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Literature DB >> 27480808

Are there specific readers of oxidized 5-methylcytosine bases?

Abstract

5-methylcytosine (5mC) was long thought to be the only enzymatically created modified DNA base in mammalian cells. The discovery of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine as reaction products of the TET family 5mC oxidases has prompted extensive searches for proteins that specifically bind to these oxidized bases. However, only a few of such "reader" proteins have been identified and verified so far. In this review, we discuss potential biological functions of oxidized 5mC as well as the role the presumed reader proteins may play in interpreting the genomic signals of 5mC oxidation products.

Entities: Chemical Disease Gene Mutation Species

Keywords: 5-carboxylcytosine; 5-formylcytosine; 5-hydroxymethylcytosine; 5-methylcytosine; TET proteins; chromatin readers

Mesh：

Substances：

Year: 2016 PMID： 27480808 PMCID： PMC5294966 DOI： 10.1002/bies.201600126

Source DB: PubMed Journal: Bioessays ISSN： 0265-9247 Impact factor: 4.345

104 in total

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Journal: Nature Date: 2011-12-14 Impact factor: 49.962

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Journal: Cell Date: 1989-08-11 Impact factor: 41.582

Review 4. DNA methylation and hydroxymethylation in hematologic differentiation and transformation.

Authors: Myunggon Ko; Jungeun An; Anjana Rao
Journal: Curr Opin Cell Biol Date: 2015-11-18 Impact factor: 8.382

5. Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.

Authors: Daniel Globisch; Martin Münzel; Markus Müller; Stylianos Michalakis; Mirko Wagner; Susanne Koch; Tobias Brückl; Martin Biel; Thomas Carell
Journal: PLoS One Date: 2010-12-23 Impact factor: 3.240

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Authors: Kathleen H Wood; Zhaolan Zhou
Journal: Front Genet Date: 2016-05-26 Impact factor: 4.599

7. Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.

Authors: Eun-Ang Raiber; Dario Beraldi; Gabriella Ficz; Heather E Burgess; Miguel R Branco; Pierre Murat; David Oxley; Michael J Booth; Wolf Reik; Shankar Balasubramanian
Journal: Genome Biol Date: 2012-08-17 Impact factor: 13.583

8. Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity.

Authors: Sergei Khrapunov; Christopher Warren; Huiyong Cheng; Esther R Berko; John M Greally; Michael Brenowitz
Journal: Biochemistry Date: 2014-05-23 Impact factor: 3.162

9. 5-Formylcytosine alters the structure of the DNA double helix.

Authors: Eun-Ang Raiber; Pierre Murat; Dimitri Y Chirgadze; Dario Beraldi; Ben F Luisi; Shankar Balasubramanian
Journal: Nat Struct Mol Biol Date: 2014-12-15 Impact factor: 15.369

10. Role of Tet proteins in enhancer activity and telomere elongation.

Authors: Falong Lu; Yuting Liu; Lan Jiang; Shinpei Yamaguchi; Yi Zhang
Journal: Genes Dev Date: 2014-09-15 Impact factor: 11.361

15 in total

1. Oxidized Derivatives of 5-Methylcytosine Alter the Stability and Dehybridization Dynamics of Duplex DNA.

Authors: Paul J Sanstead; Brennan Ashwood; Qing Dai; Chuan He; Andrei Tokmakoff
Journal: J Phys Chem B Date: 2020-02-05 Impact factor: 2.991

2. 5-hydroxymethylcytosine in DNA repair: A new player or a red herring?

Authors: Omar L Kantidze; Sergey V Razin
Journal: Cell Cycle Date: 2017-07-26 Impact factor: 4.534

3. Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting.

Authors: Iris Patiño-Parrado; Álvaro Gómez-Jiménez; Noelia López-Sánchez; José M Frade
Journal: Nucleic Acids Res Date: 2017-09-06 Impact factor: 16.971

4. Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression.

Authors: Ashley Ramsawhook; Lara Lewis; Beth Coyle; Alexey Ruzov
Journal: Clin Epigenetics Date: 2017-02-13 Impact factor: 6.551

5. Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification.

Authors: Lara C Lewis; Peggy Cho Kiu Lo; Jeremy M Foster; Nan Dai; Ivan R Corrêa; Paulina M Durczak; Gary Duncan; Ashley Ramsawhook; Guruprasad Padur Aithal; Chris Denning; Nicholas R F Hannan; Alexey Ruzov
Journal: Epigenetics Date: 2017-03-07 Impact factor: 4.528