Literature DB >> 26166921

The iQID camera: An ionizing-radiation quantum imaging detector.

Brian W Miller1, Stephanie J Gregory2, Erin S Fuller2, Harrison H Barrett3, H Bradford Barber3, Lars R Furenlid3.   

Abstract

We have developed and tested a novel, ionizing-radiation Quantum Imaging Detector (iQID). This scintillation-based detector was originally developed as a high-resolution gamma-ray imager, called BazookaSPECT, for use in single-photon emission computed tomography (SPECT). Recently, we have investigated the detector's response and imaging potential with other forms of ionizing radiation including alpha, neutron, beta, and fission fragment particles. The confirmed response to this broad range of ionizing radiation has prompted its new title. The principle operation of the iQID camera involves coupling a scintillator to an image intensifier. The scintillation light generated by particle interactions is optically amplified by the intensifier and then re-imaged onto a CCD/CMOS camera sensor. The intensifier provides sufficient optical gain that practically any CCD/CMOS camera can be used to image ionizing radiation. The spatial location and energy of individual particles are estimated on an event-by-event basis in real time using image analysis algorithms on high-performance graphics processing hardware. Distinguishing features of the iQID camera include portability, large active areas, excellent detection efficiency for charged particles, and high spatial resolution (tens of microns). Although modest, iQID has energy resolution that is sufficient to discriminate between particles. Additionally, spatial features of individual events can be used for particle discrimination. An important iQID imaging application that has recently been developed is real-time, single-particle digital autoradiography. We present the latest results and discuss potential applications.

Entities:  

Keywords:  BazookaSPECT; Charged particle imaging detectors; Digital autoradiography; Ionizing radiation

Year:  2014        PMID: 26166921      PMCID: PMC4497505          DOI: 10.1016/j.nima.2014.05.070

Source DB:  PubMed          Journal:  Nucl Instrum Methods Phys Res A        ISSN: 0168-9002            Impact factor:   1.455


  7 in total

1.  Measurement of the energy spectrum of cosmic-ray induced neutrons aboard an ER-2 high-altitude airplane.

Authors:  P Goldhagen; M Reginatto; T Kniss; J W Wilson; R C Singleterry; I W Jones; W Van Steveninck
Journal:  Nucl Instrum Methods Phys Res A       Date:  2002-01-01       Impact factor: 1.455

2.  2003: a centennial of spinthariscope and scintillation counting.

Authors:  Z I Kolar; W Den Hollander
Journal:  Appl Radiat Isot       Date:  2004 Aug-Sep       Impact factor: 1.513

3.  A Prototype Detector for a Novel High-Resolution PET System: BazookaPET.

Authors:  Ryeojin Park; Brian W Miller; Abhinav K Jha; Lars R Furenlid; William C J Hunter; Harrison H Barrett
Journal:  IEEE Nucl Sci Symp Conf Rec (1997)       Date:  2012 Oct-Nov

4.  Recent advances in BazookaSPECT: Real-time data processing and the development of a gamma-ray microscope.

Authors:  Brian W Miller; Harrison H Barrett; Lars R Furenlid; H Bradford Barber; Robert J Hunter
Journal:  Nucl Instrum Methods Phys Res A       Date:  2008-06-11       Impact factor: 1.455

5.  Photon-counting gamma camera based on columnar CsI(Tl) optically coupled to a back-illuminated CCD.

Authors:  Brian W Miller; H Bradford Barber; Harrison H Barrett; Liying Chen; Sean J Taylor
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2007-01-01

6.  Progress in BazookaSPECT: High-Resolution, Dynamic Scintigraphy with Large-Area Imagers.

Authors:  Brian W Miller; H Bradford Barber; Harrison H Barrett; Zhonglin Liu; Vivek V Nagarkar; Lars R Furenlid
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2012-08-12

7.  Maximum-Likelihood Methods for Processing Signals From Gamma-Ray Detectors.

Authors:  Harrison H Barrett; William C J Hunter; Brian William Miller; Stephen K Moore; Yichun Chen; Lars R Furenlid
Journal:  IEEE Trans Nucl Sci       Date:  2009-06-01       Impact factor: 1.679

