Literature DB >> 27105138

RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications.

Ji Hyun Shin1, Liang Xu1, Dong Wang1.   

Abstract

During transcription elongation, RNA polymerase II (pol II) travels along the DNA template across thousands to millions of nucleotides and accurately synthesizes the complementary RNA transcripts. Apart from its canonical function as a key enzyme for DNA-dependent RNA synthesis, pol II also functions as a selective sensor to recognize DNA lesions or epigenetic modifications.

Keywords:  DNA lesions; DNA modifications; RNA polymerase II; epi-DNA recognition loop; sensor

Mesh：

Substances：

Year:  2016        PMID： 27105138      PMCID： PMC4984683          DOI： 10.1080/21541264.2016.1168506

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  34 in total

1.  The role of DNA methylation in mammalian epigenetics.

Authors:  P A Jones; D Takai
Journal:  Science       Date:  2001-08-10       Impact factor: 47.728

2.  Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage.

Authors:  Celine Walmacq; Alan C M Cheung; Maria L Kireeva; Lucyna Lubkowska; Chengcheng Ye; Deanna Gotte; Jeffrey N Strathern; Thomas Carell; Patrick Cramer; Mikhail Kashlev
Journal:  Mol Cell       Date:  2012-03-08       Impact factor: 17.970

3.  Transient reversal of RNA polymerase II active site closing controls fidelity of transcription elongation.

Authors:  Maria L Kireeva; Yuri A Nedialkov; Gina H Cremona; Yuri A Purtov; Lucyna Lubkowska; Francisco Malagon; Zachary F Burton; Jeffrey N Strathern; Mikhail Kashlev
Journal:  Mol Cell       Date:  2008-06-06       Impact factor: 17.970

4.  Millisecond dynamics of RNA polymerase II translocation at atomic resolution.

Authors:  Daniel-Adriano Silva; Dahlia R Weiss; Fátima Pardo Avila; Lin-Tai Da; Michael Levitt; Dong Wang; Xuhui Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-21       Impact factor: 11.205

Review 5.  RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.

Authors:  Liang Xu; Wei Wang; Jenny Chong; Ji Hyun Shin; Jun Xu; Dong Wang
Journal:  Crit Rev Biochem Mol Biol       Date:  2015-09-22       Impact factor: 8.250

6.  Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

Authors:  Henri G A M van Luenen; Carol Farris; Sabrina Jan; Paul-Andre Genest; Pankaj Tripathi; Arno Velds; Ron M Kerkhoven; Marja Nieuwland; Andrew Haydock; Gowthaman Ramasamy; Saara Vainio; Tatjana Heidebrecht; Anastassis Perrakis; Ludo Pagie; Bas van Steensel; Peter J Myler; Piet Borst
Journal:  Cell       Date:  2012-08-31       Impact factor: 41.582

7.  DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å.

Authors:  Yiwei Liu; Yusuf Olatunde Olanrewaju; Xing Zhang; Xiaodong Cheng
Journal:  Biochemistry       Date:  2013-11-20       Impact factor: 3.162

8.  Rpb9 subunit controls transcription fidelity by delaying NTP sequestration in RNA polymerase II.

Authors:  Celine Walmacq; Maria L Kireeva; Jordan Irvin; Yuri Nedialkov; Lucyna Lubkowska; Francisco Malagon; Jeffrey N Strathern; Mikhail Kashlev
Journal:  J Biol Chem       Date:  2009-05-13       Impact factor: 5.157

Review 9.  Transcription-coupled DNA repair: two decades of progress and surprises.

Authors:  Philip C Hanawalt; Graciela Spivak
Journal:  Nat Rev Mol Cell Biol       Date:  2008-12       Impact factor: 94.444

10.  5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription.

Authors:  Matthew W Kellinger; Chun-Xiao Song; Jenny Chong; Xing-Yu Lu; Chuan He; Dong Wang
Journal:  Nat Struct Mol Biol       Date:  2012-07-22       Impact factor: 15.369
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  8 in total

1.  Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis.

Authors:  Liang Xu; Wei Wang; Jiabin Wu; Ji Hyun Shin; Pengcheng Wang; Ilona Christy Unarta; Jenny Chong; Yinsheng Wang; Dong Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-07       Impact factor: 11.205

Review 2.  Structural and biochemical analysis of DNA lesion-induced RNA polymerase II arrest.

Authors:  Juntaek Oh; Jun Xu; Jenny Chong; Dong Wang
Journal:  Methods       Date:  2019-02-22       Impact factor: 3.608

3.  Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing.

Authors:  Wei Wang; Liang Xu; Lulu Hu; Jenny Chong; Chuan He; Dong Wang
Journal:  J Am Chem Soc       Date:  2017-10-03       Impact factor: 15.419

4.  The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.

Authors:  Marina Kolbanovskiy; Moinuddin A Chowdhury; Aditi Nadkarni; Suse Broyde; Nicholas E Geacintov; David A Scicchitano; Vladimir Shafirovich
Journal:  Biochemistry       Date:  2017-06-07       Impact factor: 3.162

5.  Mechanism of RNA polymerase II stalling by DNA alkylation.

Authors:  Stefano Malvezzi; Lucas Farnung; Claudia M N Aloisi; Todor Angelov; Patrick Cramer; Shana J Sturla
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-30       Impact factor: 11.205

6.  FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.

Authors:  Franziska Wienholz; Di Zhou; Yasemin Turkyilmaz; Petra Schwertman; Maria Tresini; Alex Pines; Marvin van Toorn; Karel Bezstarosti; Jeroen A A Demmers; Jurgen A Marteijn
Journal:  Nucleic Acids Res       Date:  2019-05-07       Impact factor: 16.971

7.  Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members.

Authors:  Elena Gonzalo-Gil; Patrick B Rapuano; Uchenna Ikediobi; Rebecca Leibowitz; Sameet Mehta; Ayse K Coskun; J Zachary Porterfield; Teagan D Lampkin; Vincent C Marconi; David Rimland; Bruce D Walker; Steven Deeks; Richard E Sutton
Journal:  Elife       Date:  2019-04-09       Impact factor: 8.140

8.  RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.

Authors:  Juntaek Oh; Tiezheng Jia; Jun Xu; Jenny Chong; Peter B Dervan; Dong Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2022-01-18       Impact factor: 11.205
  8 in total

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