Literature DB >> 26346514

Progress in BazookaSPECT: High-Resolution, Dynamic Scintigraphy with Large-Area Imagers.

Brian W Miller1, H Bradford Barber2, Harrison H Barrett2, Zhonglin Liu2, Vivek V Nagarkar3, Lars R Furenlid2.   

Abstract

We present recent progress in BazookaSPECT, a high-resolution, photon-counting gamma-ray detector. It is a new class of scintillation detector that combines columnar scintillators, image intensifiers, and CCD (charge-coupled device) or CMOS (complementary metal-oxide semiconductors) sensors for high-resolution imaging. A key feature of the BazookaSPECT paradigm is the capability to easily design custom detectors in terms of the desired intrinsic detector resolution and event detection rate. This capability is possible because scintillation light is optically amplified by the image intensifier prior to being imaging onto the CCD/CMOS sensor, thereby allowing practically any consumer-grade CCD/CMOS sensor to be used for gamma-ray imaging. Recent efforts have been made to increase the detector area by incorporating fiber-optic tapers between the scintillator and image intensifier, resulting in a 16× increase in detector area. These large-area BazookaSPECT detectors can be used for full-body imaging and we present preliminary results of their use as dynamic scintigraphy imagers for mice and rats. Also, we discuss ongoing and future developments in BazookaSPECT and the improved event-detection rate capability that is achieved using Graphics Processing Units (GPUs), multi-core processors, and new high-speed, USB 3.0 CMOS cameras.

Entities:  

Keywords:  BazookaSPECT; columnar scintillators; dynamic scintigraphy; gamma-ray imaging; small-animal imaging

Year:  2012        PMID: 26346514      PMCID: PMC4558910          DOI: 10.1117/12.966810

Source DB:  PubMed          Journal:  Proc SPIE Int Soc Opt Eng        ISSN: 0277-786X


  7 in total

1.  Analytic determination of pinhole collimator sensitivity with penetration.

Authors:  S D Metzler; J E Bowsher; M F Smith; R J Jaszczak
Journal:  IEEE Trans Med Imaging       Date:  2001-08       Impact factor: 10.048

2.  Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT.

Authors:  R J Jaszczak; J Li; H Wang; M R Zalutsky; R E Coleman
Journal:  Phys Med Biol       Date:  1994-03       Impact factor: 3.609

Review 3.  The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging.

Authors:  Freek Beekman; Frans van der Have
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-02       Impact factor: 9.236

4.  Photon-counting versus an integrating CCD-based gamma camera: important consequences for spatial resolution.

Authors:  Freek J Beekman; Gerralt A de Vree
Journal:  Phys Med Biol       Date:  2005-05-25       Impact factor: 3.609

5.  Photon-counting gamma camera based on columnar CsI(Tl) optically coupled to a back-illuminated CCD.

Authors:  Brian W Miller; H Bradford Barber; Harrison H Barrett; Liying Chen; Sean J Taylor
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2007-01-01

6.  Spatial Pileup Considerations for Pixellated Gamma -ray Detectors.

Authors:  L R Furenlid; E Clarkson; D G Marks; H H Barrett
Journal:  IEEE Nucl Sci Symp Conf Rec (1997)       Date:  2002-08-06

7.  Maximum-Likelihood Methods for Processing Signals From Gamma-Ray Detectors.

Authors:  Harrison H Barrett; William C J Hunter; Brian William Miller; Stephen K Moore; Yichun Chen; Lars R Furenlid
Journal:  IEEE Trans Nucl Sci       Date:  2009-06-01       Impact factor: 1.679

  7 in total
  9 in total

1.  A SPECT imager with synthetic collimation.

Authors:  Ronan J Havelin; Brian W Miller; Harrison H Barrett; Lars R Furenlid; J M Murphy; Mark J Foley
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2013-08-25

2.  Modular platform for low-light microscopy.

Authors:  Tae Jin Kim; Silvan Tuerkcan; Andrew Ceballos; Guillem Pratx
Journal:  Biomed Opt Express       Date:  2015-10-27       Impact factor: 3.732

3.  A Prototype Detector for a Novel High-Resolution PET System: BazookaPET.

Authors:  Ryeojin Park; Brian W Miller; Abhinav K Jha; Lars R Furenlid; William C J Hunter; Harrison H Barrett
Journal:  IEEE Nucl Sci Symp Conf Rec (1997)       Date:  2012 Oct-Nov

4.  Characterization of "γ-Eye": a Low-Cost Benchtop Mouse-Sized Gamma Camera for Dynamic and Static Imaging Studies.

Authors:  Maria Georgiou; Eleftherios Fysikopoulos; Konstantinos Mikropoulos; Eirini Fragogeorgi; George Loudos
Journal:  Mol Imaging Biol       Date:  2017-06       Impact factor: 3.488

5.  RADIANCE AND PHOTON NOISE: Imaging in geometrical optics, physical optics, quantum optics and radiology.

Authors:  Harrison H Barrett; Kyle J Myers; Luca Caucci
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2014-09-12

6.  Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera.

Authors:  Brian W Miller; Sofia H L Frost; Shani L Frayo; Aimee L Kenoyer; Erlinda Santos; Jon C Jones; Damian J Green; Donald K Hamlin; D Scott Wilbur; Darrell R Fisher; Johnnie J Orozco; Oliver W Press; John M Pagel; Brenda M Sandmaier
Journal:  Med Phys       Date:  2015-07       Impact factor: 4.071

7.  The iQID camera: An ionizing-radiation quantum imaging detector.

Authors:  Brian W Miller; Stephanie J Gregory; Erin S Fuller; Harrison H Barrett; H Bradford Barber; Lars R Furenlid
Journal:  Nucl Instrum Methods Phys Res A       Date:  2014-12-11       Impact factor: 1.455

8.  Design and performance of a small-animal imaging system using synthetic collimation.

Authors:  R J Havelin; B W Miller; H H Barrett; L R Furenlid; J M Murphy; R M Dwyer; M J Foley
Journal:  Phys Med Biol       Date:  2013-04-26       Impact factor: 3.609

9.  Imaging properties of pixellated scintillators with deep pixels.

Authors:  H Bradford Barber; David Fastje; Daniel Lemieux; Gary P Grim; Lars R Furenlid; Brian W Miller; Philip Parkhurst; Vivek V Nagarkar
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2014-08-17
  9 in total

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