Literature DB >> 17997588

Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.

David A Giljohann1, Dwight S Seferos, Pinal C Patel, Jill E Millstone, Nathaniel L Rosi, Chad A Mirkin.   

Abstract

The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

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Year:  2007        PMID： 17997588     DOI： 10.1021/nl072471q

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  128 in total

1.  Duplex end breathing determines serum stability and intracellular potency of siRNA-Au NPs.

Authors:  Pinal C Patel; Liangliang Hao; Weng Si Au Yeung; Chad A Mirkin
Journal:  Mol Pharm       Date:  2011-06-28       Impact factor: 4.939

2.  Polyvalent nucleic acid nanostructures.

Authors:  Joshua I Cutler; Ke Zhang; Dan Zheng; Evelyn Auyeung; Andrew E Prigodich; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2011-06-01       Impact factor: 15.419

3.  Spherical nucleic acid nanoparticle conjugates enhance G-quadruplex formation and increase serum protein interactions.

Authors:  Alyssa B Chinen; Chenxia M Guan; Chad A Mirkin
Journal:  Angew Chem Int Ed Engl       Date:  2014-11-13       Impact factor: 15.336

4.  Tailoring DNA structure to increase target hybridization kinetics on surfaces.

Authors:  Andrew E Prigodich; One-Sun Lee; Weston L Daniel; Dwight S Seferos; George C Schatz; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2010-08-11       Impact factor: 15.419

5.  Multifunctional Nanoparticles as Biocompatible Targeted Probes for Human Cancer Diagnosis and Therapy.

Authors:  Ken-Tye Yong; Indrajit Roy; Mark T Swihart; Paras N Prasad
Journal:  J Mater Chem       Date:  2009-01-01

6.  Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells.

Authors:  Ashwath Jayagopal; Kristin C Halfpenny; Jonas W Perez; David W Wright
Journal:  J Am Chem Soc       Date:  2010-07-21       Impact factor: 15.419

7.  Gene regulation with polyvalent siRNA-nanoparticle conjugates.

Authors:  David A Giljohann; Dwight S Seferos; Andrew E Prigodich; Pinal C Patel; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419

8.  Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation.

Authors:  Kevin G Reuter; Jillian L Perry; Dongwook Kim; J Christopher Luft; Rihe Liu; Joseph M DeSimone
Journal:  Nano Lett       Date:  2015-09-30       Impact factor: 11.189

9.  The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles.

Authors:  Haley D Hill; Jill E Millstone; Matthew J Banholzer; Chad A Mirkin
Journal:  ACS Nano       Date:  2009-02-24       Impact factor: 15.881

10.  Curvature-induced base pair "slipping" effects in DNA-nanoparticle hybridization.

Authors:  Haley D Hill; Sarah J Hurst; Chad A Mirkin
Journal:  Nano Lett       Date:  2009-01       Impact factor: 11.189
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