Literature DB >> 26795714

Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by (129)Xe hyperCEST NMR.

Joel A Finbloom1, Clancy C Slack2, Carson J Bruns1, Keunhong Jeong2, David E Wemmer3, Alexander Pines2, Matthew B Francis2.   

Abstract

We report a method for blocking interactions between (129)Xe and cucurbit[6]uril (CB6) until activation by a specific chemical event. We synthesized a CB6-rotaxane that allowed no (129)Xe interaction with the CB6 macrocycle component until a cleavage event released the CB6, which then produced a (129)Xe@CB6 NMR signal. This contrast-upon-activation (129)Xe NMR platform allows for modular synthesis and can be expanded to applications in detection and disease imaging.

Entities:  

Year:  2016        PMID： 26795714     DOI： 10.1039/c5cc10410f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  Cryptophane Nanoscale Assemblies Expand 129Xe NMR Biosensing.

Authors:  Serge D Zemerov; Benjamin W Roose; Mara L Greenberg; Yanfei Wang; Ivan J Dmochowski
Journal:  Anal Chem       Date:  2018-06-01       Impact factor: 6.986

2.  Directly Functionalized Cucurbit[7]uril as a Biosensor for the Selective Detection of Protein Interactions by 129 Xe hyperCEST NMR.

Authors:  Ashley E Truxal; Liping Cao; Lyle Isaacs; David E Wemmer; Alexander Pines
Journal:  Chemistry       Date:  2019-03-29       Impact factor: 5.236

3.  Rotaxane Probes for the Detection of Hydrogen Peroxide by 129 Xe HyperCEST NMR Spectroscopy.

Authors:  Sarah H Klass; Ashley E Truxal; Tahoe A Fiala; Joseph Kelly; Dang Nguyen; Joel A Finbloom; David E Wemmer; Alexander Pines; Matthew B Francis
Journal:  Angew Chem Int Ed Engl       Date:  2019-06-11       Impact factor: 15.336

Review 4.  NMR Hyperpolarization Techniques of Gases.

Authors:  Danila A Barskiy; Aaron M Coffey; Panayiotis Nikolaou; Dmitry M Mikhaylov; Boyd M Goodson; Rosa T Branca; George J Lu; Mikhail G Shapiro; Ville-Veikko Telkki; Vladimir V Zhivonitko; Igor V Koptyug; Oleg G Salnikov; Kirill V Kovtunov; Valerii I Bukhtiyarov; Matthew S Rosen; Michael J Barlow; Shahideh Safavi; Ian P Hall; Leif Schröder; Eduard Y Chekmenev
Journal:  Chemistry       Date:  2016-12-05       Impact factor: 5.236

Review 5.  Molecular Sensing with Host Systems for Hyperpolarized 129Xe.

Authors:  Jabadurai Jayapaul; Leif Schröder
Journal:  Molecules       Date:  2020-10-11       Impact factor: 4.411

6.  A cryptophane-based "turn-on" 129Xe NMR biosensor for monitoring calmodulin.

Authors:  Brittany A Riggle; Mara L Greenberg; Yanfei Wang; Rebecca F Wissner; Serge D Zemerov; E James Petersson; Ivan J Dmochowski
Journal:  Org Biomol Chem       Date:  2017-10-31       Impact factor: 3.876

7.  Detecting protein-protein interactions by Xe-129 NMR.

Authors:  Zhuangyu Zhao; Benjamin W Roose; Serge D Zemerov; Madison A Stringer; Ivan J Dmochowski
Journal:  Chem Commun (Camb)       Date:  2020-09-22       Impact factor: 6.222

8.  An Expanded Palette of Xenon-129 NMR Biosensors.

Authors:  Yanfei Wang; Ivan J Dmochowski
Journal:  Acc Chem Res       Date:  2016-09-19       Impact factor: 22.384

9.  In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor.

Authors:  Francis T Hane; Tao Li; Peter Smylie; Raiili M Pellizzari; Jennifer A Plata; Brenton DeBoef; Mitchell S Albert
Journal:  Sci Rep       Date:  2017-01-20       Impact factor: 4.379

Review 10.  Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Authors:  Jabadurai Jayapaul; Leif Schröder
Journal:  Molecules       Date:  2020-02-20       Impact factor: 4.411
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