Literature DB >> 2563939

Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice.

Y Nagata1, R Konno, Y Yasumura, T Akino.   

Abstract

The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.

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Year:  1989        PMID： 2563939      PMCID： PMC1135571          DOI： 10.1042/bj2570291

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  ALANINE: CYCLOSERINE ANTAGONISM. VI. DEMONSTRATION OF D-ALANINE IN THE SERUM OF GUINEA PIGS AND MICE.

Authors:  P D HOEPRICH
Journal:  J Biol Chem       Date:  1965-04       Impact factor: 5.157

2.  Flavin enzymes in liver and kidney of rats from birth to weaning.

Authors:  H B BURCH; O H LOWRY; T DE GUBAREFF; S R LOWRY
Journal:  J Cell Comp Physiol       Date:  1958-12

3.  D-amino acid oxidase in mouse liver.

Authors:  Y Nagata; T Akino
Journal:  Comp Biochem Physiol B       Date:  1988

4.  D-valine as a selective agent for normal human and rodent epithelial cells in culture.

Authors:  S F Gilbert; B R Migeon
Journal:  Cell       Date:  1975-05       Impact factor: 41.582

5.  Reactions of cysteamine and other amine metabolites with glyoxylate and oxygen catalyzed by mammalian D-amino acid oxidase.

Authors:  G A Hamilton; D J Buckthal; R M Mortensen; K W Zerby
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

6.  Microdetermination of serum D-amino acids.

Authors:  Y Nagata; T Akino; K Ohno
Journal:  Anal Biochem       Date:  1985-10       Impact factor: 3.365

7.  Thiazolidine-2-carboxylic acid, an adduct of cysteamine and glyoxylate, as a substrate for D-amino acid oxidase.

Authors:  P F Fitzpatrick; V Massey
Journal:  J Biol Chem       Date:  1982-02-10       Impact factor: 5.157

8.  Brain and kidney D-amino acid oxidases are coded by a single gene in the mouse.

Authors:  R Konno; Y Yasumura
Journal:  J Neurochem       Date:  1984-02       Impact factor: 5.372

9.  Free D-amino acids in human plasma in relation to senescence and renal diseases.

Authors:  Y Nagata; T Akino; K Ohno; Y Kataoka; T Ueda; T Sakurai; K Shiroshita; T Yasuda
Journal:  Clin Sci (Lond)       Date:  1987-07       Impact factor: 6.124

10.  Mouse mutant deficient in D-amino acid oxidase activity.

Authors:  R Konno; Y Yasumura
Journal:  Genetics       Date:  1983-02       Impact factor: 4.562
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  13 in total

1.  Purification of serine racemase: biosynthesis of the neuromodulator D-serine.

Authors:  H Wolosker; K N Sheth; M Takahashi; J P Mothet; R O Brady; C D Ferris; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

2.  Spontaneous excretion of D-alanine in urine in mutant mice lacking D-amino-acid oxidase.

Authors:  R Konno; Y Nagata; A Niwa; Y Yasumura
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857

3.  Administration of D-alanine did not cause increase of D-amino acid oxidase activity in mice.

Authors:  Y Nagata; R Yamada; H Nagasaki; R Konno; Y Yasumura
Journal:  Experientia       Date:  1991-08-15

4.  Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain.

Authors:  Y Nagata
Journal:  Experientia       Date:  1992-08-15

5.  Factors controlling the level and determination of D-amino acids in the urine and plasma of laboratory rodents.

Authors:  D W Armstrong; M P Gasper; S H Lee; N Ercal; J Zukowski
Journal:  Amino Acids       Date:  1993-06       Impact factor: 3.520

6.  A trial to determine D-amino acids in tissue proteins of mice.

Authors:  Y Nagata; K Kubota
Journal:  Amino Acids       Date:  1993-02       Impact factor: 3.520

7.  D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan.

Authors:  Linh P Nguyen; Erin L Hsu; Goutam Chowdhury; Miroslav Dostalek; F Peter Guengerich; Christopher A Bradfield
Journal:  Chem Res Toxicol       Date:  2009-12       Impact factor: 3.739

8.  The presence of free D-serine, D-alanine and D-proline in human plasma.

Authors:  Y Nagata; R Masui; T Akino
Journal:  Experientia       Date:  1992-10-15

Review 9.  The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspective.

Authors:  Michael J Schell
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2004-06-29       Impact factor: 6.237

10.  D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.

Authors:  M J Schell; M E Molliver; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205
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