OBJECTIVES: The purpose of this study was to investigate the usefulness of T1W black-blood Cube (BB Cube) and T1W BB Cube fluid-attenuated inversion recovery (BB Cube-FLAIR) sequences for contrast-enhanced brain imaging, by evaluating flow-related artefacts, detectability, and contrast ratio (CR) of intracranial lesions among these sequences and T1W-SE. METHODS: Phantom studies were performed to determine the optimal parameters of BB Cube and BB Cube-FLAIR. A clinical study in 23 patients with intracranial lesions was performed to evaluate the usefulness of these two sequences for the diagnosis of intracranial lesions compared with the conventional 2D T1W-SE sequence. RESULTS: The phantom study revealed that the optimal parameters for contrast-enhanced T1W imaging were TR/TE = 500 ms/minimum in BB Cube and TR/TE/TI = 600 ms/minimum/300 ms in BB Cube-FLAIR imaging. In the clinical study, the degree of flow-related artefacts was significantly lower in BB Cube and BB Cube-FLAIR than in T1W-SE. Regarding tumour detection, BB Cube showed the best detectability; however, there were no significant differences in CR among the sequences. CONCLUSIONS: At 1.5 T, contrast-enhanced BB Cube was a better imaging sequence for detecting brain lesions than T1W-SE or BB Cube-FLAIR. KEY POINTS: • Cube is a single-slab 3D FSE imaging sequence. • We applied a black-blood (BB) imaging technique to T1W Cube. • At 1.5 T, contrast-enhanced T1W BB Cube was valuable for detecting brain lesions.
OBJECTIVES: The purpose of this study was to investigate the usefulness of T1W black-blood Cube (BB Cube) and T1W BB Cube fluid-attenuated inversion recovery (BB Cube-FLAIR) sequences for contrast-enhanced brain imaging, by evaluating flow-related artefacts, detectability, and contrast ratio (CR) of intracranial lesions among these sequences and T1W-SE. METHODS: Phantom studies were performed to determine the optimal parameters of BB Cube and BB Cube-FLAIR. A clinical study in 23 patients with intracranial lesions was performed to evaluate the usefulness of these two sequences for the diagnosis of intracranial lesions compared with the conventional 2D T1W-SE sequence. RESULTS: The phantom study revealed that the optimal parameters for contrast-enhanced T1W imaging were TR/TE = 500 ms/minimum in BB Cube and TR/TE/TI = 600 ms/minimum/300 ms in BB Cube-FLAIR imaging. In the clinical study, the degree of flow-related artefacts was significantly lower in BB Cube and BB Cube-FLAIR than in T1W-SE. Regarding tumour detection, BB Cube showed the best detectability; however, there were no significant differences in CR among the sequences. CONCLUSIONS: At 1.5 T, contrast-enhanced BB Cube was a better imaging sequence for detecting brain lesions than T1W-SE or BB Cube-FLAIR. KEY POINTS: • Cube is a single-slab 3D FSE imaging sequence. • We applied a black-blood (BB) imaging technique to T1W Cube. • At 1.5 T, contrast-enhanced T1W BB Cube was valuable for detecting brain lesions.
Entities:
Keywords:
3D fast spin-echo (FSE); Contrast enhancement; Cube; Magnetic resonance imaging; black-blood (BB) imaging
Authors: Christian Thaler; Tanja Schneider; Jan Sedlacik; Daniel Kutzner; Jan-Patrick Stellmann; Christoph Heesen; Jens Fiehler; Susanne Siemonsen Journal: PLoS One Date: 2017-08-10 Impact factor: 3.240