| Literature DB >> 12130773 |
Abstract
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance.Entities:
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Year: 2002 PMID： 12130773 DOI： 10.1126/science.1072994
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728