John M Dagle1, Kelli K Ryckman2, Cassandra N Spracklen3, Allison M Momany2, C Michael Cotten4, Joshua Levy5, Grier P Page6, Edward F Bell2, Waldemar A Carlo7, Seetha Shankaran8, Ronald N Goldberg4, Richard A Ehrenkranz9, Jon E Tyson10, Barbara J Stoll11, Jeffrey C Murray2. 1. Department of Pediatrics, University of Iowa, Iowa City, IA, USA. john-dagle@uiowa.edu. 2. Department of Pediatrics, University of Iowa, Iowa City, IA, USA. 3. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 4. Department of Pediatrics, Duke University, Durham, NC, USA. 5. Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Durham, NC, USA. 6. Social, Statistical and Environmental Sciences Unit, RTI International, Atlanta, GA, USA. 7. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA. 8. Department of Pediatrics, Wayne State University, Detroit, MI, USA. 9. Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA. 10. Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA. 11. Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Abstract
OBJECTIVE: Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants. STUDY DESIGN: Preterm infants (n = 1013) enrolled at NICHD Neonatal Research Network sites were phenotyped for PDA. DNA was genotyped for 1634 single nucleotide polymorphisms (SNPs) from candidate genes. Analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables. RESULTS: SNPs in several genes were associated with the clinical diagnosis of PDA and with surgical ligation in extremely preterm neonates diagnosed with PDA (p < 0.01). None of the associations were significant after correction for multiple comparisons. CONCLUSION: We identified several common genetic variants associated with PDA. These findings may inform further studies on genetic risk factors for PDA in preterm infants.
OBJECTIVE:Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants. STUDY DESIGN: Preterm infants (n = 1013) enrolled at NICHD Neonatal Research Network sites were phenotyped for PDA. DNA was genotyped for 1634 single nucleotide polymorphisms (SNPs) from candidate genes. Analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables. RESULTS: SNPs in several genes were associated with the clinical diagnosis of PDA and with surgical ligation in extremely preterm neonates diagnosed with PDA (p < 0.01). None of the associations were significant after correction for multiple comparisons. CONCLUSION: We identified several common genetic variants associated with PDA. These findings may inform further studies on genetic risk factors for PDA in preterm infants.
Authors: Jonathan L Slaughter; Patricia B Reagan; Roopali V Bapat; Thomas B Newman; Mark A Klebanoff Journal: Eur J Pediatr Date: 2016-02-15 Impact factor: 3.183
Authors: Kathryn N Ivey; David Sutcliffe; James Richardson; Ronald I Clyman; Joseph A Garcia; Deepak Srivastava Journal: Circ Res Date: 2008-07-17 Impact factor: 17.367
Authors: Marco Matejcic; Edward J Saunders; Tokhir Dadaev; Mark N Brook; Kan Wang; Xin Sheng; Ali Amin Al Olama; Fredrick R Schumacher; Sue A Ingles; Koveela Govindasami; Sara Benlloch; Sonja I Berndt; Demetrius Albanes; Stella Koutros; Kenneth Muir; Victoria L Stevens; Susan M Gapstur; Catherine M Tangen; Jyotsna Batra; Judith Clements; Henrik Gronberg; Nora Pashayan; Johanna Schleutker; Alicja Wolk; Catharine West; Lorelei Mucci; Peter Kraft; Géraldine Cancel-Tassin; Karina D Sorensen; Lovise Maehle; Eli M Grindedal; Sara S Strom; David E Neal; Freddie C Hamdy; Jenny L Donovan; Ruth C Travis; Robert J Hamilton; Barry Rosenstein; Yong-Jie Lu; Graham G Giles; Adam S Kibel; Ana Vega; Jeanette T Bensen; Manolis Kogevinas; Kathryn L Penney; Jong Y Park; Janet L Stanford; Cezary Cybulski; Børge G Nordestgaard; Hermann Brenner; Christiane Maier; Jeri Kim; Manuel R Teixeira; Susan L Neuhausen; Kim De Ruyck; Azad Razack; Lisa F Newcomb; Davor Lessel; Radka Kaneva; Nawaid Usmani; Frank Claessens; Paul A Townsend; Manuela Gago-Dominguez; Monique J Roobol; Florence Menegaux; Kay-Tee Khaw; Lisa A Cannon-Albright; Hardev Pandha; Stephen N Thibodeau; Daniel J Schaid; Fredrik Wiklund; Stephen J Chanock; Douglas F Easton; Rosalind A Eeles; Zsofia Kote-Jarai; David V Conti; Christopher A Haiman Journal: Nat Commun Date: 2018-11-05 Impact factor: 14.919