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Literature DB >> 26595486

DNA methylation and hydroxymethylation in hematologic differentiation and transformation.

Abstract

Maintenance of the balance of DNA methylation and demethylation is fundamental for normal cellular development and function. Members of the Ten-Eleven-Translocation (TET) family proteins are Fe(II)-dependent and 2-oxoglutarate-dependent dioxygenases that catalyze sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequent oxidized derivatives in DNA. In addition to their roles as intermediates in DNA demethylation, these oxidized methylcytosines are novel epigenetic modifications of DNA. DNA methylation and hydroxymethylation profiles are markedly disrupted in a wide range of cancers but how these changes are related to the pathogenesis of cancers is still ambiguous. In this review, we discuss the current understanding of TET protein functions in normal and malignant hematopoietic development and the ongoing questions to be resolved.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
DNA

Year: 2015 PMID： 26595486 PMCID： PMC4688184 DOI： 10.1016/j.ceb.2015.10.009

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

81 in total

Review 1. Function and information content of DNA methylation.

Authors: Dirk Schübeler
Journal: Nature Date: 2015-01-15 Impact factor: 49.962

2. CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.

Authors: Tadashi Nakagawa; Lei Lv; Makiko Nakagawa; Yanbao Yu; Chao Yu; Ana C D'Alessio; Keiko Nakayama; Heng-Yu Fan; Xian Chen; Yue Xiong
Journal: Mol Cell Date: 2014-12-31 Impact factor: 17.970

Review 3. DNMT3A in haematological malignancies.

Authors: Liubin Yang; Rachel Rau; Margaret A Goodell
Journal: Nat Rev Cancer Date: 2015-02-19 Impact factor: 60.716

4. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.

Authors: Allison Mayle; Liubin Yang; Benjamin Rodriguez; Ting Zhou; Edmund Chang; Choladda V Curry; Grant A Challen; Wei Li; David Wheeler; Vivienne I Rebel; Margaret A Goodell
Journal: Blood Date: 2015-01-22 Impact factor: 22.113

5. Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.

Authors: Hamza Celik; Cates Mallaney; Alok Kothari; Elizabeth L Ostrander; Elizabeth Eultgen; Andrew Martens; Christopher A Miller; Jasreet Hundal; Jeffery M Klco; Grant A Challen
Journal: Blood Date: 2015-01-22 Impact factor: 22.113

Review 6. TET proteins and 5-methylcytosine oxidation in hematological cancers.

Authors: Myunggon Ko; Jungeun An; William A Pastor; Sergei B Koralov; Klaus Rajewsky; Anjana Rao
Journal: Immunol Rev Date: 2015-01 Impact factor: 12.988

7. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.

Authors: Yiping Wang; Mengtao Xiao; Xiufei Chen; Leilei Chen; Yanping Xu; Lei Lv; Pu Wang; Hui Yang; Shenghong Ma; Huaipeng Lin; Bo Jiao; Ruibao Ren; Dan Ye; Kun-Liang Guan; Yue Xiong
Journal: Mol Cell Date: 2015-01-15 Impact factor: 17.970

8. 5-Hydroxymethylcytosine is a predominantly stable DNA modification.

Authors: Martin Bachman; Santiago Uribe-Lewis; Xiaoping Yang; Michael Williams; Adele Murrell; Shankar Balasubramanian
Journal: Nat Chem Date: 2014-09-21 Impact factor: 24.427

9. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

Authors: Raajit Rampal; Altuna Alkalin; Jozef Madzo; Aparna Vasanthakumar; Elodie Pronier; Jay Patel; Yushan Li; Jihae Ahn; Omar Abdel-Wahab; Alan Shih; Chao Lu; Patrick S Ward; Jennifer J Tsai; Todd Hricik; Valeria Tosello; Jacob E Tallman; Xinyang Zhao; Danette Daniels; Qing Dai; Luisa Ciminio; Iannis Aifantis; Chuan He; Francois Fuks; Martin S Tallman; Adolfo Ferrando; Stephen Nimer; Elisabeth Paietta; Craig B Thompson; Jonathan D Licht; Christopher E Mason; Lucy A Godley; Ari Melnick; Maria E Figueroa; Ross L Levine
Journal: Cell Rep Date: 2014-12-04 Impact factor: 9.423

10. 5-Formylcytosine alters the structure of the DNA double helix.

Authors: Eun-Ang Raiber; Pierre Murat; Dimitri Y Chirgadze; Dario Beraldi; Ben F Luisi; Shankar Balasubramanian
Journal: Nat Struct Mol Biol Date: 2014-12-15 Impact factor: 15.369

36 in total

1. Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.

Authors: Fang Lu; Andreas Wiedmer; Kayla A Martin; Priyankara J M S Wickramasinghe; Andrew V Kossenkov; Paul M Lieberman
Journal: J Virol Date: 2017-09-27 Impact factor: 5.103

Review 2. Yin-yang actions of histone methylation regulatory complexes in the brain.

Authors: Patricia Marie Garay; Margarete Aryanka Wallner; Shigeki Iwase
Journal: Epigenomics Date: 2016-11-18 Impact factor: 4.778

Review 3. Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.

Authors: Chan-Wang J Lio; Hiroshi Yuita; Anjana Rao
Journal: Blood Date: 2019-10-31 Impact factor: 22.113

4. BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma.

Authors: Shoko Nishizawa; Mamiko Sakata-Yanagimoto; Keiichiro Hattori; Hideharu Muto; Tran Nguyen; Koji Izutsu; Kenichi Yoshida; Seishi Ogawa; Naoya Nakamura; Shigeru Chiba
Journal: Int J Hematol Date: 2016-12-05 Impact factor: 2.490

5. 5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4.

Authors: Syed Khund-Sayeed; Ximiao He; Timothy Holzberg; Jun Wang; Divya Rajagopal; Shriyash Upadhyay; Stewart R Durell; Sanjit Mukherjee; Matthew T Weirauch; Robert Rose; Charles Vinson
Journal: Integr Biol (Camb) Date: 2016-08-03 Impact factor: 2.192