Literature DB >> 2582354

The gene for an exported antigen of the malaria parasite Plasmodium falciparum cloned and expressed in Escherichia coli.

I A Hope, M Mackay, J E Hyde, M Goman, J Scaife.   

Abstract

An exported protein of the erythrocytic stages of the malaria parasite, Plasmodium falciparum, has epitope(s) in common with the surface of the sporozoite stage (1). Two cDNA clones encoding this protein, Ag5.1, have now been isolated and expressed in Escherichia coli. The coding sequence contains a region with strong homology to that of the circumsporozoite protein of P. falciparum. Other features of the sequence can be explained in terms of the observed behaviour of the protein in the parasite life cycle. The Ag5.1 can now be synthesised in bacteria in sufficient amounts to analyse the immune response to this protein.

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Year:  1985        PMID： 2582354      PMCID： PMC341001          DOI： 10.1093/nar/13.2.369

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  20 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Antigenic diversity in the human malaria parasite Plasmodium falciparum.

Authors:  J S McBride; D Walliker; G Morgan
Journal:  Science       Date:  1982-07-16       Impact factor: 47.728

4.  Efficient isolation of genes by using antibody probes.

Authors:  R A Young; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

5.  A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.

Authors:  J Messing; J Vieira
Journal:  Gene       Date:  1982-10       Impact factor: 3.688

6.  Characterization of translational initiation sites in E. coli.

Authors:  G D Stormo; T D Schneider; L M Gold
Journal:  Nucleic Acids Res       Date:  1982-05-11       Impact factor: 16.971

7.  Resistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests.

Authors:  S Thaithong; G H Beale
Journal:  Trans R Soc Trop Med Hyg       Date:  1981       Impact factor: 2.184

8.  Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria.

Authors:  R Hall; J E Hyde; M Goman; D L Simmons; I A Hope; M Mackay; J Scaife; B Merkli; R Richle; J Stocker
Journal:  Nature       Date:  1984 Sep 27-Oct 3       Impact factor: 49.962

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

Review 10.  Mechanisms for the incorporation of proteins in membranes and organelles.

Authors:  D D Sabatini; G Kreibich; T Morimoto; M Adesnik
Journal:  J Cell Biol       Date:  1982-01       Impact factor: 10.539
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  15 in total

Review 1.  Class I HLA-restricted cytotoxic T lymphocyte responses against malaria--elucidation on the basis of HLA peptide binding motifs.

Authors:  D L Doolan; B Wizel; S L Hoffman
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829

2.  An asparagine-rich protein from blood stages of Plasmodium falciparum shares determinants with sporozoites.

Authors:  H D Stahl; A E Bianco; P E Crewther; T Burkot; R L Coppel; G V Brown; R F Anders; D J Kemp
Journal:  Nucleic Acids Res       Date:  1986-04-11       Impact factor: 16.971

3.  Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Authors:  Andreas Martin Lisewski; Joel P Quiros; Caroline L Ng; Anbu Karani Adikesavan; Kazutoyo Miura; Nagireddy Putluri; Richard T Eastman; Daniel Scanfeld; Sam J Regenbogen; Lindsey Altenhofen; Manuel Llinás; Arun Sreekumar; Carole Long; David A Fidock; Olivier Lichtarge
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582

4.  Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

Authors:  Cláudia Sá E Cunha; Britta Nyboer; Kirsten Heiss; Margarida Sanches-Vaz; Diana Fontinha; Ellen Wiedtke; Dirk Grimm; Jude Marek Przyborski; Maria M Mota; Miguel Prudêncio; Ann-Kristin Mueller
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-30       Impact factor: 11.205

5.  EXP1 is required for organisation of EXP2 in the intraerythrocytic malaria parasite vacuole.

Authors:  Timothy Nessel; John M Beck; Shima Rayatpisheh; Yasaman Jami-Alahmadi; James A Wohlschlegel; Daniel E Goldberg; Josh R Beck
Journal:  Cell Microbiol       Date:  2020-02-12       Impact factor: 3.715

6.  A blood stage antigen of Plasmodium falciparum shares determinants with the sporozoite coat protein.

Authors:  R L Coppel; J M Favaloro; P E Crewther; T R Burkot; A E Bianco; H D Stahl; D J Kemp; R F Anders; G V Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

7.  Variation in the gene encoding a major merozoite surface antigen of the human malaria parasite Plasmodium falciparum.

Authors:  J L Weber; W M Leininger; J A Lyon
Journal:  Nucleic Acids Res       Date:  1986-04-25       Impact factor: 16.971

8.  Identification of two integral membrane proteins of Plasmodium falciparum.

Authors:  J A Smythe; R L Coppel; G V Brown; R Ramasamy; D J Kemp; R F Anders
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

9.  Detection of human antibodies against Plasmodium falciparum sporozoites using synthetic peptides.

Authors:  G Del Giudice; A S Verdini; M Pinori; A Pessi; J P Verhave; C Tougne; B Ivanoff; P H Lambert; H D Engers
Journal:  J Clin Microbiol       Date:  1987-01       Impact factor: 5.948

10.  Plasmodium antigens external to the parasite but with the infected erythrocyte.

Authors:  M F Wiser
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289
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