Literature DB >> 30379172

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Bikash R Sahoo1, Takuya Genjo, Michael Bekier, Sarah J Cox, Andrea K Stoddard, Magdalena Ivanova, Kazuma Yasuhara, Carol A Fierke, Yanzhuang Wang, Ayyalusamy Ramamoorthy.   

Abstract

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the reduced neurotoxicity of nanodisc-bound Aβ oligomers are also reported.

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Year:  2018        PMID： 30379172      PMCID： PMC6247814          DOI： 10.1039/c8cc07921h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

1.  Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Authors:  Johnny Habchi; Sean Chia; Céline Galvagnion; Thomas C T Michaels; Mathias M J Bellaiche; Francesco Simone Ruggeri; Michele Sanguanini; Ilaria Idini; Janet R Kumita; Emma Sparr; Sara Linse; Christopher M Dobson; Tuomas P J Knowles; Michele Vendruscolo
Journal:  Nat Chem       Date:  2018-05-07       Impact factor: 24.427

2.  Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy.

Authors:  András Micsonai; Frank Wien; Linda Kernya; Young-Ho Lee; Yuji Goto; Matthieu Réfrégiers; József Kardos
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-02       Impact factor: 11.205

3.  Small liposomes accelerate the fibrillation of amyloid β (1-40).

Authors:  Mayu S Terakawa; Hisashi Yagi; Masayuki Adachi; Young-Ho Lee; Yuji Goto
Journal:  J Biol Chem       Date:  2014-11-18       Impact factor: 5.157

Review 4.  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Authors:  Christian Haass; Dennis J Selkoe
Journal:  Nat Rev Mol Cell Biol       Date:  2007-02       Impact factor: 94.444

5.  Models of membrane-bound Alzheimer's Abeta peptide assemblies.

Authors:  Yinon Shafrir; Stewart Durell; Nelson Arispe; H Robert Guy
Journal:  Proteins       Date:  2010-10-11

6.  Lipoprotein-based nanoparticles rescue the memory loss of mice with Alzheimer's disease by accelerating the clearance of amyloid-beta.

Authors:  Qingxiang Song; Meng Huang; Lei Yao; Xiaolin Wang; Xiao Gu; Juan Chen; Jun Chen; Jialin Huang; Quanyin Hu; Ting Kang; Zhengxing Rong; Hong Qi; Gang Zheng; Hongzhuan Chen; Xiaoling Gao
Journal:  ACS Nano       Date:  2014-02-21       Impact factor: 15.881

Review 7.  Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

Authors:  Samuel A Kotler; Patrick Walsh; Jeffrey R Brender; Ayyalusamy Ramamoorthy
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

8.  Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

Authors:  Marcus Bokvist; Fredrick Lindström; Anthony Watts; Gerhard Gröbner
Journal:  J Mol Biol       Date:  2004-01-23       Impact factor: 5.469

9.  Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation.

Authors:  Kyle J Korshavn; Anirban Bhunia; Mi Hee Lim; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2016-01-18       Impact factor: 6.222

10.  Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.

Authors:  Adriano Sebollela; Gina-Mirela Mustata; Kevin Luo; Pauline T Velasco; Kirsten L Viola; Erika N Cline; Gajendra S Shekhawat; Kyle C Wilcox; Vinayak P Dravid; William L Klein
Journal:  ACS Chem Neurosci       Date:  2014-11-07       Impact factor: 4.418
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  19 in total

1.  The membrane axis of Alzheimer's nanomedicine.

Authors:  Yuhuan Li; Huayuan Tang; Nicholas Andrikopoulos; Ibrahim Javed; Luca Cecchetto; Aparna Nandakumar; Aleksandr Kakinen; Thomas P Davis; Feng Ding; Pu Chun Ke
Journal:  Adv Nanobiomed Res       Date:  2020-11-26

2.  Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.

Authors:  Young-Ho Lee; Yuxi Lin; Sarah J Cox; Misaki Kinoshita; Bikash R Sahoo; Magdalena Ivanova; Ayyalusamy Ramamoorthy
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2018-11-22       Impact factor: 3.036

3.  NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.

Authors:  Yiling Xiao; Isamu Matsuda; Masafumi Inoue; Tomoya Sasahara; Minako Hoshi; Yoshitaka Ishii
Journal:  J Biol Chem       Date:  2019-11-26       Impact factor: 5.157

Review 4.  High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease.

Authors:  Bikash R Sahoo; Sarah J Cox; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2020-04-17       Impact factor: 6.222

5.  Conformational Tuning of Amylin by Charged Styrene-Maleic-Acid Copolymers.

Authors:  Bikash R Sahoo; Christopher L Souders; Takahiro Watanabe-Nakayama; Zhou Deng; Hunter Linton; Saba Suladze; Magdalena I Ivanova; Bernd Reif; Toshio Ando; Christopher J Martyniuk; Ayyalusamy Ramamoorthy
Journal:  J Mol Biol       Date:  2021-12-06       Impact factor: 5.469

6.  Time-Dependent Lipid Dynamics, Organization and Peptide-Lipid Interaction in Phospholipid Bilayers with Incorporated β-Amyloid Oligomers.

Authors:  Wei Qiang; Katelynne E Doherty; Lukas M Klees; Yuto Tobin-Miyaji
Journal:  J Phys Chem Lett       Date:  2020-09-18       Impact factor: 6.475

7.  Acetylation of Aβ40 Alters Aggregation in the Presence and Absence of Lipid Membranes.

Authors:  Albert W Pilkington; Jane Schupp; Morgan Nyman; Stephen J Valentine; David M Smith; Justin Legleiter
Journal:  ACS Chem Neurosci       Date:  2019-12-27       Impact factor: 4.418

Review 8.  Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Authors:  Phuong H Nguyen; Ayyalusamy Ramamoorthy; Bikash R Sahoo; Jie Zheng; Peter Faller; John E Straub; Laura Dominguez; Joan-Emma Shea; Nikolay V Dokholyan; Alfonso De Simone; Buyong Ma; Ruth Nussinov; Saeed Najafi; Son Tung Ngo; Antoine Loquet; Mara Chiricotto; Pritam Ganguly; James McCarty; Mai Suan Li; Carol Hall; Yiming Wang; Yifat Miller; Simone Melchionna; Birgit Habenstein; Stepan Timr; Jiaxing Chen; Brianna Hnath; Birgit Strodel; Rakez Kayed; Sylvain Lesné; Guanghong Wei; Fabio Sterpone; Andrew J Doig; Philippe Derreumaux
Journal:  Chem Rev       Date:  2021-02-05       Impact factor: 60.622

9.  Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins.

Authors:  Michele F Sciacca; Fabio Lolicato; Carmelo Tempra; Federica Scollo; Bikash R Sahoo; Matthew D Watson; Sara García-Viñuales; Danilo Milardi; Antonio Raudino; Jennifer C Lee; Ayyalusamy Ramamoorthy; Carmelo La Rosa
Journal:  ACS Chem Neurosci       Date:  2020-12-03       Impact factor: 4.418

10.  Ion channel formation by N-terminally truncated Aβ (4-42): relevance for the pathogenesis of Alzheimer's disease.

Authors:  Abhijith G Karkisaval; Agueda Rostagno; Rustam Azimov; Deependra K Ban; Jorge Ghiso; Bruce L Kagan; Ratnesh Lal
Journal:  Nanomedicine       Date:  2020-06-10       Impact factor: 5.307
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