Literature DB >> 32070715

Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding.

Gabriella M Mamlouk1, David M Dorris1, Lily R Barrett2, John Meitzen3.   

Abstract

Neuroscience research has historically demonstrated sex bias that favors male over female research subjects, as well as sex omission, which is the lack of reporting sex. Here we analyzed the status of sex bias and omission in neuroscience research published across six different journals in 2017. Regarding sex omission, 16% of articles did not report sex. Regarding sex bias, 52% of neuroscience articles reported using both males and females, albeit only 15% of articles using both males and females reported assessing sex as an experimental variable. Overrepresentation of the sole use of males compared to females persisted (26% versus 5%, respectively). Sex bias and omission differed across research models, but not by reported NIH funding status. Sex omission differed across journals. These findings represent the latest information regarding the complex status of sex in neuroscience research and illustrate the continued need for thoughtful and informed action to enhance scientific discovery.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Female; Male; Neuroscience; Sex bias; Sex difference; Sex omission; Sex reporting; Women’s health

Mesh:

Year:  2020        PMID: 32070715      PMCID: PMC7225067          DOI: 10.1016/j.yfrne.2020.100835

Source DB:  PubMed          Journal:  Front Neuroendocrinol        ISSN: 0091-3022            Impact factor:   8.606


  102 in total

Review 1.  Perils and pitfalls of reporting sex differences.

Authors:  Donna L Maney
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-02-01       Impact factor: 6.237

2.  Latent Sex Differences in Molecular Signaling That Underlies Excitatory Synaptic Potentiation in the Hippocampus.

Authors:  Anant Jain; Guang Zhe Huang; Catherine S Woolley
Journal:  J Neurosci       Date:  2018-12-21       Impact factor: 6.167

3.  Opinion: Sex inclusion in basic research drives discovery.

Authors:  Sabra L Klein; Londa Schiebinger; Marcia L Stefanick; Larry Cahill; Jayne Danska; Geert J de Vries; Melina R Kibbe; Margaret M McCarthy; Jeffrey S Mogil; Teresa K Woodruff; Irving Zucker
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-20       Impact factor: 11.205

4.  One and a half million medical papers reveal a link between author gender and attention to gender and sex analysis.

Authors:  Mathias Wullum Nielsen; Jens Peter Andersen; Londa Schiebinger; Jesper W Schneider
Journal:  Nat Hum Behav       Date:  2017-11-06

5.  Perspective: Equality need not be painful.

Authors:  Jeffrey S Mogil
Journal:  Nature       Date:  2016-07-14       Impact factor: 49.962

Review 6.  Understanding the broad influence of sex hormones and sex differences in the brain.

Authors:  Bruce S McEwen; Teresa A Milner
Journal:  J Neurosci Res       Date:  2017-01-02       Impact factor: 4.164

7.  Problems and Progress regarding Sex Bias and Omission in Neuroscience Research.

Authors:  Tyler R Will; Stephanie B Proaño; Anly M Thomas; Lindsey M Kunz; Kelly C Thompson; Laura A Ginnari; Clay H Jones; Sarah-Catherine Lucas; Elizabeth M Reavis; David M Dorris; John Meitzen
Journal:  eNeuro       Date:  2017-11-09

Review 8.  Biological Sex, Estradiol and Striatal Medium Spiny Neuron Physiology: A Mini-Review.

Authors:  Amanda A Krentzel; John Meitzen
Journal:  Front Cell Neurosci       Date:  2018-12-12       Impact factor: 5.505

9.  Female rats are not more variable than male rats: a meta-analysis of neuroscience studies.

Authors:  Jill B Becker; Brian J Prendergast; Jing W Liang
Journal:  Biol Sex Differ       Date:  2016-07-26       Impact factor: 5.027

Review 10.  Sex and Gender Equity in Research: rationale for the SAGER guidelines and recommended use.

Authors:  Shirin Heidari; Thomas F Babor; Paola De Castro; Sera Tort; Mirjam Curno
Journal:  Res Integr Peer Rev       Date:  2016-05-03
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  17 in total

Review 1.  Demographic reporting across a decade of neuroimaging: a systematic review.

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Journal:  Brain Imaging Behav       Date:  2022-09-17       Impact factor: 3.224

Review 2.  Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases.

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Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

Review 3.  Animal models built for women's brain health: Progress and potential.

Authors:  Kathleen E Morrison
Journal:  Front Neuroendocrinol       Date:  2020-09-19       Impact factor: 8.606

4.  Studying Sex Differences in Rodent Models of Addictive Behavior.

Authors:  Anna K Radke; Elizabeth A Sneddon; Sean C Monroe
Journal:  Curr Protoc       Date:  2021-04

Review 5.  Sex is a defining feature of neuroimaging phenotypes in major brain disorders.

Authors:  Lauren E Salminen; Meral A Tubi; Joanna Bright; Sophia I Thomopoulos; Alyssa Wieand; Paul M Thompson
Journal:  Hum Brain Mapp       Date:  2021-05-05       Impact factor: 5.038

Review 6.  The estrous cycle and 17β-estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons.

Authors:  Amanda A Krentzel; Stephanie B Proaño; David M Dorris; Beverly Setzer; John Meitzen
Journal:  J Neuroendocrinol       Date:  2022-04-02       Impact factor: 3.870

7.  An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences.

Authors:  Rebecca K Rechlin; Tallinn F L Splinter; Travis E Hodges; Arianne Y Albert; Liisa A M Galea
Journal:  Nat Commun       Date:  2022-04-19       Impact factor: 17.694

Review 8.  Sex differences in pain along the neuraxis.

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Journal:  Neuropharmacology       Date:  2022-03-21       Impact factor: 5.273

9.  Large-scale labeling and assessment of sex bias in publicly available expression data.

Authors:  Emily Flynn; Annie Chang; Russ B Altman
Journal:  BMC Bioinformatics       Date:  2021-03-30       Impact factor: 3.169

10.  A 10-year follow-up study of sex inclusion in the biological sciences.

Authors:  Nicole C Woitowich; Annaliese Beery; Teresa Woodruff
Journal:  Elife       Date:  2020-06-09       Impact factor: 8.140

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