Mohamed Mohamed1,2, Anna A Penn3,4, Melissa A Oh5,6, Stephanie Barak7. 1. Department of Obstetrics and Gynecology, The George Washington University Hospital, Washington, DC, USA. 2. Department of Neonatology, The Pediatrics Institute Cleveland Clinic Children's, Cleveland, OH, USA. 3. Department of Neonatology, Children's National Hospital, Washington, DC, USA. 4. Department of Pediatrics, Division of Neonatology, NYP- Morgan Stanley Children's Hospital, Columbia University, New York, NY, USA. 5. Department of Neonatology, Children's National Hospital, Washington, DC, USA. research@melissaohmd.org. 6. Department of Pediatrics, Division of Neonatology, Beverly Knight Olson Children's Hospital Navicent Health, Macon, GA, USA. research@melissaohmd.org. 7. Department of Pathology and Laboratory Medicine, The George Washington University Hospital, Washington, DC, USA.
Abstract
OBJECTIVE: The aim of this study was to examine the relationship between chorioamnionitis and vascular malperfusion on placental pathology and intraventricular hemorrhage (IVH) in premature and small for gestational age (SGA) infants. STUDY DESIGN: A retrospective analysis of 263 infants ≤34 weeks gestation or ≤1800 g and their mothers was conducted by chart review for placental pathology and clinical data from 2014 to 2018. Unadjusted and adjusted odds ratios (OR) for the association of placental pathology with IVH were calculated. RESULT: Unadjusted OR showed an association between acute chorioamnionitis and IVH, but logistic regression analysis showed a non-significant adjusted OR between acute or chronic chorioamnionitis with IVH. Maternal vascular malperfusion was significantly associated with increased IVH when controlling for confounders. CONCLUSION: Placental maternal vascular malperfusion is associated with the development of IVH in premature and SGA infants when controlling for other confounders.
OBJECTIVE: The aim of this study was to examine the relationship between chorioamnionitis and vascular malperfusion on placental pathology and intraventricular hemorrhage (IVH) in premature and small for gestational age (SGA) infants. STUDY DESIGN: A retrospective analysis of 263 infants ≤34 weeks gestation or ≤1800 g and their mothers was conducted by chart review for placental pathology and clinical data from 2014 to 2018. Unadjusted and adjusted odds ratios (OR) for the association of placental pathology with IVH were calculated. RESULT: Unadjusted OR showed an association between acute chorioamnionitis and IVH, but logistic regression analysis showed a non-significant adjusted OR between acute or chronic chorioamnionitis with IVH. Maternal vascular malperfusion was significantly associated with increased IVH when controlling for confounders. CONCLUSION: Placental maternal vascular malperfusion is associated with the development of IVH in premature and SGA infants when controlling for other confounders.
Authors: P Toti; R N Laurini; M Stumpo; E Picciolini; T Todros; P Tanganelli; G Buonocore; R Bracci Journal: J Pediatr Date: 2001-01 Impact factor: 4.406
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