PURPOSE: To evaluate the impact of iterative reconstruction on the detectability of clots. METHODS AND MATERIALS: Fifty-three patients were enrolled in a study comparing reduced-dose and full-dose images, available from the same dual-source data set. From each acquisition, three series of images were generated: (1) full-dose images (from both tubes), reconstructed with filtered back projection (FBP) (group 1; standard of reference), (2) reduced-dose images (from tube A only; 60 % dose reduction) reconstructed with FBP (group 2) and iterative reconstruction (SAFIRE) (group 3). RESULTS: In group 1 (mean DLP: 264.6 mGy.cm), (1) PE was diagnosed in 8 patients (15 %) with 82 clots in the central (n = 5), segmental (n = 39) and subsegmental (n = 38) arteries and (2) mean level of noise was 30.56 ± 5.07. In group 2 (mean DLP: 105.8 mGy.cm), a significant increase in noise (44.56 ± 6.24; p < 0.0001) (1) hampered detection of PE in one patient and (2) altered detection of peripheral clots (12 false-negative and 2 false-positive results). In group 3, image noise was not significantly different from that in group 1 (p = 0.1525; effect size: 0.2683), with a similar detection of PE compared to group 1 (p = 1). CONCLUSION: Reconstruction of reduced-dose images (60 % dose reduction) with SAFIRE provided image quality and diagnostic value comparable to those of full-dose FBP images. KEY POINTS: • Iterative reconstruction does not alter the detection of endoluminal clots. • Iterative reconstruction allows dose reduction in the context of acute PE. • Iterative reconstruction allows radiologists to approach the prospects of submilliSievert CT.
PURPOSE: To evaluate the impact of iterative reconstruction on the detectability of clots. METHODS AND MATERIALS: Fifty-three patients were enrolled in a study comparing reduced-dose and full-dose images, available from the same dual-source data set. From each acquisition, three series of images were generated: (1) full-dose images (from both tubes), reconstructed with filtered back projection (FBP) (group 1; standard of reference), (2) reduced-dose images (from tube A only; 60 % dose reduction) reconstructed with FBP (group 2) and iterative reconstruction (SAFIRE) (group 3). RESULTS: In group 1 (mean DLP: 264.6 mGy.cm), (1) PE was diagnosed in 8 patients (15 %) with 82 clots in the central (n = 5), segmental (n = 39) and subsegmental (n = 38) arteries and (2) mean level of noise was 30.56 ± 5.07. In group 2 (mean DLP: 105.8 mGy.cm), a significant increase in noise (44.56 ± 6.24; p < 0.0001) (1) hampered detection of PE in one patient and (2) altered detection of peripheral clots (12 false-negative and 2 false-positive results). In group 3, image noise was not significantly different from that in group 1 (p = 0.1525; effect size: 0.2683), with a similar detection of PE compared to group 1 (p = 1). CONCLUSION: Reconstruction of reduced-dose images (60 % dose reduction) with SAFIRE provided image quality and diagnostic value comparable to those of full-dose FBP images. KEY POINTS: • Iterative reconstruction does not alter the detection of endoluminal clots. • Iterative reconstruction allows dose reduction in the context of acute PE. • Iterative reconstruction allows radiologists to approach the prospects of submilliSievert CT.
Authors: Martine Remy-Jardin; Massimo Pistolesi; Lawrence R Goodman; Warren B Gefter; Alexander Gottschalk; John R Mayo; H Dirk Sostman Journal: Radiology Date: 2007-09-11 Impact factor: 11.105
Authors: Ali S Raja; Ivan K Ip; Luciano M Prevedello; Aaron D Sodickson; Cameron Farkas; Richard D Zane; Richard Hanson; Samuel Z Goldhaber; Ritu R Gill; Ramin Khorasani Journal: Radiology Date: 2011-12-20 Impact factor: 11.105
Authors: Mannudeep K Kalra; Mischa Woisetschläger; Nils Dahlström; Sarabjeet Singh; Subbarao Digumarthy; Synho Do; Homer Pien; Petter Quick; Bernhard Schmidt; Martin Sedlmair; Jo-Anne O Shepard; Anders Persson Journal: AJR Am J Roentgenol Date: 2013-08 Impact factor: 3.959
Authors: Sarabjeet Singh; Mannudeep K Kalra; Matthew D Gilman; Jiang Hsieh; Homer H Pien; Subba R Digumarthy; Jo-Anne O Shepard Journal: Radiology Date: 2011-03-08 Impact factor: 11.105
Authors: Doris Leithner; Tatjana Gruber-Rouh; Martin Beeres; Julian L Wichmann; Scherwin Mahmoudi; Simon S Martin; Lukas Lenga; Moritz H Albrecht; Christian Booz; Thomas J Vogl; Jan-Erik Scholtz Journal: Br J Radiol Date: 2018-06-05 Impact factor: 3.039
Authors: Paul D Stein; Fadi Matta; Patrick G Hughes; Zak N Hourmouzis; Nina P Hourmouzis; Robert E Schweiss; Jennifer A Bach; Viviane M Kazan; Edward J Kakish; Daniel C Keyes; Mary J Hughes Journal: Emerg Radiol Date: 2016-07-12
Authors: Rahul D Renapurkar; Andrew Primak; Joseph Azok; Jason Lempel; Yasmeen Tandon; Jennifer Bullen; Frank Dong; Wadih Karim; Ruffin Graham Journal: Eur Radiol Date: 2017-01-13 Impact factor: 5.315
Authors: Johannes Boos; Patric Kröpil; Rotem S Lanzman; Joel Aissa; Christoph Schleich; Philipp Heusch; Lino M Sawicki; Gerald Antoch; Christoph Thomas Journal: Br J Radiol Date: 2016-03-23 Impact factor: 3.039
Authors: Michael Scharf; Stephanie Brendel; Katja Melzer; Christian Hentschke; Matthias May; Michael Uder; Michael M Lell Journal: PLoS One Date: 2017-07-05 Impact factor: 3.240
Authors: Moritz Kaup; Tatjana Gruber-Rouh; Jan E Scholtz; Moritz H Albrecht; Andreas Bucher; Claudia Frellesen; Thomas J Vogl; Martin Beeres Journal: Acta Radiol Open Date: 2016-12-01