Maria Georgiou1, Eleftherios Fysikopoulos2, Konstantinos Mikropoulos3, Eirini Fragogeorgi4, George Loudos3,4. 1. BET Solutions, R & D, Athens, Greece. mgeorgiou@betsolutions.gr. 2. BET Solutions, R & D, Athens, Greece. 3. Department of Biomedical Engineering, Technological Educational Institute of Athens, Athens, Greece. 4. National Centre for Scientific Research NCSR "Demokritos", Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, Athens, Greece.
Abstract
PURPOSE: Several preclinical imaging systems are commercially available, but their purchase and maintenance costs make them unaffordable for the majority of small- and medium-sized groups. Taking into account the needs of average users, we developed "γ-eye", a mouse-sized, benchtop γ-camera suitable for in vivo scintigraphic imaging. PROCEDURES: The γ-eye is based on two position-sensitive photomultiplier tubes, coupled to a CsI(Na) pixelated scintillator and a low-energy lead collimator with parallel hexagonal holes. RESULTS: The spatial resolution of the system is 2 mm at 0 mm. The energy resolution is 26 % at 140 keV and the maximum recorded sensitivity 210 cps/MBq. The system was evaluated in a proof-of-concept animal study, using three different clinical Tc-99m-labeled radiopharmaceuticals. Phantom and animal studies demonstrate its ability to provide semiquantitative results even for short scans. CONCLUSIONS: Systems' performance, dimensions, and cost make γ-eye a unique solution for efficient whole-body mouse nuclear imaging.
PURPOSE: Several preclinical imaging systems are commercially available, but their purchase and maintenance costs make them unaffordable for the majority of small- and medium-sized groups. Taking into account the needs of average users, we developed "γ-eye", a mouse-sized, benchtop γ-camera suitable for in vivo scintigraphic imaging. PROCEDURES: The γ-eye is based on two position-sensitive photomultiplier tubes, coupled to a CsI(Na) pixelated scintillator and a low-energy lead collimator with parallel hexagonal holes. RESULTS: The spatial resolution of the system is 2 mm at 0 mm. The energy resolution is 26 % at 140 keV and the maximum recorded sensitivity 210 cps/MBq. The system was evaluated in a proof-of-concept animal study, using three different clinical Tc-99m-labeled radiopharmaceuticals. Phantom and animal studies demonstrate its ability to provide semiquantitative results even for short scans. CONCLUSIONS: Systems' performance, dimensions, and cost make γ-eye a unique solution for efficient whole-body mouse nuclear imaging.
Entities:
Keywords:
Performance evaluation; Position sensitive photomultiplier tube; Scintigraphic small animal imaging; Single photon emission
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