Jiaxin Shao1, Stanislas Rapacchi1, Kim-Lien Nguyen1,2,3, Peng Hu1,4. 1. Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA. 2. Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los, Angeles, California, USA. 3. Division of Cardiology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA. 4. Biomedical Physics Inter-Departmental Graduate Program, University of California, Los Angeles, California, USA.
Abstract
BACKGROUND: To develop an accurate and precise myocardial T1 mapping technique using an inversion recovery spoiled gradient echo readout at 3.0 Tesla (T). THEORY AND METHODS: The modified Look-Locker inversion-recovery (MOLLI) sequence was modified to use fast low angle shot (FLASH) readout, incorporating a BLESSPC (Bloch Equation Simulation with Slice Profile Correction) T1 estimation algorithm, for accurate myocardial T1 mapping. The FLASH-MOLLI with BLESSPC fitting was compared with different approaches and sequences with regards to T1 estimation accuracy, precision and image artifact based on simulation, phantom studies, and in vivo studies of 10 healthy volunteers and three patients at 3.0 Tesla. RESULTS: The FLASH-MOLLI with BLESSPC fitting yields accurate T1 estimation (average error = -5.4 ± 15.1 ms, percentage error = -0.5% ± 1.2%) for T1 from 236-1852 ms and heart rate from 40-100 bpm in phantom studies. The FLASH-MOLLI sequence prevented off-resonance artifacts in all 10 healthy volunteers at 3.0T. In vivo, there was no significant difference between FLASH-MOLLI-derived myocardial T1 values and "ShMOLLI+IE" derived values (1458.9 ± 20.9 ms versus 1464.1 ± 6.8 ms, P = 0.50); However, the average precision by FLASH-MOLLI was significantly better than that generated by "ShMOLLI+IE" (1.84 ± 0.36% variance versus 3.57 ± 0.94%, P < 0.001). CONCLUSION: The FLASH-MOLLI with BLESSPC fitting yields accurate and precise T1 estimation, and eliminates banding artifacts associated with bSSFP at 3.0T.
BACKGROUND: To develop an accurate and precise myocardial T1 mapping technique using an inversion recovery spoiled gradient echo readout at 3.0 Tesla (T). THEORY AND METHODS: The modified Look-Locker inversion-recovery (MOLLI) sequence was modified to use fast low angle shot (FLASH) readout, incorporating a BLESSPC (Bloch Equation Simulation with Slice Profile Correction) T1 estimation algorithm, for accurate myocardial T1 mapping. The FLASH-MOLLI with BLESSPC fitting was compared with different approaches and sequences with regards to T1 estimation accuracy, precision and image artifact based on simulation, phantom studies, and in vivo studies of 10 healthy volunteers and three patients at 3.0 Tesla. RESULTS: The FLASH-MOLLI with BLESSPC fitting yields accurate T1 estimation (average error = -5.4 ± 15.1 ms, percentage error = -0.5% ± 1.2%) for T1 from 236-1852 ms and heart rate from 40-100 bpm in phantom studies. The FLASH-MOLLI sequence prevented off-resonance artifacts in all 10 healthy volunteers at 3.0T. In vivo, there was no significant difference between FLASH-MOLLI-derived myocardial T1 values and "ShMOLLI+IE" derived values (1458.9 ± 20.9 ms versus 1464.1 ± 6.8 ms, P = 0.50); However, the average precision by FLASH-MOLLI was significantly better than that generated by "ShMOLLI+IE" (1.84 ± 0.36% variance versus 3.57 ± 0.94%, P < 0.001). CONCLUSION: The FLASH-MOLLI with BLESSPC fitting yields accurate and precise T1 estimation, and eliminates banding artifacts associated with bSSFP at 3.0T.
Authors: Marcelo Souto Nacif; Evrim B Turkbey; Neville Gai; Saman Nazarian; Rob J van der Geest; Radwa A Noureldin; Christopher T Sibley; Martin Ugander; Songtao Liu; Andrew E Arai; João A C Lima; David A Bluemke Journal: J Magn Reson Imaging Date: 2011-09-23 Impact factor: 4.813
Authors: Mitchell A Cooper; Thanh D Nguyen; Pascal Spincemaille; Martin R Prince; Jonathan W Weinsaft; Yi Wang Journal: Magn Reson Med Date: 2012-01-31 Impact factor: 4.668
Authors: Vanessa M Ferreira; Stefan K Piechnik; Erica Dall'Armellina; Theodoros D Karamitsos; Jane M Francis; Robin P Choudhury; Matthias G Friedrich; Matthew D Robson; Stefan Neubauer Journal: J Cardiovasc Magn Reson Date: 2012-06-21 Impact factor: 5.364
Authors: Stefan K Piechnik; Vanessa M Ferreira; Erica Dall'Armellina; Lowri E Cochlin; Andreas Greiser; Stefan Neubauer; Matthew D Robson Journal: J Cardiovasc Magn Reson Date: 2010-11-19 Impact factor: 5.364
Authors: Theodoros D Karamitsos; Stefan K Piechnik; Sanjay M Banypersad; Marianna Fontana; Ntobeko B Ntusi; Vanessa M Ferreira; Carol J Whelan; Saul G Myerson; Matthew D Robson; Philip N Hawkins; Stefan Neubauer; James C Moon Journal: JACC Cardiovasc Imaging Date: 2013-03-14
Authors: Sebastian Weingärtner; Steen Moeller; Sebastian Schmitter; Edward Auerbach; Peter Kellman; Chetan Shenoy; Mehmet Akçakaya Journal: Magn Reson Med Date: 2017-06-05 Impact factor: 4.668
Authors: Ananna Zaman; Samantha Zhao; Jordana Kron; Antonio Abbate; Anna Tomdio; W Gregory Hundley; Jennifer H Jordan Journal: Curr Cardiol Rep Date: 2022-08-19 Impact factor: 3.955
Authors: Daniel R Messroghli; James C Moon; Vanessa M Ferreira; Lars Grosse-Wortmann; Taigang He; Peter Kellman; Julia Mascherbauer; Reza Nezafat; Michael Salerno; Erik B Schelbert; Andrew J Taylor; Richard Thompson; Martin Ugander; Ruud B van Heeswijk; Matthias G Friedrich Journal: J Cardiovasc Magn Reson Date: 2017-10-09 Impact factor: 5.364