Literature DB >> 26865382

Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness.

Samsun Lampotang1,2,3,4, David E Lizdas1,2,3, Hartmut Derendorf5, Nikolaus Gravenstein1,2, Benjamin Lok6, John P Quarles7.   

Abstract

We present a race-specific model of propofol-induced loss of consciousness that is based on pharmacodynamic data collected and adapted from the peer-reviewed literature. In the proposed race-specific model that includes EC05 and EC95 concentrations, the median (EC50) (and where available 95%CI) propofol concentrations at the effect site compartment for propofol-induced loss of consciousness for whites, Chinese, blacks, and Indians are 2.8 (2.7-2.9), 2.2 (2.2-2.3), 2.0, and 1.9 μg/mL, respectively.
© 2016, The American College of Clinical Pharmacology.

Entities:  

Keywords:  EC50; effect site compartment; loss of consciousness; propofol; race-specific model

Mesh：

Substances：

Year:  2016        PMID： 26865382      PMCID： PMC4981563          DOI： 10.1002/jcph.716

Source DB:  PubMed          Journal:  J Clin Pharmacol        ISSN： 0091-2700            Impact factor:   3.126


  16 in total

1.  The recovery of Senegalese African blacks from intravenous anesthesia with propofol and remifentanil is slower than that of Caucasians.

Authors:  O Ortolani; A Conti; B Sall-Ka; J P Salleras; E Diouf; O Kane; S J Roberts; G P Novelli
Journal:  Anesth Analg       Date:  2001-11       Impact factor: 5.108

2.  Pharmacokinetic model driven infusion of propofol in children.

Authors:  B Marsh; M White; N Morton; G N Kenny
Journal:  Br J Anaesth       Date:  1991-07       Impact factor: 9.166

3.  Effect site concentration during propofol TCI sedation: a comparison of sedation score with two pharmacokinetic models.

Authors:  A R Barakat; N Sutcliffe; M Schwab
Journal:  Anaesthesia       Date:  2007-07       Impact factor: 6.955

4.  Targeting effect compartment or central compartment concentration of propofol: what predicts loss of consciousness?

Authors:  H G Wakeling; J B Zimmerman; S Howell; P S Glass
Journal:  Anesthesiology       Date:  1999-01       Impact factor: 7.892

5.  Geographic differences in the target-controlled infusion estimated concentration of propofol: bispectral index response curves.

Authors:  Ashraf A Dahaba; Taidi Zhong; Hui Shun Lu; Helmar Bornemann; Markus Liebmann; Georg Wilfinger; Gilbert Reibnegger; Helfried Metzler
Journal:  Can J Anaesth       Date:  2011-01-25       Impact factor: 5.063

6.  The influence of age on propofol pharmacodynamics.

Authors:  T W Schnider; C F Minto; S L Shafer; P L Gambus; C Andresen; D B Goodale; E J Youngs
Journal:  Anesthesiology       Date:  1999-06       Impact factor: 7.892

7.  Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients.

Authors:  Goverdhan D Puri; Preethy J Mathew; J Sethu Madhavan; Harihar V Hegde; Andreas Fiehn
Journal:  J Clin Monit Comput       Date:  2011-10-01       Impact factor: 2.502

8.  Comparison of plasma compartment versus two methods for effect compartment--controlled target-controlled infusion for propofol.

Authors:  M M Struys; T De Smet; B Depoorter; L F Versichelen; E P Mortier; F J Dumortier; S L Shafer; G Rolly
Journal:  Anesthesiology       Date:  2000-02       Impact factor: 7.892

9.  Relationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-points.

Authors:  S E Milne; A Troy; M G Irwin; G N C Kenny
Journal:  Br J Anaesth       Date:  2003-02       Impact factor: 9.166

10.  C50 for propofol-remifentanil target-controlled infusion and bispectral index at loss of consciousness and response to painful stimulus in Chinese patients: a multicenter clinical trial.

Authors:  Zhipeng Xu; Fang Liu; Yun Yue; Tiehu Ye; Bingxi Zhang; Mingzhang Zuo; Mingjun Xu; Rongrong Hao; Yuan Xu; Ning Yang; Xiangming Che
Journal:  Anesth Analg       Date:  2009-02       Impact factor: 5.108
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Authors:  Ashraf A Dahaba; Zhaoyang Xiao; Xiaoling Zhu; Hailong Dong; Lize Xiong; Peter Rehak; Sieglinde Zelzer; Kun Wang; Gilbert Reibnegger
Journal:  J Pharmacokinet Pharmacodyn       Date:  2020-02-25       Impact factor: 2.745

2.  Pharmacokinetic and pharmacodynamic properties of ciprofol emulsion in Chinese subjects: a single center, open-label, single-arm dose-escalation phase 1 study.

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3.  Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use.

Authors:  Damaris Ortiz; Heidi L Lindroth; Tyler Braly; Anthony J Perkins; Sanjay Mohanty; Ashley D Meagher; Sikandar H Khan; Malaz A Boustani; Babar A Khan
Journal:  Sci Rep       Date:  2022-08-24       Impact factor: 4.996

4.  Target controlled infusion total intravenous anaesthesia and Indian patients: Do we need our own data?

Authors:  Goverdhan Dutt Puri
Journal:  Indian J Anaesth       Date:  2018-04
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