthington; Cristina Alcaraz; Christian Melander
Journal:  Org Biomol Chem       Date:  2012-02-02       Impact factor: 3.876

2.  Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Authors:  Matthew D Stephens; Veroncia B Hubble; Robert K Ernst; Monique L van Hoek; Roberta J Melander; John Cavanagh; Christian Melander
Journal:  Medchemcomm       Date:  2015-09-30       Impact factor: 3.597
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.