| Literature DB >> 26098680 |
Martin Bachman1, Santiago Uribe-Lewis2, Xiaoping Yang2, Heather E Burgess3, Mario Iurlaro3, Wolf Reik4, Adele Murrell2, Shankar Balasubramanian1.
Abstract
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.Entities:
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Year: 2015 PMID： 26098680 PMCID： PMC5486442 DOI： 10.1038/nchembio.1848
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040