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Literature DB >> 25929681

Cucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent.

Abstract

A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized (129)Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] binding.

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Year: 2015 PMID： 25929681 PMCID： PMC4433404 DOI： 10.1039/c5cc01826a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

37 in total

1. Analytical solution for the depolarization of hyperpolarized nuclei by chemical exchange saturation transfer between free and encapsulated xenon (HyperCEST).

Authors: Moritz Zaiss; Matthias Schnurr; Peter Bachert
Journal: J Chem Phys Date: 2012-04-14 Impact factor: 3.488

2. Cucurbit[n]urils: from mechanism to structure and function.

Authors: Lyle Isaacs
Journal: Chem Commun (Camb) Date: 2008-11-27 Impact factor: 6.222

3. Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations.

Authors: Honor M Rose; Christopher Witte; Federica Rossella; Stefan Klippel; Christian Freund; Leif Schröder
Journal: Proc Natl Acad Sci U S A Date: 2014-07-28 Impact factor: 11.205

4. Brain endothelial cell targeting via a peptide-functionalized liposomal carrier for xenon hyper-CEST MRI.

Authors: Matthias Schnurr; Karl Sydow; Honor May Rose; Margitta Dathe; Leif Schröder
Journal: Adv Healthc Mater Date: 2014-07-01 Impact factor: 9.933

5. Biological magnetic resonance imaging using laser-polarized 129Xe.

Authors: M S Albert; G D Cates; B Driehuys; W Happer; B Saam; C S Springer; A Wishnia
Journal: Nature Date: 1994-07-21 Impact factor: 49.962

6. Nanoemulsion contrast agents with sub-picomolar sensitivity for xenon NMR.

Authors: Todd K Stevens; R Matthew Ramirez; Alexander Pines
Journal: J Am Chem Soc Date: 2013-06-18 Impact factor: 15.419

7. Shorter synthesis of trifunctionalized cryptophane-A derivatives.

Authors: Olena Taratula; P Aru Hill; Yubin Bai; Najat S Khan; Ivan J Dmochowski
Journal: Org Lett Date: 2011-02-18 Impact factor: 6.005

8. A water-soluble Xe@cryptophane-111 complex exhibits very high thermodynamic stability and a peculiar (129)Xe NMR chemical shift.

Authors: Robert M Fairchild; Akil I Joseph; K Travis Holman; Heather A Fogarty; Thierry Brotin; Jean-Pierre Dutasta; Céline Boutin; Gaspard Huber; Patrick Berthault
Journal: J Am Chem Soc Date: 2010-11-10 Impact factor: 15.419

9. Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase.

Authors: Jennifer M Chambers; P Aru Hill; Julie A Aaron; Zhaohui Han; David W Christianson; Nicholas N Kuzma; Ivan J Dmochowski
Journal: J Am Chem Soc Date: 2009-01-21 Impact factor: 15.419

10. Crystallographic observation of 'induced fit' in a cryptophane host-guest model system.

Authors: Olena Taratula; P Aru Hill; Najat S Khan; Patrick J Carroll; Ivan J Dmochowski
Journal: Nat Commun Date: 2010-12-21 Impact factor: 14.919

23 in total

1. Programming A Molecular Relay for Ultrasensitive Biodetection through (129)Xe NMR.

Authors: Yanfei Wang; Benjamin W Roose; John P Philbin; Jordan L Doman; Ivan J Dmochowski
Journal: Angew Chem Int Ed Engl Date: 2015-12-21 Impact factor: 15.336

2. A Genetically Encoded β-Lactamase Reporter for Ultrasensitive (129) Xe NMR in Mammalian Cells.

Authors: Yanfei Wang; Benjamin W Roose; Eugene J Palovcak; Vincenzo Carnevale; Ivan J Dmochowski
Journal: Angew Chem Int Ed Engl Date: 2016-06-15 Impact factor: 15.336

3. A Structural Basis for ¹²⁹ Xe Hyper-CEST Signal in TEM-1 β-Lactamase.

Authors: Benjamin W Roose; Serge D Zemerov; Yanfei Wang; Marina A Kasimova; Vincenzo Carnevale; Ivan J Dmochowski
Journal: Chemphyschem Date: 2018-09-13 Impact factor: 3.102

4. Cryptophane Nanoscale Assemblies Expand ¹²⁹Xe NMR Biosensing.

Authors: Serge D Zemerov; Benjamin W Roose; Mara L Greenberg; Yanfei Wang; Ivan J Dmochowski
Journal: Anal Chem Date: 2018-06-01 Impact factor: 6.986

5. Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.

Authors: Nicola J Rogers; Fraser Hill-Casey; Karl F Stupic; Joseph S Six; Clémentine Lesbats; Sean P Rigby; Jacques Fraissard; Galina E Pavlovskaya; Thomas Meersmann
Journal: Proc Natl Acad Sci U S A Date: 2016-03-09 Impact factor: 11.205

6. Directly Functionalized Cucurbit[7]uril as a Biosensor for the Selective Detection of Protein Interactions by ¹²⁹ Xe hyperCEST NMR.

Authors: Ashley E Truxal; Liping Cao; Lyle Isaacs; David E Wemmer; Alexander Pines
Journal: Chemistry Date: 2019-03-29 Impact factor: 5.236