  7 in total
  21 in total

1.  Modular low-light microscope for imaging cellular bioluminescence and radioluminescence.

Authors:  Tae Jin Kim; Silvan Türkcan; Guillem Pratx
Journal:  Nat Protoc       Date:  2017-04-20       Impact factor: 13.491

2.  RADIANCE AND PHOTON NOISE: Imaging in geometrical optics, physical optics, quantum optics and radiology.

Authors:  Harrison H Barrett; Kyle J Myers; Luca Caucci
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2014-09-12

3.  Estimating ROI activity concentration with photon-processing and photon-counting SPECT imaging systems.

Authors:  Abhinav K Jha; Eric C Frey
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2015-04-13

4.  Singular value decomposition for photon-processing nuclear imaging systems and applications for reconstruction and computing null functions.

Authors:  Abhinav K Jha; Harrison H Barrett; Eric C Frey; Eric Clarkson; Luca Caucci; Matthew A Kupinski
Journal:  Phys Med Biol       Date:  2015-09-09       Impact factor: 3.609

5.  Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera.

Authors:  Brian W Miller; Sofia H L Frost; Shani L Frayo; Aimee L Kenoyer; Erlinda Santos; Jon C Jones; Damian J Green; Donald K Hamlin; D Scott Wilbur; Darrell R Fisher; Johnnie J Orozco; Oliver W Press; John M Pagel; Brenda M Sandmaier
Journal:  Med Phys       Date:  2015-07       Impact factor: 4.071

6.  PEGylated and Non-PEGylated TCP-1 Probes for Imaging of Colorectal Cancer.

Authors:  Zhonglin Liu; Brian D Gray; Christy Barber; Li Wan; Lars R Furenlid; Rongguang Liang; Zheng Li; James M Woolfenden; Koon Y Pak; Diego R Martin
Journal:  Mol Imaging Biol       Date:  2021-11-29       Impact factor: 3.484

7.  α-Imaging Confirmed Efficient Targeting of CD45-Positive Cells After 211At-Radioimmunotherapy for Hematopoietic Cell Transplantation.

Authors:  Sofia H L Frost; Brian W Miller; Tom A Bäck; Erlinda B Santos; Donald K Hamlin; Sue E Knoblaugh; Shani L Frayo; Aimee L Kenoyer; Rainer Storb; Oliver W Press; D Scott Wilbur; John M Pagel; Brenda M Sandmaier
Journal:  J Nucl Med       Date:  2015-09-03       Impact factor: 10.057

8.  Molecular Imaging in the College of Optical Sciences - An Overview of Two Decades of Instrumentation Development.

Authors:  Lars R Furenlid; Harrison H Barrett; H Bradford Barber; Eric W Clarkson; Matthew A Kupinski; Zhonglin Liu; Gail D Stevenson; James M Woolfenden
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2014-08-17

Review 9.  Internal microdosimetry of alpha-emitting radionuclides.

Authors:  Werner Hofmann; Wei Bo Li; Werner Friedland; Brian W Miller; Balázs Madas; Manuel Bardiès; Imre Balásházy
Journal:  Radiat Environ Biophys       Date:  2019-12-21       Impact factor: 1.925

10.  Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization.

Authors:  Alexander N Garcia; Nancy G Casanova; Daniel G Valera; Xiaoguang Sun; Jin H Song; Carrie L Kempf; Liliana Moreno-Vinasco; Kimberlie Burns; Tadeo Bermudez; Mia Valdez; Genesis Cuellar; Taylor Gregory; Radu C Oita; Vivian Reyes Hernon; Christy Barber; Sara M Camp; Diego Martin; Zhonglin Liu; Christian Bime; Saad Sammani; Anne E Cress; Joe Gn Garcia
Journal:  Transl Res       Date:  2021-06-15       Impact factor: 7.012

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