| Literature DB >> 26516117 |
Laura R Ment1, Ulrika Ådén2, Charles R Bauer3, Henrietta S Bada4, Waldemar A Carlo5, Jeffrey R Kaiser6, Aiping Lin7, Charles Michael Cotten8, Jeffrey Murray9, Grier Page10, Mikko Hallman11, Richard P Lifton12, Heping Zhang13.
Abstract
Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.Entities:
Keywords: GWAS; genes; intraventricular hemorrhage; neonate; preterm
Mesh:
Year: 2015 PMID: 26516117 PMCID: PMC4668116 DOI: 10.1053/j.semperi.2015.09.006
Source DB: PubMed Journal: Semin Perinatol ISSN: 0146-0005 Impact factor: 3.300