Literature DB >> 26297167

Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation.

Chuan Zhang1, Liangliang Hao1, Colin M Calabrese1, Yu Zhou2, Chung Hang J Choi1, Hang Xing1, Chad A Mirkin1,2.   

Abstract

By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DNA-brush block copolymers; cellular uptake; gene regulation; micelles; spherical nucleic acids

Mesh：

Substances：

Year:  2015        PMID： 26297167      PMCID： PMC4710492          DOI： 10.1002/smll.201501573

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  36 in total

1.  Maximizing DNA loading on a range of gold nanoparticle sizes.

Authors:  Sarah J Hurst; Abigail K R Lytton-Jean; Chad A Mirkin
Journal:  Anal Chem       Date:  2006-12-15       Impact factor: 6.986

2.  Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size.

Authors:  Ganeshchandra Sonavane; Keishiro Tomoda; Kimiko Makino
Journal:  Colloids Surf B Biointerfaces       Date:  2008-07-15       Impact factor: 5.268

3.  Nano-flares for mRNA regulation and detection.

Authors:  Andrew E Prigodich; Dwight S Seferos; Matthew D Massich; David A Giljohann; Brandon C Lane; Chad A Mirkin
Journal:  ACS Nano       Date:  2009-08-25       Impact factor: 15.881

4.  A general approach to DNA-programmable atom equivalents.

Authors:  Chuan Zhang; Robert J Macfarlane; Kaylie L Young; Chung Hang J Choi; Liangliang Hao; Evelyn Auyeung; Guoliang Liu; Xiaozhu Zhou; Chad A Mirkin
Journal:  Nat Mater       Date:  2013-05-19       Impact factor: 43.841

5.  Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates.

Authors:  Chung Hang J Choi; Liangliang Hao; Suguna P Narayan; Evelyn Auyeung; Chad A Mirkin
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-23       Impact factor: 11.205

Review 6.  Nucleic acid/organic polymer hybrid materials: synthesis, superstructures, and applications.

Authors:  Minseok Kwak; Andreas Herrmann
Journal:  Angew Chem Int Ed Engl       Date:  2010-11-08       Impact factor: 15.336

Review 7.  Gold nanoparticles for biology and medicine.

Authors:  David A Giljohann; Dwight S Seferos; Weston L Daniel; Matthew D Massich; Pinal C Patel; Chad A Mirkin
Journal:  Angew Chem Int Ed Engl       Date:  2010-04-26       Impact factor: 15.336

8.  Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.

Authors:  David A Giljohann; Dwight S Seferos; Pinal C Patel; Jill E Millstone; Nathaniel L Rosi; Chad A Mirkin
Journal:  Nano Lett       Date:  2007-11-13       Impact factor: 11.189

9.  An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT.

Authors:  N W Roehm; G H Rodgers; S M Hatfield; A L Glasebrook
Journal:  J Immunol Methods       Date:  1991-09-13       Impact factor: 2.303

10.  Intracellular mRNA regulation with self-assembled locked nucleic acid polymer nanoparticles.

Authors:  Anthony M Rush; David A Nelles; Angela P Blum; Sarah A Barnhill; Erick T Tatro; Gene W Yeo; Nathan C Gianneschi
Journal:  J Am Chem Soc       Date:  2014-05-14       Impact factor: 15.419
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  9 in total

1.  Liposomal Spherical Nucleic Acids for Regulating Long Noncoding RNAs in the Nucleus.

Authors:  Anthony J Sprangers; Liangliang Hao; Resham J Banga; Chad A Mirkin
Journal:  Small       Date:  2016-12-27       Impact factor: 13.281

2.  Preparation and Properties of Nanoparticles, tRNA-Bivalent Metal Cation (Me2+) Complexes, and Prospects of Their Practical Use.

Authors:  V N Danilevich; V V Sorokin; Ya P Moiseev; S V Sizova
Journal:  Dokl Biochem Biophys       Date:  2018-05-19       Impact factor: 0.788

3.  Design strategies for programmable oligonucleotide nanotherapeutics.

Authors:  Fitsum Feleke Sahle; Tao L Lowe
Journal:  Drug Discov Today       Date:  2019-09-13       Impact factor: 7.851

Review 4.  Functional DNA-Polymer Conjugates.

Authors:  Colette J Whitfield; Meizhou Zhang; Pia Winterwerber; Yuzhou Wu; David Y W Ng; Tanja Weil
Journal:  Chem Rev       Date:  2021-03-19       Impact factor: 60.622

5.  Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells.

Authors:  Hongli Li; Binfeng He; Xueping Liu; Jingtong Li; Qian Liu; Weijie Dong; Zhi Xu; Guisheng Qian; Hua Zuo; Changhua Hu; Hang Qian; Chengde Mao; Guansong Wang
Journal:  Theranostics       Date:  2017-06-25       Impact factor: 11.556

6.  Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine.

Authors:  Yangmeihui Song; Wenyu Song; Xiaoli Lan; Weibo Cai; Dawei Jiang
Journal:  Aggregate (Hoboken)       Date:  2021-09-14

Review 7.  Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine.

Authors:  Zhiyong Zhao; Ting Du; Feng Liang; Simin Liu
Journal:  Int J Mol Sci       Date:  2018-08-03       Impact factor: 5.923

Review 8.  DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy.

Authors:  Qingjia Chi; Zichang Yang; Kang Xu; Chunli Wang; Huaping Liang
Journal:  Front Pharmacol       Date:  2020-01-28       Impact factor: 5.810

Review 9.  Gene Regulation Using Spherical Nucleic Acids to Treat Skin Disorders.

Authors:  Thomas R Holmes; Amy S Paller
Journal:  Pharmaceuticals (Basel)       Date:  2020-11-02
  9 in total

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