Literature DB >> 26067001

Incorporating Sex as a Variable in Preclinical Neuropsychiatric Research.

Margaret M McCarthy1.   

Abstract

In an effort to increase applicability of preclinical research to both men and women, the National Institute of Health is anticipated to put forth guidelines for the incorporation of sex as a variable in animal studies. Common myths and perceived barriers to the inclusion of females in neuroscience research are discussed and a roadmap for implementation provided. Accounting for sex as a variable does not require studying sex differences and is easier to implement than generally assumed.
© The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  behavior; hormones; sex differences

Mesh:

Year:  2015        PMID: 26067001      PMCID: PMC4535645          DOI: 10.1093/schbul/sbv077

Source DB:  PubMed          Journal:  Schizophr Bull        ISSN: 0586-7614            Impact factor:   9.306


  34 in total

1.  Males still dominate animal studies.

Authors:  Irving Zucker; Annaliese K Beery
Journal:  Nature       Date:  2010-06-10       Impact factor: 49.962

Review 2.  Strategies and methods for research on sex differences in brain and behavior.

Authors:  Jill B Becker; Arthur P Arnold; Karen J Berkley; Jeffrey D Blaustein; Lisa A Eckel; Elizabeth Hampson; James P Herman; Sherry Marts; Wolfgang Sadee; Meir Steiner; Jane Taylor; Elizabeth Young
Journal:  Endocrinology       Date:  2004-12-23       Impact factor: 4.736

Review 3.  Sex and gender differences in pain and analgesia.

Authors:  Jeffrey S Mogil; Andrea L Bailey
Journal:  Prog Brain Res       Date:  2010       Impact factor: 2.453

4.  Animals have a sex, and so should titles and methods sections of articles in Endocrinology.

Authors:  Jeffrey D Blaustein
Journal:  Endocrinology       Date:  2012-06       Impact factor: 4.736

5.  Female mice liberated for inclusion in neuroscience and biomedical research.

Authors:  Brian J Prendergast; Kenneth G Onishi; Irving Zucker
Journal:  Neurosci Biobehav Rev       Date:  2014-01-20       Impact factor: 8.989

6.  Policy: NIH to balance sex in cell and animal studies.

Authors:  Janine A Clayton; Francis S Collins
Journal:  Nature       Date:  2014-05-15       Impact factor: 49.962

7.  Novel PCR assay for determining the genetic sex of mice.

Authors:  L McFarlane; V Truong; J S Palmer; D Wilhelm
Journal:  Sex Dev       Date:  2013-04-04       Impact factor: 1.824

Review 8.  What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues?

Authors:  Arthur P Arnold; Xuqi Chen
Journal:  Front Neuroendocrinol       Date:  2008-11-11       Impact factor: 8.606

9.  Policy: NIH plans to enhance reproducibility.

Authors:  Francis S Collins; Lawrence A Tabak
Journal:  Nature       Date:  2014-01-30       Impact factor: 49.962

Review 10.  NIH initiative to balance sex of animals in preclinical studies: generative questions to guide policy, implementation, and metrics.

Authors:  Louise D McCullough; Geert J de Vries; Virginia M Miller; Jill B Becker; Kathryn Sandberg; Margaret M McCarthy
Journal:  Biol Sex Differ       Date:  2014-10-03       Impact factor: 5.027

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  19 in total

Review 1.  Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding.

Authors:  Gabriella M Mamlouk; David M Dorris; Lily R Barrett; John Meitzen
Journal:  Front Neuroendocrinol       Date:  2020-02-15       Impact factor: 8.606

2.  Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research.

Authors:  Rebecca M Shansky; Catherine S Woolley
Journal:  J Neurosci       Date:  2016-11-23       Impact factor: 6.167

Review 3.  Sex bias in preclinical research and an exploration of how to change the status quo.

Authors:  Natasha A Karp; Neil Reavey
Journal:  Br J Pharmacol       Date:  2018-12-12       Impact factor: 8.739

Review 4.  Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies.

Authors:  Marina Guizzetti; Daryl L Davies; Mark Egli; Deborah A Finn; Patricia Molina; Soundar Regunathan; Donita L Robinson; Farida Sohrabji
Journal:  Alcohol Clin Exp Res       Date:  2016-05-07       Impact factor: 3.455

5.  Incorporating Sex As a Biological Variable in Neuropsychiatric Research: Where Are We Now and Where Should We Be?

Authors:  Daphna Joel; Margaret M McCarthy
Journal:  Neuropsychopharmacology       Date:  2016-05-31       Impact factor: 7.853

6.  Exposure to acute stress enhances decision-making competence: Evidence for the role of DHEA.

Authors:  Grant S Shields; Jovian C W Lam; Brian C Trainor; Andrew P Yonelinas
Journal:  Psychoneuroendocrinology       Date:  2016-02-03       Impact factor: 4.905

7.  Effects of Withdrawal from Chronic Intermittent Ethanol Exposure on Sleep Characteristics of Female and Male Mice.

Authors:  Salvador Huitron-Resendiz; Tali Nadav; Stephanie Krause; Chelsea Cates-Gatto; Ilham Polis; Amanda J Roberts
Journal:  Alcohol Clin Exp Res       Date:  2018-01-30       Impact factor: 3.455

Review 8.  Why estrogens matter for behavior and brain health.

Authors:  Liisa A M Galea; Karyn M Frick; Elizabeth Hampson; Farida Sohrabji; Elena Choleris
Journal:  Neurosci Biobehav Rev       Date:  2016-03-31       Impact factor: 8.989

9.  Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.

Authors:  Emilie I Petit; Zuzanna Michalak; Rachel Cox; Colm M P O'Tuathaigh; Niamh Clarke; Orna Tighe; Konrad Talbot; Derek Blake; Josephine Joel; Alexander Shaw; Steven A Sheardown; Alastair D Morrison; Stephen Wilson; Ellen M Shapland; David C Henshall; James N Kew; Brian P Kirby; John L Waddington
Journal:  Neuropsychopharmacology       Date:  2016-12-16       Impact factor: 7.853

10.  Characterization of Glycosaminoglycan Disaccharide Composition in Astrocyte Primary Cultures and the Cortex of Neonatal Rats.

Authors:  Xiaolu Zhang; Joel G Hashimoto; Xiaorui Han; Fuming Zhang; Robert J Linhardt; Marina Guizzetti
Journal:  Neurochem Res       Date:  2021-01-04       Impact factor: 4.414

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