Literature DB >> 26553596

Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation.

Kyle J Korshavn1, Anirban Bhunia2, Mi Hee Lim3, Ayyalusamy Ramamoorthy4.   

Abstract

Aggregation at the neuronal cell membrane's lipid bilayer surface is implicated in amyloid-β (Aβ) toxicity associated with Alzheimer's disease; however, structural and mechanistic insights into the process remain scarce. We have identified a conserved binding mode of Aβ40 on lipid bilayer surfaces with a conserved helix containing the self-recognition site (K16-E22).

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Year:  2016        PMID： 26553596      PMCID： PMC4703560          DOI： 10.1039/c5cc08634e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

1.  Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.

Authors:  Christina R Bodner; Christopher M Dobson; Ad Bax
Journal:  J Mol Biol       Date:  2009-05-27       Impact factor: 5.469

2.  Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles.

Authors:  Norbert Kucerka; Yufeng Liu; Nanjun Chu; Horia I Petrache; Stephanie Tristram-Nagle; John F Nagle
Journal:  Biophys J       Date:  2005-01-21       Impact factor: 4.033

3.  Characterization of chemical exchange between soluble and aggregated states of beta-amyloid by solution-state NMR upon variation of salt conditions.

Authors:  Saravanakumar Narayanan; Bernd Reif
Journal:  Biochemistry       Date:  2005-02-08       Impact factor: 3.162

4.  Structure of fully hydrated fluid phase lipid bilayers with monounsaturated chains.

Authors:  Norbert Kucerka; Stephanie Tristram-Nagle; John F Nagle
Journal:  J Membr Biol       Date:  2006-04-08       Impact factor: 1.843

5.  Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters.

Authors:  Maho Utsumi; Yoshiki Yamaguchi; Hiroaki Sasakawa; Naoki Yamamoto; Katsuhiko Yanagisawa; Koichi Kato
Journal:  Glycoconj J       Date:  2009-11       Impact factor: 2.916

Review 6.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Authors:  John Hardy; Dennis J Selkoe
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728

7.  Lipopolysaccharide bound structures of the active fragments of fowlicidin-1, a cathelicidin family of antimicrobial and antiendotoxic peptide from chicken, determined by transferred nuclear Overhauser effect spectroscopy.

Authors:  Anirban Bhunia; Harini Mohanram; Surajit Bhattacharjya
Journal:  Biopolymers       Date:  2009       Impact factor: 2.505

8.  Understanding the molecular basis for the inhibition of the Alzheimer's Abeta-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance relaxation NMR spectroscopy.

Authors:  Julijana Milojevic; Veronica Esposito; Rahul Das; Giuseppe Melacini
Journal:  J Am Chem Soc       Date:  2007-03-17       Impact factor: 15.419

9.  Membrane-bound conformation of a signal peptide: a transferred nuclear Overhauser effect analysis.

Authors:  Z Wang; J D Jones; J Rizo; L M Gierasch
Journal:  Biochemistry       Date:  1993-12-21       Impact factor: 3.162

10.  Amyloid-beta membrane binding and permeabilization are distinct processes influenced separately by membrane charge and fluidity.

Authors:  Pamela T Wong; Joseph A Schauerte; Kathleen C Wisser; Hao Ding; Edgar L Lee; Duncan G Steel; Ari Gafni
Journal:  J Mol Biol       Date:  2008-12-16       Impact factor: 5.469
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  18 in total

1.  Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β.

Authors:  Kyle J Korshavn; Cristina Satriano; Yuxi Lin; Rongchun Zhang; Mark Dulchavsky; Anirban Bhunia; Magdalena I Ivanova; Young-Ho Lee; Carmelo La Rosa; Mi Hee Lim; Ayyalusamy Ramamoorthy
Journal:  J Biol Chem       Date:  2017-02-01       Impact factor: 5.157

Review 2.  Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.

Authors:  Akira Naito; Nobuaki Matsumori; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-06-06       Impact factor: 3.770

3.  Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions.

Authors:  Andrzej Stanisław Cieplak
Journal:  PLoS One       Date:  2017-09-18       Impact factor: 3.240

Review 4.  Structure and Dynamics of Membrane Proteins from Solid-State NMR.

Authors:  Venkata S Mandala; Jonathan K Williams; Mei Hong
Journal:  Annu Rev Biophys       Date:  2018-03-02       Impact factor: 12.981

Review 5.  Cause and consequence of Aβ - Lipid interactions in Alzheimer disease pathogenesis.

Authors:  Vijayaraghavan Rangachari; Dexter N Dean; Pratip Rana; Ashwin Vaidya; Preetam Ghosh
Journal:  Biochim Biophys Acta Biomembr       Date:  2018-03-09       Impact factor: 3.747

6.  Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Authors:  Bikash Ranjan Sahoo; Takuya Genjo; Sarah J Cox; Andrea K Stoddard; G M Anantharamaiah; Carol Fierke; Ayyalusamy Ramamoorthy
Journal:  J Mol Biol       Date:  2018-08-28       Impact factor: 5.469

7.  The on-fibrillation-pathway membrane content leakage and off-fibrillation-pathway lipid mixing induced by 40-residue β-amyloid peptides in biologically relevant model liposomes.

Authors:  Qinghui Cheng; Zhi-Wen Hu; Katelynne E Doherty; Yuto J Tobin-Miyaji; Wei Qiang
Journal:  Biochim Biophys Acta Biomembr       Date:  2018-03-13       Impact factor: 3.747

8.  Acetylation of Aβ40 Alters Aggregation in the Presence and Absence of Lipid Membranes.

Authors:  Albert W Pilkington; Jane Schupp; Morgan Nyman; Stephen J Valentine; David M Smith; Justin Legleiter
Journal:  ACS Chem Neurosci       Date:  2019-12-27       Impact factor: 4.418

9.  Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning.

Authors:  Xuewei Dong; Yunxiang Sun; Guanghong Wei; Ruth Nussinov; Buyong Ma
Journal:  Phys Chem Chem Phys       Date:  2017-10-18       Impact factor: 3.676

10.  Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Authors:  Bikash R Sahoo; Takuya Genjo; Michael Bekier; Sarah J Cox; Andrea K Stoddard; Magdalena Ivanova; Kazuma Yasuhara; Carol A Fierke; Yanzhuang Wang; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2018-11-13       Impact factor: 6.222
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